Andrea J. Cook, PhD

“National interest in using data to improve patient care and safety is growing. Our group is developing the biostatistical methods for that work.”

Andrea J. Cook, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute

Biography

Dr. Andrea Cook understands that leveraging available data such as electronic health records is vital if we want to efficiently address important public health questions and improve the overall health of our population. Dr. Cook uses her biostatistics expertise to develop research methods using existing health care system and electronic health data. Her methods are used in major initiatives for the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA). She has worked on numerous studies in areas including hypertension control, cancer screening, renal disease therapies, and alternative medicine for pain.

Dr. Cook is studying how pragmatic clinical trials, which are conducted under real-world conditions in health care organizations such as Kaiser Permanente Washington, can deliver more effective care and improve patient outcomes. She is a lead biostatistician for the Biostatistics and Design Core of the NIH Collaboratory, which facilitates the implementation of pragmatic clinical trials. Dr. Cook addresses the numerous statistical challenges of pragmatic clinical trials including how to design studies to answer research questions without impeding the delivery of care and how to use electronic health records for more cost-effective studies. The goal of Dr. Cook’s research is finding interventions that improve patient care.   

Dr. Cook also studies how to use electronic medical data to improve the way we monitor the safety of new medical products including vaccines, drugs, and medical devices. She contributes to the FDA Sentinel Initiative and the CDC Vaccine Safety Datalink with KPWHRI colleagues including Director of Biostatistics Jennifer Nelson, PhD, and Robert Wellman, MS, and colleagues from the University of Washington and Harvard Medical School. Dr. Cook has led the development of new statistical methods for actively monitoring medical products for rare adverse events using distributed data networks.

Dr. Cook obtained her PhD in 2005 from the Biostatistics department at the Harvard T.H. Chan School of Public Health. She is a member of the American Statistical Association, the Western North American Region of the International Biometric Society, and an affiliate associate professor in biostatistics at the University of Washington.

Research interests and experience

Recent publications

McClure JB, Blasi PR, Cook A, Bush T, Fishman P, Nelson J, Anderson ML, Catz SL. Oral health 4 life: design and methods of a semi-pragmatic randomized trial to promote oral health care and smoking abstinence among tobacco quitline callers. Contemp Clin Trials. 2017 Apr 12. pii: S1551-7144(16)30427-X. doi: 10.1016/j.cct.2017.04.003. [Epub ahead of print]. PubMed

Cherkin DC, Anderson ML, Sherman KJ, Balderson BH, Cook AJ, Hansen KE, Turner JA. Two-year follow-up of a randomized clinical trial of mindfulness-based stress reduction vs cognitive behavioral therapy or usual care for chronic low back pain. JAMA. 2017;317(6):642-644. doi: 10.1001/jama.2016.17814. PubMed

Turner JA, Anderson ML, Balderson BH, Cook AJ, Sherman KJ, Cherkin DC. Mindfulness-based stress reduction and cognitive-behavioral therapy for chronic low back pain: similar effects on mindfulness, catastrophizing, self-efficacy, and acceptance in a randomized controlled trial. Pain. 2016 Nov;157(11):2434-2444.doi:10.1097/j.pain.0000000000000635. PubMed

Parchman ML, Fagnan LJ, Dorr DA, Evans P, Cook AJ, Penfold RB, Hsu C, Cheadle A, Baldwin LM, Tuzzio L. Study protocol for "Healthy Hearts Northwest": a 2 x 2 randomized factorial trial to build quality improvement capacity in primary care. Implement Sci. 2016 Oct 13;11(1):138. PubMed

 

News release

Mindfulness meditation eases chronic low back pain

 
March 22, 2016—JAMA publishes randomized controlled trial by Group Health researchers, comparing mindfulness, cognitive behavioral therapy, and usual care for back pain.
 
Read it in News and Events.

video

Cherkin-Newsrelease-Mindfulness_1col.jpg

Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy for Chronic Low Back Pain

(JAMA Network, 2:26)

 

KPWHRI In the Media

Mindfulness meditation eases chronic low back pain

Mind-based therapies may ease lower back pain

New York Times, March 22, 2016

Healthy Communities

What if a street map could show how healthily people eat?

UW and GHRI researchers have come up with innovative maps that illustrate the link between wealth accumulation and diet quality. 

Vaccine Safety

Vaccine Safety Datalink