Eric B. Larson, MD, MPH

Larson_Eric__205x293.jpg

“As the public-interest research arm of Kaiser Permanente Washington's learning health care system and a member of major research consortia, KPWHRI is honored to contribute to local and national health care improvements.”

Eric B. Larson, MD, MPH

Kaiser Permanente Washington Health Research Institute Senior Investigator
Former executive director of Kaiser Permanente Washington Health Research Institute and former vice president for research and health care innovation of Kaiser Permanente Washington

Biography

Eric B. Larson, MD, MPH, is a senior investigator at Kaiser Permanente Washington Health Research Institute. He served as the institute's executive director from 2002 through 2018, as well as vice president for research and health care innovation at Kaiser Permanente Washington from 2017 to 2018.

A general internist, Dr. Larson is a national leader in geriatrics, health services, and clinical research and has been an elected member of the National Academy of Medicine since 2007. He pursues an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, learning health systems, and quality improvement. His research on aging includes a longstanding collaboration between Kaiser Permanente Washington and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. Among ACT’s many groundbreaking findings:

  • Regular exercise is linked to reduced risk of dementia, Alzheimer's disease, and declines in how well people think.
  • Use of larger amounts of common medications that have strong anticholinergic side effects is linked to higher risks for developing dementia, including Alzheimer’s disease.
  • Risk for dementia in old age can be linked to early life factors, such as socioeconomic status, education, and midlife vascular risk factors.
  • Risk for dementia is also tied to high blood sugar levels, even without diabetes.

With colleagues from Duke and  Harvard, Dr. Larson established and now helps lead the National Institutes of Health (NIH) Common Fund’s Health Care Systems Research Collaboratory. The Collaboratory sponsors pragmatic clinical trials and aims to improve the way clinical trials are conducted so that patients and care providers have access to the best available clinical evidence for decision-making. Dr. Larson is also the principal investigator for the Electronic Medical Records and Genomics (eMERGE) project at KPWHRI and the UW. The goal of eMERGE research is to better understand the genomic basis of disease to tailor medical care to individual patients based on their genomic differences.

Dr. Larson has written or co-authored more than a dozen books, including 2017’s Enlightened Aging: Building Resilience for Long, Active Life, which draws from his decades of work as a physician and the leader of the ACT study. He has also published more than 500 peer-reviewed scientific papers.

Until 2019, Dr. Larson maintained a small but longstanding internal medicine practice. He served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a master of the American College of Physicians (ACP) and served on its Board of Regents for nearly a decade, including one term as chair. He was a commissioner on The Joint Commission from 1999 to 2010. 

Research interests and experience

 

Recent publications

Kumar RG, Jayasinghe N, Walker RL, Gibbons LE, Power MC, Larson EB, Crane PK, Connor KD. Association of remote traumatic brain injury and military employment with late-life trajectories of depressive symptom severity. J Affect Disord. 2020 Dec 5;281:376-383. doi: 10.1016/j.jad.2020.12.003. [Epub ahead of print]. PubMed

Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C; Alzheimer’s Disease Genetics Consortium (ADGC), Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. Novel Alzheimer disease risk loci and pathways in African American individuals using the African genome resources panel: a meta-analysis. JAMA Neurol. 2020 Oct 19. doi: 10.1001/jamaneurol.2020.3536. [Epub ahead of print]. PubMed

Klarin D, Verma SS, Judy R, Dikilitas O, Wolford BN, Paranjpe I, Levin MG, Pan C, Tcheandjieu C, Spin JM, Lynch J, Assimes TL, Nyrønning LÅ, Mattsson E, Edwards TL, Denny J, Larson E, Lee MTM, Carrell D, Zhang Y, Jarvik GP, Gharavi AG, Harley J, Mentch F, Pacheco JA, Hakonarson H, Skogholt AH, Thomas L, Gabrielsen ME, Hveem K, Nielsen JB, Zhou W, Fritsche L, Huang J, Natarajan P, Sun YV, DuVall SL, Rader DJ, Cho K, Chang KM, Wilson PWF, O'Donnell CJ, Kathiresan S, Scali ST, Berceli SA, Willer C, Jones GT, Bown MJ, Nadkarni G, Kullo IJ, Ritchie M, Damrauer SM, Tsao PS. Genetic architecture of abdominal aortic aneurysm in the Million Veteran program. Circulation. 2020 Sep 28. doi: 10.1161/CIRCULATIONAHA.120.047544. [Epub ahead of print]. PubMed

Palmer MR, Kim DS, Crosslin DR, Stanaway IB, Rosenthal EA, Carrell DS, Cronkite DJ, Gordon A, Du X, Li YK, Williams MS, Weng C, Feng Q, Li R, Pendergrass SA, Hakonarson H, Fasel D, Sohn S, Sleiman P, Handelman SK, Speliotes E, Kullo IJ, Larson EB, Ja+++. Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network. Genet Epidemiol. 2021 Feb;45(1):4-15. doi: 10.1002/gepi.22360. Epub 2020 Sep 22. PubMed

