Diana S.M. Buist, PhD, MPH

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“My research goal is to gather solid evidence and to use it to improve patient care by increasing benefits and decreasing harms.”

Diana S.M. Buist, PhD, MPH

Senior Investigator and Director of Research and Strategic Partnerships, Kaiser Permanente Washington Health Research Institute

Twitter: @dianabuist

Biography

Diana Buist, PhD, MPH, is an epidemiologist and health services researcher with extensive experience conducting comparative effectiveness research. Her work focuses on reducing harms and increasing benefits for patients in the area of cancer screening and outcomes spanning across patient, provider, and system factors.

Dr. Buist has an extensive record of practical research that has led to many efforts to improve care, including the development and refinement of national breast cancer screening guidelines and their implementation within Kaiser Permanente Washington. She has been conducting research within Kaiser Permanente Washington for more than 20 years and is a strong believer in patient-centered care and the important role patients play in improving the value and quality of health care. Dr. Buist is involved in several studies aimed at providing high-value health care that provides patients and their providers with information on the expected benefits and harms of cancer screening and treatment strategies.

Dr. Buist also has a long history collaborating with external researchers, including helping lead two large national research consortia focused on improving cancer screening and outcomes: the National Cancer Institute’s Breast Cancer Surveillance Consortium and the Cancer Research Network of the Health Care Systems Research Network. Her extensive experience working with diverse data from these consortia in longitudinal studies and randomized trials in clinical systems puts Dr. Buist in a unique position to examine screening, care, and outcomes in health systems across the country.

As Kaiser Permanente Washington Health Research Institute (KPWHRI) Director of Research and Strategic Partnerships, Dr. Buist works with other Kaiser Permanente regions, our local academic partners, and other external collaborators to build enduring strategic partnerships to enhance KPWHRI’s mission, align with KPWHRI faculty research priorities, and capitalize on our unique strengths in ways that are consistent with our mission.

Dr. Buist contributes to a variety of other projects at KPWHRI, including:

  • conducting a pragmatic clinical trial of home testing for human papilloma virus, or HPV, among women overdue for cervical cancer screening
  • optimizing long-term outcomes among women with a personal history of breast cancer through studying second breast events and second cancers associated with initial breast cancer, and investigating radiation therapy, breast density, tumor biology, and surveillance strategies for these women
  • identifying screening strategies that detect breast cancer early, minimize harms, and reach diverse communities
  • understanding the shared decision-making process for lung cancer screening from the patient and provider perspectives to help inform individuals about the harms and benefits of undergoing screening
  • investigating how artificial intelligence can be used in cancer imaging for risk prediction and/or early detection
  • evaluating the harms and benefits of different work-up intensities for incidentally detected lung nodules
  • training individuals in how to conduct learning health system research.

Dr. Buist is also an affiliate professor in the Departments of Epidemiology and Health Services at the University of Washington School of Public Health and an affiliate member at Fred Hutchinson Cancer Research Center. She enjoys sharing her expertise by mentoring junior faculty and PhD and MPH candidates and teaching courses.

RESEARCH INTERESTS AND EXPERIENCE

  • Cancer

    Cancer screening and prevention; outreach and primary care prevention; comparative effectiveness; cost transparency; surveillance; secondary prevention; breast cancer treatment; breast cancer screening; outcomes following cancer diagnosis; cancer survivorship; provider variability in care

  • Preventive Medicine

    Cancer prevention and control; quality of care; preventive care; high-value care; consumer engagement in preventive medicine; systematic reviews

  • Women's Health

    Cancer prevention and control

  • Health Services & Economics

     

 

Recent publications

Sprague BL, Trentham-Dietz A, Hedman CJ, Wang J, Hemming JD, Hampton JM, Buist DS, Bowles EJ, Sisney GS, Burnside ES. Circulating serum xenoestrogens and mammographic breast density. Breast Cancer Res. 2014 Jan;174(1):25-31. doi: 10.1001/jamainternmed.2013.11074. Erratum in: JAMA Intern Med. 2014 Sep;174(9):1523. Epub 2013 Sep 30. PubMed

Onega T, Weiss J, Kerlikowske K, Wernli K, Buist DS, Henderson LM, Goodrich M, Alford-Teaster J, Virnig B, Tosteson AN, DeMartini W, Hubbard R. The influence of race/ethnicity and place of service on breast reconstruction for Medicare beneficiaries with mastectomy. Springerplus. 2014 Aug 8;3:416. doi: 10.1186/2193-1801-3-416. eCollection 2014. PubMed

