Eric B. Larson, MD, MPH, is a senior investigator at Kaiser Permanente Washington Health Research Institute. He served as the institute's executive director from 2002 through 2018, as well as vice president for research and health care innovation at Kaiser Permanente Washington from 2017 to 2018.
A general internist, Dr. Larson is a national leader in geriatrics, health services, and clinical research and has been an elected member of the National Academy of Medicine since 2007. He pursues an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, learning health systems, and quality improvement. His research on aging includes a longstanding collaboration between Kaiser Permanente Washington and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. Among ACT’s many groundbreaking findings:
With colleagues from Duke and Harvard, Dr. Larson established and now helps lead the National Institutes of Health (NIH) Common Fund’s Health Care Systems Research Collaboratory. The Collaboratory sponsors pragmatic clinical trials and aims to improve the way clinical trials are conducted so that patients and care providers have access to the best available clinical evidence for decision-making. Dr. Larson is also the principal investigator for the Electronic Medical Records and Genomics (eMERGE) project at KPWHRI and the UW. The goal of eMERGE research is to better understand the genomic basis of disease to tailor medical care to individual patients based on their genomic differences.
Dr. Larson has written or co-authored more than a dozen books, including 2017’s Enlightened Aging: Building Resilience for Long, Active Life, which draws from his decades of work as a physician and the leader of the ACT study. He has also published more than 500 peer-reviewed scientific papers.
Until 2019, Dr. Larson maintained a small but longstanding internal medicine practice. He served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a master of the American College of Physicians (ACP) and served on its Board of Regents for nearly a decade, including one term as chair. He was a commissioner on The Joint Commission from 1999 to 2010.
Chronic illness; cost effectiveness analysis; performance measurement and incentives
Pharmacogenetics; drug safety
Self-management; patient/provider relationships
Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, van Iperen E, Hovingh K, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Lill CM, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott RA, Luan J, Bobak M, Malyutina S, Pajak A, Kubinova R, Tamosiunas A, Pikhart H, Grarup N, Pedersen O, Hansen T, Linneberg A, Jess T, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Lester KH, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, Scott R, Schofield P, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H; Lifelines Cohort authors, Christen T, Mook-Kanamori DO; ICBP Consortium, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Meade T, Christophersen IE, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Roussel R, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Hopewell JC, Seshadri S; METASTROKE Consortium of the ISGC, Dale C, Costa RPE, Ridker PM, Chasman DI, Reiner AP, Ritchie MD, Lange LA, Cornish AJ, Dobbins SE, Hemminki K, Kinnersley B, Sanson M, Labreche K, Simon M, Bondy M, Law P, Speedy H, Allan J, Li N, Went M, Weinhold N, Morgan G, Sonneveld P, Nilsson B, Goldschmidt H, Sud A, Engert A, Hansson M, Hemingway H, Asselbergs FW, Patel RS, Keating BJ, Sattar N, Houlston R, Casas JP, Hingorani AD. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. BMC Cardiovasc Disord. 2019;19(1):240. doi: 10.1186/s12872-019-1187-z. PubMed
Barnes DE, Zhou J, Walker RL, Larson EB, Lee SJ, Boscardin WJ, Marcum ZA, Dublin S. Development and validation of eRADAR: a tool using EHR data to detect unrecognized dementia. J Am Geriatr Soc. 2019 Oct 14. doi: 10.1111/jgs.16182. [Epub ahead of print]. PubMed
Robinson JR, Carroll RJ, Bastarache L, Chen Q, Mou Z, Wei WQ, Connolly JJ, Mentch F, Sleiman P, Crane PK, Hebbring SJ, Stanaway IB, Crosslin DR, Gordon AS, Rosenthal EA, Carrell D, Hayes MG, Wei W, Petukhova L, Namjou B, Zhang G, Safarova MS, Walton NA, Still C, Bottinger EP, Loos RJF, Murphy SN, Jackson GP, Kullo IJ, Hakonarson H, Jarvik GP, Larson EB, Weng C, Roden DM, Denny JC. Association of genetic risk of obesity with postoperative complications using Mendelian randomization. World J Surg. 2019 Oct 11. doi: 10.1007/s00268-019-05202-9. [Epub ahead of print]. PubMed
Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M; Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative, Bennett DA, Schneider JA, Jefferson AL, Hohman TJ. Sex differences in the genetic predictors of Alzheimer's pathology. Brain. 2019;142(9):2581-2589. doi: 10.1093/brain/awz206. PubMed
Gordon AS, Rosenthal EA, Carrell DS, Amendola LM, Dorschner MO, Scrol A, Stanaway IB, DeVange S, Ralston JD, Zouk H, Rehm HL, Larson E, Crosslin DR, Leppig KA, Jarvik GP. Rates of actionable genetic findings in individuals with colorectal cancer or polyps ascertained from a community medical setting. Am J Hum Genet. 2019 Aug 8. pii: S0002-9297(19)30275-7. doi: 10.1016/j.ajhg.2019.07.012. [Epub ahead of print]. PubMed
Ehlenbach WJ, Sonnen JA, Montine TJ, Larson EB. Association between sepsis and microvascular brain injury. Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003924. [Epub ahead of print]. PubMed
Ehlenbach WJ, Sonnen JA, Montine TJ, Larson EB. Association between sepsis and mocrovascular brain injury. Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003924. [Epub ahead of print]. PubMed
Fishman P, Coe NB, White L, Crane PK, Park S, Ingraham B, Larson EB. Cost of dementia in Medicare managed care: a systematic literature review. Am J Manag Care. 2019;25(8):e247-e253. PubMed
Namjou B, Lingren T, Huang Y, Parameswaran S, Cobb BL, Stanaway IB, Connolly JJ, Mentch FD, Benoit B, Niu X, Wei WQ, Carroll RJ, Pacheco JA, Harley ITW, Divanovic S, Carrell DS, Larson EB, Carey DJ, Verma S, Ritchie MD, Gharavi AG, Murphy S, Williams MS, Crosslin DR, Jarvik GP, Kullo IJ, Hakonarson H, Li R; eMERGE Network, Xanthakos SA, Harley JB. GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. BMC Med. 2019 Jul 17;17(1):135. doi: 10.1186/s12916-019-1364-z. PubMed
Bauman J, Gibbons LE, Moore M, Mukherjee S, McCurry SM, McCormick W, Bowen JD, Trittschuh E, Glymour M, Mez J, Saykin AJ, Dams-O'Conner K, Bennett DA, Larson EB, Crane PK. Associations between depression, traumatic brain injury, and cognitively-defined late-onset Alzheimer's disease subgroups. J Alzheimers Dis. 2019 Jun 24. pii: JAD181212. doi: 10.3233/JAD-181212. [Epub ahead of print]. PubMed
Dr. Eric Larson reflects on KPWHRI’s incoming leader, the institute’s accomplishments over time, and its sustaining values.
Pain is a universal experience for all living creatures. And nearly every person will experience enough chronic pain to seek medical care at some time in their life—so how do we change how we think about and experience it?
Dr. Eric B. Larson explores how prevention, testing, and treatment must be tailored to meet the needs of patients in late life.
3rd Act magazine, Spring 2019
Produced by Alzheimer's Disease International (YouTube, 4:39)
Reuters Health, May 30, 2019