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Events

Kaiser Permanente Washington Health Research Institute hosts regular seminars where our scientists and collaborators present their research findings.

All are welcome.

Left: Senior Investigator David Arterburn, MD, MPH

Upcoming seminars and events

 


May 23, 2017

Immigrant and Refugees Health Disparities: Somali Community’s Overview

Where: Kaiser Permanente Washington Health Research Institute, 4–5 p.m., Room 1509A

Presenter: Ahmed Ali, PharmD, Executive Director, Somali Health Board

Summary

King County has a reputation as one the healthiest regions in the nation, but underneath that status lie significant disparities within minority, immigrant and refugee communities. The more than 30,000 Somali immigrants and refugees in King County face tremendous challenges. Consumed with issues of survival and resettlement, new arrivals are focused on finding adequate housing, overcoming trauma and loss, coping with cultural adjustment and learning English.

Much like other new immigrants and refugees, Somali immigrants and refugees have substantial health concerns. At the same time they experience significant barriers to accessing health resources, including unfamiliarity and distrust of the U.S. health care system, lack of language and cultural responsiveness from providers, and competing priorities—particularly given challenges meeting basic, life-sustaining daily needs. This presentation will cover general information on the Somali population in King County, barriers to health care, and Somali Health Board’s roles in addressing these challenges in partnership with the health systems.

Coffee and tea will be served.

 


May 24, 2017

Pragmatic Clinical Trials: Unique Opportunities for Disseminating, Implementing, and Sustaining Evidence-Based Practices into Clinical Care

Where: National Institutes of Health (NIH) in Bethesda, Maryland, Wednesday, May 24 from 8 a.m. to 4:30 p.m. Eastern Time.

Workshop and videocast: Register here

The workshop is based on the lessons learned from nine pragmatic trials initiated through the NIH Health Care Systems Research Collaboratory, which is funded by the NIH Common Fund. Topics addressed included suicide prevention, colorectal cancer screening, care for back pain, advanced care planning, reducing hospital infections, and more.

Speakers for the workshop will include academic researchers and health system partners from across the country and other leaders from Kaiser Permanente, including:

  • Kaiser Permanente Washington President Susan Mullaney, MHA;
  • Kaiser Permanente Washington Health Research Institute (KPWHRI) Senior Investigator Gregory Simon, MD, MPH;
  • Kaiser Permanente Northwest’s Senior Investigators Gloria Coronado, PhD, and
  • Lynn DeBar, PhD, MPH.

Eric B. Larson, MD, MPH, vice president for research and health care innovation for Kaiser Permanente Washington and executive director of KPWHRI, will serve as a moderator and leads the team that organized the NIH workshop with collaboration from Catherine Meyers, MD and others from the NIH, and Leah Tuzzio, MPH and James Fraser from KPWHRI and others from Duke University’s Clinical Research Institute.

 


June 2, 2017

Kaiser Permanente Senior Caucus Meeting 

Where: Kaiser Permanente Capitol Hill campus main building, Sixth floor Sound View Room, 201 16th Ave. E., Seattle, Wash., 10:30 a.m. to noon. 

Dr. Eric Larson will discuss his book Enlightened Aging: Building Resilience for a Long, Active Life. 

Based largely on his decades of research among Kaiser Permanente Washington seniors, the book offers practical advice for staving off disability until very old age. Steps include being proactive, accepting changes that come with age, and building strong physical, mental, and social reserves for a long, active life. 

A expert in the science of aging, Dr. Larson leads the Adult Changes in Thought (ACT) study, one of the world’s largest and longest studies aimed at preventing dementia. He is vice president for research and health care innovation at Kaiser Permanente Washington and executive director of Kaiser Permanente Washington Health Research Institute (KPWHRI). He is also professor of medicine and health services at the University of Washington. 

All are welcome.

 


June 13, 2017

Improving Medication Adherence: Keep Your Eyes on the Prize 

Where: Kaiser Permanente Washington Health Research Institute, 4–5 p.m., Room 1509A

Presenter: Zachary A. Marcum, PharmD, PhD, Assistant Professor, University of Washington, School of Pharmacy

Summary

Dr. Marcum will discuss existing knowledge on the measurement of medication adherence, effective strategies for improving medication adherence, and some of the challenges with conducting research on medication adherence. He will present preliminary results from his K12 career development award, which is a partnership with the Adult Changes in Thought (ACT) Study at KPWHRI.

Coffee and tea will be served.

