Linda K. McEvoy, PhD, is an experimental psychologist and neuroscientist with acquired expertise in aging epidemiology. As a senior investigator at Kaiser Permanente Washington Health Research Institute (KPWHRI) and professor emerita at the University of California San Diego, Dr. McEvoy works to improve the understanding of cognitive and brain changes in typical aging and in neurodegenerative disorders such as Alzheimer’s disease. Her mission is to better understand the factors throughout the life course that affect cognitive and brain health in aging, in order to develop strategies to maintain cognitive health and reduce risk of dementia.
Before joining KPWHRI, Dr. McEvoy was a professor of public health and radiology at UC San Diego, where she conducted research on longitudinal cohort studies to identify typical patterns of changes in brain structure with aging and to distinguish them from patterns associated with early Alzheimer’s disease. Her research also sought to identify genetic, health, and behavioral risk factors associated with higher rates of cognitive decline with age and with dementia.
She was one of the principal investigators on the Rancho Bernardo Study of Healthy Aging, initiated in 1972. She assumed a leadership role on this study in 2014, expanding data collection to include neuroimaging and directing the electronic archiving and sharing of the vast amount of data collected by this study. She was also an investigator on the Vietnam Era Twin Study of Aging — a national study of male twin pairs who were recruited into the military during the Vietnam War era and who have been followed from middle age into older age.
More recently, using data from the Women’s Health Initiative, Dr. McEvoy has expanded her research focus to examine blood-based measures, including proteomic and epigenetic factors, that may predict risk of cognitive decline and dementia. At KPWHRI, she continues to study factors across the life course that influence cognitive health as a lead investigator on the ground-breaking Adult Changes in Thought (ACT) Study.
In addition to her research, Dr. McEvoy enjoys mentoring students, fellows, and junior faculty. At UC San Diego, she had leadership roles on several aging and Alzheimer’s disease training programs funded by the National Institutes of Health (NIH), and she taught courses in grant writing to junior faculty. She enjoys sharing her knowledge on the characteristics of successful grant applications, which she has accumulated through service on several NIH study sections, including her current service as a standing member of the Center for Scientific Review Adult Psychopathology and Disorders of Aging Study Section.
Posis AIB, Yarish NM, McEvoy LK, Jain P, Kroenke CH, Saquib N, Ikramuddin F, Schnatz PF, Bellettiere J, Rapp SR, Espeland MA, Shadyab AH. Association of social support with mild cognitive impairment and dementia among older women: The Women's Health Initiative Memory Study. J Alzheimers Dis. 2023;91(3):1107-1119. doi: 10.3233/JAD-220967. PubMed
Gustavson, DE, Archer, DB, Elman, JA, Puckett, OK, Fennema-Notestine C, Panizzon MS, Shashikumar N, Hohman TJ, Jefferson AL, Eyler LT, McEvoy, LK, Lyons, MJ, Franz CE, Kremen WS. Associations among executive function abilities, free water, and white matter microstructure in early old age. Neuroimage Clin. 2023;37:103279. doi: 10.1016/j.nicl.2022.103279. Epub 2022 Dec 1. PubMed
Williams ME, Gillespie NA, Bell TR, Dale AM, Elman JA, Eyler LT, Fennema-Notestine C, Franz CE, Hagler DJ Jr, Lyons MJ, McEvoy LK, Neale MC, Panizzon MS, Reynolds CA, Sanderson-Cimino M, Kremen WS. Genetic and environmental influences on structural- and diffusion-based Alzheimer's disease neuroimaging signatures across midlife and early old age. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Jun 20;S2451-9022(22)00151-3. doi: 10.1016/j.bpsc.2022.06.007. PubMed
McEvoy LK, Bergstrom J, Tu X, Garduno AC, Cummins KM, Franz CE, Lyons MJ, Reynolds CA, Kremen WS, Panizzon MS, Laughlin GA. Moderate alcohol use is associated with reduced cardiovascular risk in middle-aged men independent of health, behavior, psychosocial, and earlier life factors. Nutrients. 2022 May 24;14(11):2183. doi: 10.3390/nu14112183. PubMed
Garduno AC, Laughlin GA, Bergstrom J, Tu XM, Cummins KM, Franz CE, Elman JA, Lyons MJ, Reynolds CA, Neale MC, Gillespie NA, Xian H, McKenzie RE, Toomey R, Kremen WS, Panizzon MS, McEvoy LK. Alcohol use and cognitive aging in middle-aged men: The Vietnam Era Twin Study of Aging. J Int Neuropsychol Soc. 2023 Mar;29(3):235-245. doi: 10.1017/S1355617722000169. Epub 2022 Apr 25. PubMed
The ACT Research Symposium returns with an in-person scientific forum.
For over 30 years, the Adult Changes in Thought (ACT) Study has been advancing our understanding of cognition, aging, and better ways to delay and prevent Alzheimer’s disease and related dementias.
Cell by cell, scientists are building a high-resolution map of brain changes in Alzheimer’s disease.