Park S, Larson EB, Fishman P, White L, Coe NB. Differences in health care utilization, process of diabetes care, care satisfaction, and health status in patients with diabetes in Medicare Advantage versus traditional Medicare. Med Care. 2020 Nov;58(11):1004-1012. doi: 10.1097/MLR.0000000000001390. PubMed

Rosenberg D, Walker R, Greenwood-Hickman MA, Bellettiere J, Xiang Y, Richmire K, Higgins M, Wing D, Larson EB, Crane PK, LaCroix AZ. Device-assessed physical activity and sedentary behavior in a community-based cohort of older adults. BMC Public Health. 2020 Aug 18;20(1):1256. doi: 10.1186/s12889-020-09330-z. PubMed

Kawai VK, Shi M, Feng Q, Chung CP, Liu G, Cox NJ, Jarvik GP, Lee MTM, Hebbring SJ, Harley JB, Kaufman KM, Namjou B, Larson E, Gordon AS, Roden DM, Stein CM, Mosley JD; eMERGE investigators. Pleiotropy in the genetic predisposition to rheumatoid arthritis - a phenome-wide association study and inverse-variance weighted meta-analysis. Arthritis Rheumatol. 2020 Sep;72(9):1483-1492. doi: 10.1002/art.41291. Epub 2020 Aug 6. PubMed

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413-446. doi: 10.1016/S0140-6736(20)30367-6. Epub 2020 Jul 30. PubMed

Grossman DC, Larson EB, Sox HC. Integrating personalized medicine with population health management: the path forward. JAMA. 2020 Jul 30. doi: 10.1001/jama.2020.1406. [Epub ahead of print]. PubMed

Thomas M, Sakoda LC, Hoffmeister M, Rosenthal EA, Lee JK, van Duijnhoven FJB, Platz EA, Wu AH, Dampier CH, de la Chapelle A, Wolk A, Joshi AD, Burnett-Hartman A, Gsur A, Lindblom A, Castells A, Win AK, Namjou B, Van Guelpen B, Tangen CM, He Q, Li CI, Schafmayer C, Joshu CE, Ulrich CM, Bishop DT, Buchanan DD, Schaid D, Drew DA, Muller DC, Duggan D, Crosslin DR, Albanes D, Giovannucci EL, Larson E, Qu F, Mentch F, Giles GG, Hakonarson H, Hampel H, Stanaway IB, Figueiredo JC, Huyghe JR, Minnier J, Chang-Claude J, Hampe J, Harley JB, Visvanathan K, Curtis KR, Offit K, Li L, Le Marchand L, Vodickova L, Gunter MJ, Jenkins MA, Slattery ML, Lemire M, Woods MO, Song M, Murphy N, Lindor NM, Dikilitas O, Pharoah PDP, Campbell PT, Newcomb PA, Milne RL, MacInnis RJ, Castellví-Bel S, Ogino S, Berndt SI, Bézieau S, Thibodeau SN, Gallinger SJ, Zaidi SH, Harrison TA, Keku TO, Hudson TJ, Vymetalkova V, Moreno V, Martín V, Arndt V, Wei WQ, Chung W, Su YR, Hayes RB, White E, Vodicka P, Casey G, Gruber SB, Schoen RE, Chan AT, Potter JD, Brenner H, Jarvik GP, Corley DA, Peters U, Hsu L. Genome-wide modeling of polygenic risk score in colorectal cancer risk. Am J Hum Genet. 2020 Jul 29:S0002-9297(20)30236-6. doi: 10.1016/j.ajhg.2020.07.006. [Epub ahead of print]. PubMed

 

Live Healthy

Senior couple at table eating a healthy meal

How to lower your risk of dementia

It’s never too late (or too soon) to take preventive steps.

Prescription overload

Senior adult sitting with glass of water in one hand and  holding medication in other hand

Deprescribing: Less may be more

Dr. Sascha Dublin explains why sometimes not taking medications may be a safer and healthier choice. 

New funding

Senior male patient with doctor in exam room

Grant of over $55M to boost Alzheimer’s, dementia study

Kaiser Permanente Washington will co-lead an expanded ACT Program to better understand the aging brain.

KPWHRI In the Media

In his quarterly column, Eric Larson, MD, MPH, discusses the risk of over-diagnosis and over-treatment for older adults.

The benefits of slow medicine

3rd Act magazine, Fall 2021 (published in August)

Research

ATN brain scan image

Study evaluates biomarker criteria for Alzheimer’s risk

One-third of people classified as ‘highest risk’ may not develop Alzheimer’s disease, study suggests

KPWHRI In the Media

Healthy aging: Building the path to resilience

How to have a healthier relationship with bedtime

3rd Act magazine, Feb/March issue, 2021