 


June 27, 2017

Excellence in Primary Care: Lessons from Exceptional Practices

Where: Kaiser Permanente Washington Health Research Institute, 4–5 p.m., Room 1509A

Presenters

  • Brian Austin, Associate Director, MacColl Center for Health Care Innovation
  • Clarissa Hsu, Assistant Investigator, Kaiser Permanente Washington Health Research Institute
  • DeAnn Cromp, Research Associate, Center for Community Health and Evaluation
  • Ed Wagner, Director Emeritus, MacColl Center for Health Care Innovation

Summary
PCT-LEAP (The Primary Care Team: Learning from Effective Ambulatory Practices) is a national program of the Robert Wood Johnson Foundation. There is growing recognition that excellence in primary care depends upon an effective team, yet there is little empiric evidence about the composition of optimal care teams or how they are deployed. In response, PCT-LEAP has tried to fill this gap through the careful selection and study of 30 high-performing American primary care practices that are innovative in their use of their workforce. In the seminar, we will share lessons learned and insights obtained from our studies of these practices.


Past Events

 


May 9, 2017

Amazing ‘Race’: Team NLP/VDW to unmask unknown race/ethnicity

Where: Kaiser Permanente Washington Health Research Institute, 4–5 p.m., Room 1509A

Speakers

  • Jane Grafton, Programmer, Kaiser Permanente Washington Health Research Institute
  • David Cronkite, Programmer, Kaiser Permanente Washington Health Research Institute
  • Onchee Yu, Biostatistician, Kaiser Permanente Washington Health Research Institute

Summary
Race and ethnicity is an important risk factor on many health conditions. At KPWHRI, we often rely on VDW demographics table to collect race/ethnicity data. Depending on the study years, the amount of missingness in race/ethnicity in the study cohort could be large. In our study of estimating a 10-year incidence of uterine fibroid that varies by race/ethnicity, we utilized NLP to supplement unknown race/ethnicity from VDW. We’ll discuss the NLP development process, and how the resulting race/ethnicity data from the two data sources compared.

Coffee and tea will be provided.

 


April 28, 2017

Compelling Science Storytelling: A Pacific Northwest Workshop for Science Communicators

A one-day workshop and networking opportunity in Seattle

WhereFred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Wash.

This is a one-day workshop and networking opportunity in Seattle for science communicators and public information officers.

The regional conference is supported by the National Association of Science Writers and hosted by Fred Hutchinson Cancer Research Center.

Kaiser Permanente Washington Health Research Institute is proud to be a co-sponsor of this event. Other organizers include science writers and public information specialists from Fred Hutchinson Cancer Research Center, Institute for Health Metrics and Evaluation (IHME), Pacific Northwest National Laboratory, PATH, Public Health–Seattle & King County, Seattle Children’s Research Institute, University of Washington, and Washington Global Health Alliance.

The workshop has proven so popular the event has reached capacity, so registrations are now closed.

Read more on the Workshop Program page. Questions? Contact: storytelling2017@nwscience.org. Follow on Twitter at @scistories17

 


April 25, 2017

Accelerating Research in a Learning Health Care System: An Overview and Exemplars of VA’s Quality Enhancement Research Initiative

Where: Kaiser Permanente Washington Health Research Institute, 4–5 p.m., Room 1509A

PresentersKathy Bradley, MD, PhD, Senior Investigator, Kaiser Permanente Washington Health Research Institute; John Fortney, PhD, Professor, Psychiatry & Behavioral Health, Adjunct Professor, Health Services, School of Public Health, University of Washington; Christian Helfrich, PhD, MPH, Research Associate Professor, Health Services, School of Public Health, University of Washington 

Abstract
The VA has supported rapid implementation of research into clinical practice since 1998 when the Quality Enhancement Research Initiative (QUERI) was formed. KPWHRI’s own Kathy Bradley will describe QUERI’s early structure and impact (1998-2011).  With the passage of the Choice Act in 2014, the QUERI was transformed to support a Learning Health Care System by aligning science and funding with clinical priorities identified through strategic planning. Two principal investigators from the VA in Puget Sound will provide an overview on the new structure and drill down into their recently funded QUERI programs to reveal how rigorous evaluation and scientific testing of implementation strategies can reduce care quality variability and improve population health. John Fortney will describe the Virtual Specialty Care QUERI Program: Implementing and Evaluating Technology Facilitated Clinical Interventions to Improve Access to High Quality Specialty Care for Rural Veterans. Christian Helfrich will describe the Improving Safety and Quality through Evidence-Based De-Implementation of Ineffective Diagnostics and Therapeutics program. This session will be followed by a KPWHRI internal discussion of how we might pull from the QUERI structure and exemplars to enhance our own Learning Health Care System (date TBD).

