Andrea J. Cook, PhD

“National interest in using data to improve patient care and safety is growing. Our group is developing the biostatistical methods for that work.”

Andrea J. Cook, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute

Biography

Andrea Cook, PhD, is a biostatistician whose work focuses on leveraging available data such as electronic health records (EHRs) to efficiently address important public health questions and improve the overall health of our population. Dr. Cook has developed research methods using EHRs and other existing health care data for major initiatives led by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA). Her work spans many areas, including hypertension control, cancer screening, renal disease therapies, and alternative medicine for pain.

The goal of Dr. Cook’s research is finding interventions that improve patient care. She studies how pragmatic clinical trials, which are conducted under real-world conditions in health care organizations such as Kaiser Permanente Washington, can deliver more effective care and improve patient outcomes. Dr. Cook is a lead biostatistician for the Biostatistics and Study Design Core of the NIH Collaboratory, which facilitates the implementation of pragmatic clinical trials. She addresses the numerous statistical challenges of pragmatic clinical trials including how to design studies to answer research questions without impeding the delivery of care and how to use EHRs for more cost-effective studies. 

Dr. Cook also studies how to use EHR data to improve the way we monitor the safety of new medical products including vaccines, drugs, and medical devices. She contributes to the FDA Sentinel Initiative and the CDC Vaccine Safety Datalink and has led the development of new statistical methods for actively monitoring medical products for rare adverse events using distributed data networks.

Dr. Cook obtained her PhD in biostatistics from the Harvard T.H. Chan School of Public Health in 2005. She is a member of the American Statistical Association and the Western North American Region of the International Biometric Society. She is also an affiliate associate professor in biostatistics at the University of Washington.

Research interests and experience

Recent publications

Cook AJ, Wellman RD, Marsh T, Shoaibi A, Tiwari R, Nguyen M, Boudreau D, Weintraub ES, Jackson L, Nelson JC. Applying sequential surveillance methods that use regression adjustment or weighting to control confounding in a multi-site, rare event, distributed setting: part 2: in-depth example of a re-analysis of the measles-mumps-rubella-varicella combination vacc J Clin Epidemiol. 2019 May 2. pii: S0895-4356(17)31414-2. doi: 10.1016/j.jclinepi.2019.04.019. [Epub ahead of print]. PubMed

Drewnowski A, Arterburn D, Zane J, Aggarwal A, Gupta S, Hurvitz PM, Moudon AV, Bobb J, Cook A, Lozano P, Rosenberg D. The Moving to Health (M2H) approach to natural experiment research:a paradigm shift for studies on built environment and health. SSM Popul Health. 2018 Dec 28;7:100345. doi: 10.1016/j.ssmph.2018.100345. eCollection 2019. PubMed

Shortreed SM, Cook AJ, Coley RY, Bobb JF, Nelson JC. Challenges and opportunities for using big health care data to advance medical science and public health. Am J Epidemiol. 2019 Mar 16. pii: 5381891. doi: 10.1093/aje/kwy292. [Epub ahead of print]. PubMed

Shortreed SM, Rutter CM, Cook AJ, Simon GE. Improving pragmatic clinical trial design using real-world data. Clin Trials. 2019 Mar 13:1740774519833679. doi: 10.1177/1740774519833679. [Epub ahead of print]. PubMed

 

News release

Mindfulness meditation eases chronic low back pain

 
March 22, 2016—JAMA publishes randomized controlled trial by Group Health researchers, comparing mindfulness, cognitive behavioral therapy, and usual care for back pain.
 
Read it in News and Events.

video

Cherkin-Newsrelease-Mindfulness_1col.jpg

Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy for Chronic Low Back Pain

(JAMA Network, 2:26)

 

KPWHRI In the Media

Mindfulness meditation eases chronic low back pain

Mind-based therapies may ease lower back pain

New York Times, March 22, 2016

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