Senior investigator and professor of biostatistics Diana Miglioretti, PhD, is committed to improving health care by building the evidence base for personalized cancer screening. To achieve this goal, Dr. Miglioretti pursues a rigorous combination of applied and methodological research. Her work focuses on the benefits and risks of cancer screening and appropriate use of screening and diagnostic tools including medical imaging.
Dr. Miglioretti co-leads the Breast Cancer Surveillance Consortium (BCSC)—a network of breast imaging registries that has the largest and most comprehensive collection of breast cancer screening data in the nation. Established in 1994, the BCSC is currently supported by a $17 million program project grant from the National Cancer Institute. The vast BCSC database includes information on about 12 million film, digital, and 3D mammograms for more than 2.4 million women. The BCSC also has extensive data on newer methods such as digital breast tomosynthesis (also called 3D mammography) and breast MRI (magnetic resonance imaging).
Dr. Miglioretti’s expertise in maximizing the value of the BCSC data includes establishing and evaluating data collection, helping individual sites and outside researchers with analyses, and developing new statistical techniques. In part through her efforts, results from BCSC studies have helped guide national breast cancer screening policy decisions and clinical guidelines. A few examples of Dr. Miglioretti’s BCSC studies are:
Other examples of Dr. Miglioretti’s research include:
In addition to her KPWHRI faculty position, Dr. Miglioretti is the Dean’s Professor of Biostatistics in the Department of Public Health Sciences, School of Medicine, University of California, Davis. She enthusiastically shares her expertise as an instructor at the Radiological Society of North America's (RSNA) annual workshop in clinical trials methodology, which prepares radiologists to develop clinical research protocols and apply for funding.
Among Dr. Miglioretti’s professional memberships are the American Association for Cancer Research, the International Biometrics Society Eastern and Western North America regions, and the American Statistical Association, for which she was elected a fellow.
Clustered and longitudinal data analysis; latent variable modeling; assessment of diagnostic and screening tests
Biostatistics; breast cancer screening and surveillance; mammographic breast density; risk prediction
Imaging trends; radiation exposure from medical imaging; evaluation of imaging tests
Crone NE, Miglioretti DL, Gordon B, Lesser RP. Functional mapping of human sensorimotor cortex with electrocorticographic spectral analysis. II. Event-related synchronization in the gamma band. Am J NonInv Cardiol. 1998;121 ( Pt 12)():2301-15. PubMed
Boatman D, Hart J Jr, Lesser RP, Honeycutt N, Anderson NB, Miglioretti D, Gordon B. Right hemisphere speech perception revealed by amobarbital injection and electrical interference. Neurology. 1998;51(2):458-64. PubMed
Hart J Jr, Crone NE, Lesser RP, Sieracki J, Miglioretti DL, Hall C, Sherman D, Gordon B. Temporal dynamics of verbal object comprehension. Proc Natl Acad Sci U S A. 1998;95(11):6498-503. PubMed
Rathouz PJ, Kasper JD, Zeger SL, Ferrucci L, Bandeen-Roche K, Miglioretti DL, Fried LP. Short-term consistency in self-reported physical functioning among elderly women: the Women's Health and Aging Study. Am J Epidemiol. 1998;147(8):764-73. PubMed
Codori AM, Slavney PR, Young C, Miglioretti DL, Brandt J. Predictors of psychological adjustment to genetic testing for Huntington's disease. Health Psychol. 1997;16(1):36-50. PubMed
Boatman D, Miglioretti DL, Hart J, Lamberti N, Rothlisberger B, Gordon B. Localization and variability in the cortical representation of auditory syllable discrimination and comprehension. Brain and Language. 1996;55(1):150-152.
Bandeen-Roche K, Miglioretti DL, Zeger SL, Rathouz P. Latent variable regression for multiple discrete outcomes. J Am Stat Assoc. 1996;92(440):1375-1386.
Dietz JM, Baker AJ, Miglioretti DL. Seasonal variation in reproduction, juvenile growth, and adult body mass in golden lion tamarins (Leontopithecus rosalia). American Journal of Primatology. 1994;34:115-132.
Buist DM, Ichikawa L, Wernli KJ, Lee CI, Henderson LM, Kerlikowske K, Bowles EJ, Miglioretti DL, Specht J, Rauscher G, Sprague B, Onega T, Lee JM. Facility variability in examination indication among women with prior breast cancer: implications and the need for standardization. J Am Coll Radiol. 2020 Jan 28. pii: S1546-1440(19)31483-8. doi: 10.1016/j.jacr.2019.12.020. [Epub ahead of print]. PubMed
Buist DSM, Tiro JA, Thayer C, Beatty T, Miglioretti DL, Lin J, Winer RL. Improving the promise of embedded pragmatic trials: surmountable barriers encountered in an evaluation of home-based HPV self-sampling to increase cervical cancer screening in overdue women. Contemp Clin Trials Commun. 2019 Jul 19;15:100413. doi: 10.1016/j.conctc.2019.100413. eCollection 2019. PubMed
Dr. Diana Buist and team reflect on HOME trial showing 50 percent screening boost in underscreened women.
Interdisciplinary group shows that home-based HPV tests can boost cervical cancer screening for women at high risk.
A Kaiser Permanente-led BCSC study is among the largest ever to evaluate adding MRI surveillance for breast cancer survivors.
Family history sparks interest for KPWHRI senior investigator, UC Davis professor, and co-leader of the BCSC.
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HealthDay, Nov 8, 2019