 


April 11, 2017

The Learning to Integrate Neighborhoods and Clinical Care (LINCC Project): Creating a New Role in Primary Care Teams to Engage Patients and Communities in Addressing the Social Determinants of Health

Where: Kaiser Permanente Washington Health Research Institute, 4–5 p.m., Room 1509A

PresenterClarissa Hsu, PhD, Assistant Investigator, Center for Community Health and Evaluation, Kaiser Permanente Washington Health Research Institute, and other members of the LINCC team

Abstract
We will report on our experiences and results implementing the LINCC project. The project aims were to:

  1. develop, implement, and evaluate intense involvement of patients in the design of a new primary care role to link patients to community resources;
  2. design and pilot the new role of in clinics;
  3. and conduct a robust evaluation of the implementation of the role.

Patient involvement in the design of the Community Resource Specialist (CRS) role was evaluated using observation of design events, interviews and surveys of participants, and interviews of health system leaders. Implementation and impact of the CRS role was evaluated using data from staff interviews, patient focus groups, clinic site visits, patient surveys, documentation from the electronic health record (EHR) and administrative data.

This presentation will highlight our findings and explore the benefits and challenges of designing, implementing and evaluating interventions in real world settings. We found that involving patients as partners in designing the new role for primary care was well-received by both patients and health system representatives. The new CRS role earned high patient satisfaction scores. Patients who used the CRS services and participated in focus groups reported behavior changes and improved health, although no changes were detected in the patient survey data. Our experiences addressing the challenges and limitations we encountered provide valuable lessons regarding research-delivery system partnerships and ways to improve the design and evaluation of clinic-based interventions to address social determinants of health going forward. 

 


March 28, 2017

Do Complete Streets Policies Cause Bike Fatalities while Decreasing Cyclist Fatality Risk?

Kaiser Permanente Washington Health Research Institute, Room 1509A, 4–5 p.m.

Presenter: Steve Mooney, PhD, completed a PhD in epidemiology at Columbia University in 2016. His substantive research focuses on built environment determinants of physical activity and injury, but he aspires to be an epidemiology methodologist as well.

Abstract

"Complete Streets" policies requiring transportation engineers to make provisions for pedestrians, cyclists, and transit users may make cycling safer for each cyclist while increasing overall fatalities by encouraging cycling. We estimate the impact of Complete Streets on cyclist fatality rates, using the parametric g-formula to account for the size of the cycling population under different levels of exposure.

Coffee and tea will be provided.


March 15, 2017

Families as Consumers: Impact of Strategies to Increase Insurance Coverage and Contain Costs

Kaiser Permanente Washington Health Research Institute, Room 1509A, 3–4 p.m.

Presenter: Alison Galbraith, MD, MPH, Assistant Professor in the Department of Population Medicine at Harvard Medical School and the Harvard Pilgrim Health Care Institute

Abstract

There has been an increasing movement in recent years to promote consumerism in health care. As part of the ACA, health insurance exchanges provide a marketplace for families to shop for coverage and compare plan options based on price, network, and other attributes. So-called consumer-directed health plans with high deductibles have become increasingly prevalent as a means to provide affordable coverage options and contain costs. Price transparency has been promoted by states and payers in an attempt to provide information for patients to make cost-conscious decisions. This talk will explore evidence on the impact of these strategies on family decision making, health care use, and will assess the degree to which families behave as consumers related to health care.

Coffee and tea will be provided.


March 14, 2017

Evaluation of Group Health Risk Reduction Initiatives for Chronic Opioid Therapy Patients (2006-2014): Use of survey, EHR, and state records data for controlled evaluation of health plan initiatives

Kaiser Permanente Washington Health Research Institute, Room 1509A, 4–5 p.m.