Stout NK, Nekhlyudov L, Li L, Malin ES, Ross-Deganan D, Buist DS, Rosenber MA, Alfisher M, Fletcher SW. Rapid increase in breast magnetic resonance imaging use: trends from 2000-2011. JAMA Intern Med. 2014 Jan;174(1):114-21. doi: 10.1001/jamainternmed.2013.11958. Epub 2013 Nov 18. PubMed

Wernli KJ, O’Meara E, Kerlikowske K, Miglioretti D, Muller CY, Onega T, Sprague B, Henderson L, Buist DS. Investigation of mammographic breast density as a risk factor for ovarian cancer. J Nat Cancer Inst. 2014 Jan 1;106(1):djt341. doi: 10.1093/jnci/djt341. Epub 2013 Dec 5. PubMed

Buist DS, Knight Ross N, Reid RJ, Grossman DC. Electronic health risk assessment adoption in an integrated healthcare system. Am J Manag Care. 2014 Jan;20(1):62-9.

Carney PA, Geller BM, Bogart A, Sickles EA, Smith RA, Buist DS, Kerlikowske K, Onega TL, Miglioretti DL, Rosenberg R, Yankaskas BC. Feasibility and acceptability of conducting a randomized clinical trial designed to improve interpretation of screening mammography. Acad Radiol. 2013 Nov;20(11):1389-98. doi: 10.1016/j.acra.2013.08.017. PubMed

Buist DS, Bosco JL, Silliman RA, Gold HT, Field T, Yood MU, Quinn VP, Prout M, Lash TL. Long-term surveillance mammography and mortality in older women with a history of early stage invasive breast cancer. Breast Cancer Res Treat. 2013 Nov;142(1):153-63. doi: 10.1007/s10549-013-2720-x. Epub 2013 Oct 11. PubMed

Schairer C, Li Y, Frawley P, Graubard BI, Wellman RD, Buist DS, Kerlikowske K, Onega TL, Anderson WF, Miglioretti DL. Risk factors for inflammatory breast cancer and other invasive breast cancers. J Natl Cancer Inst. 2013 Sep 18;105(18):1373-84. PubMed

Wirtz HS, Buist DS, Gralow JR, Barlow WE, Gray SL, Chubak J, Yu O, Bowles EJ, Fujii M, Boudreau DM. Frequent antibiotic use and second breast cancer events. Cancer Epidemiol Biomarkers Prev. 2013 Sep;22(9):1588-99. doi:10.1158/1055-9965.EPI-13-0454. Epub 2013 Jul 5. PubMed

Chubak J, Yu O, Buist DS, Wirtz HS, Boudreau DM. Time scale in follow-up studies: considering disease prognosis. Epidemiology. 2013;24(4):628-9. doi: 10.1097/EDE.0b013e3182961708. PubMed

 

preventive care

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Exploring at-home cervical cancer screening

Kaiser Permanente is at the forefront of research looking at using home tests for HPV, a leading cause of cervical cancer.

Cancer screening

Breast density scans

Breast density is a risk factor for older women, too

Findings in JAMA Network Open could help guide decision-making about breast cancer screening for women 75 and older.

CATALyST

CATALyST Scholars

2 new scholars join learning health systems program

Scholars will study in-home oxygen use for COPD and the use of patient portals for adolescent sexual and reproductive health.

Cancer screening

An older woman stands in front of a mammography machine, preparing for her scan

Catching breast cancers when mammograms are limited

New study calculates risk-based approach to detect the most cancers with the fewest exams.

Breast Cancer Surveillance

Kaiser Permanente Washington Breast Cancer Surveillance Registry

Kaiser Permanente Washington has been part of the national Breast Cancer Surveillance Consortium since 1994. Learn about the Kaiser Permanente Washington Breast Cancer Surveillance Registry here.

Healthy Findings Blog

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Cancer screening in the time of COVID-19

Dr. Diana Buist reflects on the challenges of providing screening during a pandemic — and finds reason for optimism.

KPWHRI In the Media

KPWHRI’s Diana Buist, PhD, quoted on one alternative to screening visits

At-home cancer screening could thrive after the pandemic

Reuters Health, published by Medscape, Nov. 24, 2020