Pharmacoepidemiologist Denise Boudreau, PhD, joined Kaiser Permanente Washington Health Research Institute (KPWHRI) in 2003. Since then, she has played an integral role in investigations into the safety and effectiveness of pharmaceuticals. Highly regarded for her expertise in pharmacoepidemiologic methods, Dr. Boudreau has diverse experiences in the subject that span pharmacies, classrooms, and research institutions.
Dr. Boudreau uses “big data” to conduct research in real-world settings. She brings an in-depth working knowledge of Kaiser Permanente Washington pharmacy data and practices to her research, which ranges from cancer to opioid medication safety to treating opioid use disorder. She has been the Health Care Systems Research Network Steering Committee Representative for the U.S. Food and Drug Administration (FDA) Sentinel Initiative for the past 10 years and was extensively involved in developing both the data and methods for signal detection of adverse drug events. She is currently serving a 4-year term on the FDA Drug Safety and Risk Management Advisory Committee.
Dr. Boudreau has pioneered work in the field of medication safety relating to cancer risk and cancer outcomes, as well as medication management of comorbidities among cancer survivors. For the last 5 years, she has dedicated her research to helping find solutions the opioid epidemic and improve treatment of opioid use disorder in the United States. She is currently leading two large multisite studies on the risk of misuse, abuse, and addiction with long-term opioid therapy, and the risk of birth defects with opioid use during pregnancy. Dr. Boudreau is a co-investigator on a clinical trial to improve treatment of opioid use disorder. She is site principal investigator of a trial to test the effectiveness of pain self-management training with optional supported opioid taper among chronic high-dose opioid users.
Dr. Boudreau's research has been exhibited internationally at conferences such as the International Society for Pharmacoepidemiology, the International Society for Pharmacoeconomics and Outcomes Research, and the Congress of Epidemiology. Her professional memberships include the International Society for Pharmacoepidemiology.
Dr. Boudreau worked as a pharmacist before earning her master’s degree in pharmacy administration (1996) from the University of Rhode Island and PhD from the Pharmaceutical Outcomes and Research Policy Program (2002) at the University of Washington (UW). Dr. Boudreau is an affiliate professor in the UW School of Pharmacy and UW Department of Epidemiology where she teaches the graduate pharmacoepidemiology course and mentors students. She retains her pharmacy license in Washington state.
General drug safety research; pharmacoepidemiology; observational study research methods; active surveillance on the safety of pharmaceuticals; validation of pharmacy data sources; pharmacy practice research; benefits and risks of opioids; treatment of opioid use disorder; and clinical and biologic effect of commonly used medications on cancer risk and outcomes
Prevention and treatment
Fuller CC, Hua W, Leonard CE, Mosholder A, Carnahan R, Dutcher S, King K, Petrone AB, Rosofsky R, Shockro LA, Young J, Min JY, Binswanger I, Boudreau D, Griffin MR, Adgent MA, Kuntz J, McMahill-Walraven C, Pawloski PA, Ball R, Toh S. Developing a standardized and reusable method to link distributed health plan databases to the national death index: methods development study protocol. JMIR Res Protoc. 2020 Nov 2;9(11):e21811. doi: 10.2196/21811. PubMed
Kriplani A, Lavery JA, Mishra A, Korenstein D, Lipitz-Snyderman AN, Boudreau DM, Moryl N, Gillespie EF, Salz T. Trends in chronic opioid therapy among survivors of head and neck cancer. Head Neck. 2020 Sep 22. doi: 10.1002/hed.26478. Online ahead of print. PubMed
Her Q, Malenfant J, Zhang Z, Vilk Y, Young J, Tabano D, Hamilton J, Johnson R, Raebel M, Boudreau D, Toh S. Distributed regression analysis application in large distributed data networks: analysis of precision and operational performance. JMIR Med Inform. 2020;8(6):e15073. doi: 10.2196/15073. PubMed
Boudreau DM, Lapham G, Johnson EA, Bobb JF, Matthews AG, McCormack J, Liu D, Samet JH, Campbell CI, Rossom RC, Binswanger IA, Yarborough BJH, Arnsten JH, Cunningham CO, Glass JE, Murphy MT, Zare M, Hechter R, Ahmedani B, Braciszewski JM, Horigian VE, Szapocznik J, Samet JH, Saxon AJ, Schwartz RP, Bradley KA. Documented opioid use disorder and its treatment in primary care patients across six US health systems. J Subst Abuse Treat. 2020 Mar;112S:41-48. doi: 10.1016/j.jsat.2020.02.001. PubMed
Lapham G, Boudreau DM, Johnson EA, Bobb JF, Matthews AG, McCormack J, Liu D, Samet JH, Saxon AJ, Campbell CI, Glass JE, Rossom RC, Murphy MT, Binswanger IA, Yarborough BJH, Bradley KA. Prevalence and treatment of opioid use disorders among primary care patients in six health systems. Drug Alcohol Depend. 2020;207:107732. doi: 10.1016/j.drugalcdep.2019.107732. Epub 2019 Nov 15. PubMed
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