Presenter: Michael Von Korff, ScD, Senior Investigator, Kaiser Permanente Washington Health Research Institute

Abstract

We will report results of an evaluation of two major initiatives in the Group Health Integrated Group Practice (GH-IGP) to reduce risks among Chronic Opioid Therapy (COT) patients: (1) dose reduction implemented in mid-2007; and, (2) risk stratification and closer monitoring, implemented in Fall, 2010. The comparison group was COT patients from Group Health Contracted Care (GH-CC) clinics. Using interrupted time series methods, with 22,673 GH-IGP COT patients and 8,469 GH-CC COT patients, we examined adverse events, including opioid overdose (fatal and non-fatal), motor vehicle accidents ascertained with Department of Motor Vehicle records, and medically attended injuries. Using a telephone survey of prevalent COT patients using opioids regularly in GH-IGP or GH-CC for at least one year in 2014-15, we assessed pain severity, perceptions of opioid helpfulness, prevalence of prescription opioid use disorder assessed according to DSM5 criteria, and perceptions of doctor-patient collaboration pertaining to opioid management.

Survey data assessed differences in pain outcomes and problems with opioids comparing COT patients exposed to both risk reduction initiatives (N=935 COT patients from GH-IGP) or to neither health plan risk reduction initiative (N=653 COT patients from GH-CC). This evaluation demonstrates the potential for evaluation of major health plan initiatives using a combination of longitudinal electronic health care data and state records, and cross-sectional survey data. While this evaluation was conducted comparing Group Health Integrated Group Practice and Contracted Care settings, these methods would be well suited to evaluations comparing process and outcome changes over time for quality improvement initiatives implemented in one Kaiser region but not in another Kaiser region serving comparable patients.

Coffee and tea will be provided.


February 28, 2017

Actions and processes that patients, family members, and physicians associate with patient- and family-centered care

Group Health Research Institute, Room 1509A, 4–5 p.m.

Presenter: Clarissa Hsu, PhD, Group Health Research Institute Assistant Investigator

Abstract

Promoting patient- and family -centered care has become increasingly important in health care. However, the specific actions and/or processes needed to achieve this type of care are unclear, particularly in ambulatory, primary care environments.

To fill this knowledge gap, we conducted focus groups with patients, family members, and physicians in three major U.S. cities to elicit specific actions that health care teams can take to provide optimal patient- and family-centered care (PFCC). We identified a detailed list of specific actions that patients, family members, and physicians associate with PFCC.

This paper elaborates on actions associated with the core concepts of dignity and respect—terms often referred to, but that have been difficult to operationalize. Our work is a critical step toward identifying and measuring PFCC in ambulatory care settings. Applications of our findings include supporting research on whether PFCC affects clinical outcomes, and developing innovative PFCC-oriented policies to support PFCC.

Coffee and tea will be provided.


February 14, 2017

Advancing from the activated patient to the autonomous patient in chronic illness care

Group Health Research Institute, Room 1509A, 4–5 p.m.

Presenter: Mark Daniel Sullivan M.D., UW Medicine

Abstract

It is recognized that patients play a central role in chronic illness care, but the concept of health behavior retards innovation. We seek not just an activated patient, but an autonomous patient who sets and pursues her own vital goals. To fully enlist patients, we must bridge the gap between impersonal disease processes and personal processes. This requires understanding how the roots of patient autonomy lie in the biological autonomy that allows organisms to carve their biological niche. It is time for us to recognize the patient as the primary customer for health care and the primary producer of health. Patient agency is both the primary means and primary end of health care.

Bio

Dr. Mark Sullivan received his M.D. and his PhD in Philosophy from Vanderbilt University. After completing an internship in Family Medicine at University of Missouri, he completed a residency in Psychiatry at the University of Washington in 1988. He is now Professor of Psychiatry and Behavioral Sciences as well as Adjunct Professor of Anesthesiology and Pain Medicine and Adjunct Professor of Bioethics and Humanities at the University of Washington.

Dr. Sullivan has served as attending physician in the UW Center for Pain Relief for more than 25 years, where he is Co-Director of Behavioral Health Services. He has published more than 250 peer-reviewed articles. He has been chair of the Ethics Committee of the American Pain Society and on the editorial board of Pain. He has a new book from Oxford University Press titled, "The Patient as Agent of Health and Health Care."

Coffee and tea will be provided.


January 30, 2017

Webinar: Introducing NIMAA

Register here

An Introduction to the National Institute for Medical Assistant Advancement.

When: 2:00 p.m.–3:00 p.m. EST / 11:00 a.m.–12:00 p.m. PST

Recruiting for NIMAA's second year class has begun. Learn about a groundbreaking new way to train key primary care team members for national leaders, including:

You'll also hear from representatives of health centers in Colorado and Connecticut that piloted the first year class. This training furthers MacColl’s ongoing commitment to working in the safety net. Learn more about the Safety Net Medical Home Initiative


January 24, 2017

Evaluating Implementation Processes and Outcomes at GHRI and Beyond

Presenter: Cara C. Lewis, PhD, Group Health Research Institute Associate Investigator

Group Health Research Institute, Room 1509A, 4 p.m. to 5 p.m.

