Denise Boudreau, PhD

Denise Boudreau

“The research I do informs patients and providers on the risks and benefits of medications.”

Denise Boudreau, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute

Biography

Pharmacoepidemiologist Denise Boudreau, PhD, joined Kaiser Permanente Washington Health Research Institute (KPWHRI) in 2003. Since then, she has played an integral role in investigations into the safety and effectiveness of pharmaceuticals. Highly regarded for her expertise in pharmacoepidemiologic methods, Dr. Boudreau has diverse experiences in the subject that span pharmacies, classrooms, and research institutions.

Dr. Boudreau uses “big data” to conduct research in real-world settings. She brings an in-depth working knowledge of Kaiser Permanente Washington pharmacy data and practices to her research, which ranges from cancer to opioid medication safety to treating opioid use disorder. She has been the Health Care Systems Research Network Steering Committee Representative for the U.S. Food and Drug Administration (FDA) Sentinel Initiative for the past 10 years and was extensively involved in developing both the data and methods for signal detection of adverse drug events. She is currently serving a 4-year term on the FDA Drug Safety and Risk Management Advisory Committee.

Dr. Boudreau has pioneered work in the field of medication safety relating to cancer risk and cancer outcomes, as well as medication management of comorbidities among cancer survivors. For the last 5 years, she has dedicated her research to helping find solutions the opioid epidemic and improve treatment of opioid use disorder in the United States. She is currently leading two large multisite studies on the risk of misuse, abuse, and addiction with long-term opioid therapy, and the risk of birth defects with opioid use during pregnancy. Dr. Boudreau is a co-investigator on a clinical trial to improve treatment of opioid use disorder. She is site principal investigator of a trial to test the effectiveness of pain self-management training with optional supported opioid taper among chronic high-dose opioid users.

Dr. Boudreau's research has been exhibited internationally at conferences such as the International Society for Pharmacoepidemiology, the International Society for Pharmacoeconomics and Outcomes Research, and the Congress of Epidemiology. Her professional memberships include the International Society for Pharmacoepidemiology.

Dr. Boudreau worked as a pharmacist before earning her master’s degree in pharmacy administration (1996) from the University of Rhode Island and PhD from the Pharmaceutical Outcomes and Research Policy Program (2002) at the University of Washington (UW). Dr. Boudreau is an affiliate professor in the UW School of Pharmacy and UW Department of Epidemiology where she teaches the graduate pharmacoepidemiology course and mentors students. She retains her pharmacy license in Washington state.

Research interests and experience

  • Medication Use & Patient Safety

    General drug safety research; pharmacoepidemiology; observational study research methods; active surveillance on the safety of pharmaceuticals; validation of pharmacy data sources; pharmacy practice research; benefits and risks of opioids; treatment of opioid use disorder; and clinical and biologic effect of commonly used medications on cancer risk and outcomes

  • Addictions 

    Prevention and treatment

Recent publications

Calip GS, Elmore JG, Boudreau DM. Characteristics associated with nonadherence to medications for hypertension, diabetes, and dyslipidemia among breast cancer survivors. Breast Cancer Res Treat. 2017 Jan;161(1):161-172. doi: 10.1007/s10549-016-4043-1. Epub 2016 Nov 8. PubMed

Reynolds K, Go AS, Leong TK, Boudreau DM, Cassidy-Bushrow AE, Fortmann SP, Goldberg RJ, Gurwitz JH, Magid DJ, Margolis KL, McNeal CJ, Newton KM, Novotny R, Quesenberry CP Jr, Rosamond WD, Smith DH, VanWormer JJ, Vupputuri S, Waring SC, Williams MS, Sidney S. Trends in incidence of hospitalized acute myocardial infarction in the Cardiovascular Research Network (CVRN). Am J Med. 2016 Oct 14. pii: S0002-9343(16)31020-8. doi: 10.1016/j.amjmed.2016.09.014. [Epub ahead of print]. PubMed

Hart R, Veenstra DL, Boudreau DM, Roth JA. The impact of body mass index and genetics on warfarin major bleeding outcomes in a community setting. Am J Med. 2016 Sep 1. pii: S0002-9343(16)30860-9. doi: 10.1016/j.amjmed.2016.08.017 [Epub ahead of print]. PubMed

Drieling RL, LaCroix AZ, Beresford SA, Boudreau DM, Kooperberg C, Chlebowski RT, Gass M, Crandall CJ, Womack CR, Heckbert SR. Long-term oral bisphosphonate use in relation to fracture risk in postmenopausal women with breast cancer: findings from the Women's Health Initiative. Menopause. 2016 Nov;23(11):1168-1175. PubMed

Drieling RL, LaCroix AZ, Beresford SA, Boudreau DM, Kooperberg C, Heckbert SR. Validity of self-reported medication use compared with pharmacy records in a cohort of older women: findings from the Women's Health Initiative. Am J Epidemiol. 2016 Jul 7. pii: kwv446. [Epub ahead of print]. PubMed

 

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