Linda K. McEvoy, PhD, is a senior investigator at Kaiser Permanente Washington Health Research Institute (KPWHRI) and professor emerita at the University of California (UC) San Diego. Dr. McEvoy uses epidemiological approaches to improve the understanding of cognitive and brain changes in typical aging and in neurodegenerative disorders such as Alzheimer’s disease. Her mission is to better understand the factors that may affect cognitive and brain health in aging, with the goal of informing strategies to maintain cognitive health and reduce dementia risk. These factors include genetic, health, behavioral, environmental, and psychosocial exposures across the life course.
Dr. McEvoy joined KPWHRI in 2023 to take over leadership of the ground-breaking Adult Changes in Thought (ACT) Study following the retirement of the study’s founder, Dr. Eric Larson. ACT is a large, longitudinal study of members of Kaiser Permanente Washington that began in1994 and has created a rich resource for the aging research community to examine factors that affect cognitive and brain health in aging.
In addition to her work on the ACT Study, Dr. McEvoy also performs research using data from the Women’s Health initiative, examining blood-based biomarkers of dementia risk, including epigenetic and proteomic measures.
Dr. McEvoy enjoys mentoring students, fellows, and junior faculty. At UC San Diego, she had leadership roles on several aging and Alzheimer’s disease training programs funded by the National Institutes of Health (NIH), and she taught courses in grant writing to junior faculty. She enjoys sharing her knowledge on the characteristics of successful grant applications, which she has accumulated through service on several NIH study sections.
Tibiriçá L, Jester DJ, Kohn JN, Williams AP, McEvoy LK, Palmer BW Perceived discrimination and nativity status: risk of cognitive impairment among Latin American older adults 2024 Sep;36(9):818-830. doi: 10.1017/S1041610223004374. Epub 2023-12-01. PubMed
Nguyen S, McEvoy LK, Espeland MA, Whitsel EA, Lu A, Horvath S, Manson JE, Rapp SR, Shadyab AH Associations of Epigenetic Age Estimators With Cognitive Function Trajectories in the Women's Health Initiative Memory Study 2024 Jul 9;103(1):e209534. doi: 10.1212/WNL.0000000000209534. Epub 2024-06-10. PubMed
Posis AIB, Alcaraz JE, Parada H, Shadyab AH, Elman JA, Panizzon MS, Reynolds CA, Franz CE, Kremen WS, McEvoy LK Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging 2024 Jun 17;5(1):563-573. doi: 10.1089/neur.2024.0034. Epub 2024-06-17. PubMed
Reas ET, Triebswetter C, Banks SJ, McEvoy LK Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status 2024 Jan 11;16(1):7. doi: 10.1186/s13195-023-01380-w. Epub 2024-01-11. PubMed
Posis AIB, Shadyab AH, Parada H, Alcaraz JE, Kremen WS, McEvoy LK Multimorbidity, Social Engagement, and Age-Related Cognitive Decline in Older Adults from the Rancho Bernardo Study of Healthy Aging 2024 Jan;97(4):1689-1702. doi: 10.3233/JAD-230809. PubMed
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