The effectiveness-implementation hybrid study blends design components of clinical effectiveness and implementation research. Its structure has the potential to enhance knowledge development and application of clinical interventions and implementation strategies in “real world” settings.

In this seminar, Dr. Lewis will reconceptualize two GHRI investigator-led projects as effectiveness-implementation hybrids, in order to reveal opportunities for more quickly bringing changes from research into practice for a positive impact on patients. The seminar also aims to generate knowledge about ways to integrate evidence-based practices into healthcare delivery systems.

Learning objectives:

• Gain exposure to three commonly used implementation models.
• Learn how to apply an implementation outcomes framework.
• Review three effectiveness-implementation hybrid case studies.


January 16, 2017

Mindfulness 101—Resources and self-maintenance tips, with Drs. Elizabeth Lin and Kim Holland

Garfield High School Commons, Seattle, Monday, January 16 at 9:30–10:50 a.m.

As two community docs, we are pleased to share some tools and inform you of resources that may help you learn how to breathe, create focus and have fun staying calm when your work, professional and social lives are very busy. We believe the disciplined practice of Mindfulness-Based Stress Reduction (MBSR) is one way to address the trauma of everyday life and the disparities in health outcomes that exist in 2017 in striking similarity to the problems of 50 years ago.

Science shows that daily practice of the disciplines of MBSR has these benefits:

  • Reduce stress and chronic pain. 
  • Improve mood. 
  • Overcome sleep problems. 
  • Decrease anxiety. 
  • Increase immunity. 
  • Enhance resilience, joy and compassion. 

We introduce the practice of MBSR as one way to promote a community of emotional safety and harness the power and discipline of nonviolence as a health care imperative. The session is limited to adults and the first 20 persons.

Presenters:
Dr. Kim Ionia Holland was one of four black teens who were shot in 1970 by a young white man during protests against police actions in New Bedford, Massachusetts. "We offer an opportunity to seek personal wellbeing, health, justice and reconciliation in the daily practice of MBSR."

Elizabeth H. Lin, MD, is a family medicine physician, a researcher of mind-body health, and a certified Mindfulness-Based Stress Reduction (MBSR) facilitator. Dr. Lin's research on improving depression and anxiety introduced her to the health benefits of mindfulness. She has a daily meditation practice for 25 years, and has learned directly from the founders of evidence-based mindfulness, and compassion/self-compassion programs. Over the past five years, Dr. Lin has been teaching mindfulness and mindful self-compassion courses.


January 10, 2017

UW School of Nursing Research, exploring areas of potential collaboration

Presenters: JoAnne Whitney, PhD, RN, CWCN, FAAN, Tatiana Sadak, PhD, ARNP, PMHNP, Oleg Zaslavasky, PhD, and Kerryn Reding, PhD, MPH—UW School of Nursing

Group Health Research Institute, Room 1509A, 4 p.m. to 5 p.m.

Abstract:

In the session we will share an overview of our research priority areas ( Health Equity, Innovative Methods and Interventions, Lifespan Health, Symptom Science) and strengths and highlight current research projects of the three presenters in dementia care/caregivers of patients with dementia, healthy aging for frail elders and cancer.

The UW SoN typically has $12–15 million in external funding annually (grants with UW SoN faculty as PI) and many other inter-professional collaborations as co-investigators on initiatives. We are very interested in exploring common interests that may lead to future collaborations and connections. 

Biographies:

JoAnne Whitney, PhD, RN, CWCN, FAAN, is Professor of Nursing University of Washington, School of Nursing, Associate Dean for Research and Nurse Scientist at Harborview Medical Center, Seattle. She is co-director for the ITHS TL1 multidisciplinary predoctoral translational research training program (NIH NCATS) and the ITHS Rising Stars mentoring program for early career faculty. Education: BSN Duke University, MS University of Michigan, PhD University of California, San Francisco. Her 30+year research program addresses acute and chronic wounds, including tissue oxygen, perfusion, stress and healing, pressure ulcers, surgical site infection, warming, and mHealth. She is a member of the Western Academy of Nursing and the American Academy of Nursing.

