Denise Boudreau, PhD

Denise Boudreau

“The research I do informs patients and providers on the risks and benefits of medications.”

Denise Boudreau, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute

Biography

Pharmacoepidemiologist Denise Boudreau, PhD, joined Kaiser Permanente Washington Health Research Institute (KPWHRI) in 2003. Since then, she has played an integral role in investigations into the safety and effectiveness of pharmaceuticals. Highly regarded for her expertise in pharmacoepidemiologic methods, Dr. Boudreau has diverse experiences in the subject that span pharmacies, classrooms, and research institutions.

Dr. Boudreau uses “big data” to conduct research in real-world settings. She brings an in-depth working knowledge of Kaiser Permanente Washington pharmacy data and practices to her research, which ranges from cancer to opioid medication safety to treating opioid use disorder. She has been the Health Care Systems Research Network Steering Committee Representative for the U.S. Food and Drug Administration (FDA) Sentinel Initiative for the past 10 years and was extensively involved in developing both the data and methods for signal detection of adverse drug events. She is currently serving a 4-year term on the FDA Drug Safety and Risk Management Advisory Committee.

Dr. Boudreau has pioneered work in the field of medication safety relating to cancer risk and cancer outcomes, as well as medication management of comorbidities among cancer survivors. For the last 5 years, she has dedicated her research to helping find solutions the opioid epidemic and improve treatment of opioid use disorder in the United States. She is currently leading two large multisite studies on the risk of misuse, abuse, and addiction with long-term opioid therapy, and the risk of birth defects with opioid use during pregnancy. Dr. Boudreau is a co-investigator on a clinical trial to improve treatment of opioid use disorder. She is site principal investigator of a trial to test the effectiveness of pain self-management training with optional supported opioid taper among chronic high-dose opioid users.

Dr. Boudreau's research has been exhibited internationally at conferences such as the International Society for Pharmacoepidemiology, the International Society for Pharmacoeconomics and Outcomes Research, and the Congress of Epidemiology. Her professional memberships include the International Society for Pharmacoepidemiology.

Dr. Boudreau worked as a pharmacist before earning her master’s degree in pharmacy administration (1996) from the University of Rhode Island and PhD from the Pharmaceutical Outcomes and Research Policy Program (2002) at the University of Washington (UW). Dr. Boudreau is an affiliate professor in the UW School of Pharmacy and UW Department of Epidemiology where she teaches the graduate pharmacoepidemiology course and mentors students. She retains her pharmacy license in Washington state.

Research interests and experience

  • Medication Use & Patient Safety

    General drug safety research; pharmacoepidemiology; observational study research methods; active surveillance on the safety of pharmaceuticals; validation of pharmacy data sources; pharmacy practice research; benefits and risks of opioids; treatment of opioid use disorder; and clinical and biologic effect of commonly used medications on cancer risk and outcomes

  • Addictions 

    Prevention and treatment

Recent publications

Li CI, Malone KE, Weiss NS, Boudreau DM, Cushing-Haugen KL, Daling JR. Relation between use of antihypertensive medications and risk of breast carcinoma among women ages 65-79 years. Cancer. 2003;98(7):1504-13. PubMed

Boudreau DM, Leveille SG, Gray SL, Black DJ, Guralnik JM, Ferrucci L, LaCroix AZ. Risks for frequent antimicrobial-treated infections in postmenopausal women. Aging Clin Exp Res. 2003;15(1):12-8. PubMed

Boudreau DM, Capoccia KL, Sullivan SD, Blough DK, Ellsworth A, Clark DL, Katon WJ, Walker EA, Stevens NG. Collaborative care model to improve outcomes in major depression. Ann Pharmacother. 2002; 36:585-591. PubMed

Chaiyakunapruk N, Boudreau DM, Ramsey S. Pharmaco-economic impact of HMG-CoA reductase inhibitors in type 2 diabetes.Pharmaco-economic impact of HMG-CoA reductase inhibitors in type 2 diabetes. J Cardiovasc Risk. 2001;8(3):127-132. PubMed

Mosher BA, Cuddigan J, Thomas DR, Boudreau DM. Outcomes of 4 methods of debridement using a decision analysis methodology. Advances in Wound Care. 1999;12(2):81-88. PubMed

 

chronic pain management

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The opioid crisis: How our research is seeking solutions

Tom Petty’s accidental death from opioids shows we need to find safer alternatives for chronic pain. See how KPWHRI research helps to do just that.

aging & geriatrics

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Do drugs cause falls for adults with dementia?

Researchers find a relationship between prescribed central nervous system-active medications and increased risk of falling among older people with dementia.

opioids

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Patient-doctor trust withstands opioid risk reduction

Risk-reduction initiative for chronic opioid therapy sustains patient-doctor trust, Dr. Karen Sherman finds.

medication safety

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Using phentermine for weight loss longer term found to be safe, effective

Dr. David Arterburn discusses reassuring news from his PCORnet study of the most widely used anti-obesity drug in the United States.