Katherine M. Newton, PhD


“The work I do helps women make decisions about managing menopause symptoms.”

Katherine M. Newton, PhD

Senior Investigator (Emeritus), Kaiser Permanente Washington Health Research Institute


Katherine Newton, PhD, is a chronic disease epidemiologist who is passionate about finding ways to help women stay healthy during midlife. Known for her research on menopause, Dr. Newton is a national leader in the search for nonhormonal treatments for menopausal symptoms.

After a 20-year career as a cardiovascular nurse specialist, Dr. Newton pursued her PhD in epidemiology and shifted her focus to epidemiologic research, joining Kaiser Permanente Washington Health Research Institute (KPWHRI) as a postdoctoral fellow in 1995. Dr. Newton focuses on health concerns for women reaching midlife, especially menopause. Dr. Newton’s current goal is to help women transition through menopause in the healthiest way possible. She is especially interested in investigating ways to relieve menopause symptoms without using hormone replacement therapy.

Dr. Newton’s 2006 randomized trial of alternative therapies for menopause received widespread interest, leading to several invited talks around the world. Study analyses continue to yield compelling findings, including a 2007 publication linking low libido in menopause to trouble sleeping. She is currently participating in a multisite network of investigators, MsFLASH Finding Lasting Answers for Symptoms and Health. This group has conducted 6 randomized trials testing the efficacy of yoga, exercise, omega-3 fatty acids, escitalopram, and low-dose estrogen for menopause symptoms, and a study of telephone-based cognitive behavioral therapy for sleep among women with sleep problems related to menopause.

Dr. Newton is a member of the North American Menopause Society. She held two faculty appointments at the University of Washington: affiliate associate professor in epidemiology and affiliate associate professor in biobehavioral nursing and health systems.

Research interests and experience

Recent publications

Newton KM, Peissig PL, Kho AN, Bielinski SJ, Berg RL, Choudhary V, Basford M, Chute CG, Kullo IJ, Li R, Pacheco JA, Rasmussen LV, Spangler L, Denny JC. Validation of electronic medical record-based phenotyping algorithms: results and lessons learned from the eMERGE Network. J Am Med Inform Assoc. 2013 Jun;20(e1):e147-54. doi: 10.1136/amiajnl-2012-000896. Epub 2013 Mar 26. PubMed

Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, Crane PK, Newton K, Carrell DS, Gallego CJ, Nalls MA, Li R, Mirel DB, Crenshaw A, Couper DJ, Tanaka T, van Rooij FJA, Chen M-H, Smith AV, Zakai NA, Yango Q, Garcia M, Liu Y, Lumley T, Folsom AR, Reiner AP, Felix JF, Dehghan A, Wilson Jg, Bis JC, Fox CS, Glazer NL, Cupples LA, Coresh J, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Witteman JCM, Psaty BM, Ferrucci L, Harris TB, O’Donnell CJ, Ganesh SK, CHARGE Hematology Working Group, Larson EB, Carlson CS, Jarvik GP, and the Electronic Medical Records and Genomics (eMERGE) Network. Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet. 2013 May 15;22(10):2119-27. doi: 10.1093/hmg/ddt010. Epub 2013 Jan 12. PubMed

Sternfeld B, LaCroix A, Caan BJ, Dunn AL, Newton KM, Reed SD, Guthrie KA, Booth-Laforce C, Sherman KJ, Cohen L, Freeman MP, Carpenter JS, Hunt JR, Roberts M, Ensrud KE. Design and methods of a multi-site, multi-behavioral treatment trial for menopausal symptoms: The MsFLASH experience. Contemp Clin Trials. 2013 May;35(1):25-34. doi: 10.1016/j.cct.2013.02.009. Epub 2013 Feb 24. PubMed

Reed SD, Lampe JW, Qu C, Gundersen G, Fuller S, Copeland WK, Newton KM. Self-reported menopausal symptoms in a racially diverse population and soy food consumption. Maturitas. 2013 Jun;75(2):152-8. doi:10.1016/j.maturitas.2013.03.003. Epub 2013 Apr 3. PubMed

Schick UM, McDavid A, Crane PK, Weston N, Ehrlich K, Newton KM, Wallace R, Bookman E, Harrison T, Aragaki A, Wang SS, Reiner AP, Jackson RD, Peters U, Larson EB, Jarvik GP, Carlson CS. Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer. PLoS One 8(3):e59823. doi:10.1371/journal.pone.0059823. PubMed

Thacker EL, McKnight B, Psaty BM, Longstreth WT Jr, Dublin S, Jensen PN, Newton KM, Smith NL, Siscovick DS, Heckbert SR. Association of body mass index, diabetes, hypertension, and blood pressure levels with risk of permanent atrial fibrillation. J Gen Intern Med. 2013 Feb;28(2):247-53. doi: 10.1007/s11606-012-2220-4. Epub 2012 Sep 13. PubMed

McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA, Rottscheit C, Peissig P, Stefanski E, McCarty CA, Zuvich RL, Ritchie MD, Haines JL, Denny JC, Schellenberg GD, de Andrade M, Kullo I, Li R, Miirel D, Crenshaw A, Larson E, Carlson C. Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records. PLoS One. 2013 Jun 10;8(6):e63481. doi: 10.1371/journal.pone.0063481. Print 2013. PubMed

LaCroix AZ, Freeman EW, Larson J, Carpenter JS, Joffe H, Reed SD, Newton KM, Seguin RA, Sternfeld B, Cohen L, Ensrud KE. Effects of escitalopram on menopause-specific quality of life and pain in healthy menopausal women with hot flashes: A randomized controlled trial. Maturitas. 2012 Dec;73(4):361-8. doi: 10.1016/j.maturitas.2012.09.006. Epub 2012 Sep 30. PubMed

Newton KM, Larson EB. Learning health care systems: leading through research: the 18th annual HMO research network conference, april 29-may 2, 2012, seattle, washington. Clin Med Res. 2012;10(3):140-2. PubMed

Fuller S, Ludman E, Mohelnitzky A, Gundersen G, Wellman R, Reid R, Newton K. CC2-01: A telephone-based diabetes prevention program and social support for weight loss: the Call-2-Health study. Clin Med Res. 2012;10(3):143. PubMed


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