Tatiana Sadak PhD, ARNP, PMHNP, is an Assistant Professor of geriatric mental health at the UW School of Nursing and a neurodegenerative disorders specialist at the Psychiatric Wellness and Dementia Care Clinic. Tatiana is a recipient of John A Hartford and Robert Wood Johnson foundation fellowship awards. She is currently a PI on several NIH funded grants that focus on improving dementia family/friend caregiver activation (readiness, knowledge and skills to manage care recipient's health while maintaining personal wellness) and on creating palliative care pathways and services tailored for dementia patient/caregiver dyads. Dr. Sadak's manuscript about developing caregiver activation measures recently received Springer Publishing award. She is a member of the WA Alzheimer's Plan and the Bree Collaborative workgroups.

Oleg Zaslavasky, PhD, is Assistant Professor of Nursing University of Washington, School of Nursing, Associate Director of Research, de Tornyay Center for Healthy Aging. Education: BSN Haifa University, Israel, MHA Tel Aviv University, Israel, PhD University of Washington, Seattle. His program of research has three interrelated foci: assessing and improving outcomes in older persons at risk for and with frailty; understanding and promoting health equity and healthy aging in communities; and examining the ways in which innovative informatics methods improve outcomes in older and frail persons

Kerryn Reding, PhD, MPH, is an Assistant Professor in the Department of Biobehavioral Nursing and Health Informatics at the University of Washington School of Nursing. Her research focuses on biobehavioral mechanisms and health disparities in health promotion and cancer survivorship.  She is currently the PI of a pilot study to examine a multi-level health promotion intervention for underserved communities, as well as a study to investigate the risk of breast cancer associated with a novel estrogen biomarker in the Women’s Health Initiative. Her research goals are to contribute an understanding of biobehavioral pathways related to nutrition and physical activity, and their influence on multiple chronic conditions.

Coffee and tea will be provided.


December 13, 2016

Comparative safety of sulfonylureas: Clinical sequelae of K(ATP) blockade

Presenter: Charles E. Leonard, PharmD, MSCE: Research Assistant Professor, Biostatistics and Epidemiology, Perelman School of Medicine 

Group Health Research Institute, Room 1509A, 4 p.m. to 5 p.m.

Abstract:

Sulfonylureas remain important in the armamentarium of clinicians treating type 2 diabetes mellitus. Agents within this drug class are at least initially effective, generally well tolerated, and inexpensive. Yet, there are major concerns for serious hypoglycemia and untoward cardiovascular effects. To help inform second-line antidiabetic therapy prescribing decisions, it is critical to understand the safety of individual sulfonylureas. This talk will examine Dr. Leonard’s pharmacoepidemiologic studies elucidating adverse effects of sulfonylureas, including investigations of:

a) serious hypoglycemia potentiated by drug interactions; and

b) sudden cardiac arrest.

Coffee and tea will be served.


November 28, 2016

Accelerated failure time models in the presence of complex censoring with application to Alzheimer’s disease

Presenter: Sebastien Haneuse, PhD, Associate Professor of Biostatistics, Harvard T.H. Chan School of Public Health

Group Health Research Institute, Room 1509A, 10 a.m. to 11 a.m.

Abstract:
Statistical analyses that investigate risk factors for Alzheimer’s disease (AD) are often subject to a number of challenges. Some of these challenges arise due to practical considerations regarding data collection such as when the observation of AD events and time-varying exposures is subject to complex censoring including left truncation and either interval or right censoring. Additional challenges arise due to the fact that study participants are often subject to competing forces, most notably death, that may not be independent of AD.

Toward resolving the latter, researchers may choose to embed the study of AD within the “semi-competing risks” framework for which the recent statistical literature has seen a number of advances including for the so-called illness-death model. To the best of our knowledge, however, the semi-competing risks literature has not fully considered analyses in contexts with complex censoring, as in typical studies of AD. This is particularly the case when interest lies in the accelerated failure time (AFT) model, an alternative to the traditional multiplicative Cox model that places emphasis away from the hazard function. In this work we outline a new Bayesian framework for estimation/inference of an AFT illness-death model for semi-competing risks data subject to complex censoring. An efficient computational algorithm that gives researchers the flexibility to adopt either a fully parametric or a semi-parametric model specification is developed and implemented.

The proposed methods are motivated by and illustrated with an analysis of data from the Adult Changes in Thought study, an on-going community-based prospective study of incident AD in western Washington State.

Coffee and tea will be served.

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