Andrea J. Cook, PhD

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“National interest in using data to improve patient care and safety is growing. Our group is developing the biostatistical methods for that work.”

Andrea J. Cook, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute

Andrea.J.Cook@kp.org
206-287-4257

Biography

Andrea Cook, PhD, is a biostatistician whose work focuses on leveraging available data such as electronic health records (EHRs) to efficiently address important public health questions and improve the overall health of our population. Dr. Cook has developed research methods using EHRs and other existing health care data for major initiatives led by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the U.S. Food and Drug Administration (FDA). Her work spans many areas, including hypertension control, cancer screening, obesity, diabetes, built environment, and alternative medicine for pain.

The goal of Dr. Cook’s research is finding interventions that improve patient care. She studies how pragmatic clinical trials, which are conducted under real-world conditions in health care organizations such as Kaiser Permanente Washington, can deliver more effective care and improve patient outcomes. Dr. Cook is a lead biostatistician for the Biostatistics and Study Design Core of the NIH Collaboratory, which facilitates the implementation of pragmatic clinical trials. She addresses the numerous statistical challenges of pragmatic clinical trials including how to design studies to answer research questions without impeding the delivery of care and how to use EHRs for more cost-effective studies.

Dr. Cook also studies how to use EHR data to improve the way we monitor the safety of new medical products including vaccines, drugs, and medical devices. She contributes to the FDA Sentinel Initiative and the CDC Vaccine Safety Datalink and has led the development of new statistical methods for actively monitoring medical products for rare adverse events using distributed data networks.

Dr. Cook obtained her PhD in biostatistics from the Harvard T.H. Chan School of Public Health in 2005. She is a member of the American Statistical Association and the Western North American Region of the International Biometric Society. She is also an affiliate professor in biostatistics at the University of Washington.

Research interests and experience

Recent publications

Cook AJ, Wellman RD, Nelson JC, Jackson LA, Tiwari RC. Group sequential method for observational data by using generalized estimating equations: application to Vaccine Safety Datalink. J R Stat Soc Ser C Appl Stat. 2015;64(2):319-38. doi: 10.1111/rssc.12075. Epub 2014 Sep 23.

Huang R, Moudon AV, Cook AJ, Drewnowski A. The spatial clustering of obesity: does the built environment matter? J Hum Nutr Diet. 2014 Oct 3. doi: 10.1111/jhn.12279. [Epub ahead of print]. PubMed

Cherkin DC, Sherman KJ, Balderson BH, Turner JA, Cook AJ, Stoelb B, Herman PM, Deyo RA, Hawkes RJ. Comparison of complementary and alternative medicine with conventional mind-body therapies for chronic back pain: protocol for the Mind-body Approaches to Pain (MAP) randomized controlled trial. Trials. 2014 Jun 7;15:211. doi: 10.1186/1745-6215-15-211. PubMed

Sherman KJ, Cook A, Wellman R, Kahn J, Cherkin D. Influence of the amount and duration of therapeutic massage for chronic neck pain on 12 and 26 week outcomes of pain and function. J Altern Complement Med. 2014;20(5):A49-50. doi: 10.1089/acm.2014.5129.abstract.

 

Research

urban setting apartments and skyscrapers obesity and the built environment

Built environment plays little role in weight gain

New research suggests fast food and other aspects of built environments don’t affect weight, contrary to earlier findings.

Vaccine Safety

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Biostatisticians track COVID-19 vaccine safety

Dr. Jennifer Nelson explains how KP scientists are helping the CDC and FDA keep an eye out for rare adverse events.

healthy findings blog

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Best weight-loss surgery for diabetes and severe obesity?

Watch video on latest results from PCORnet Bariatric Study. (Spoiler alert: Bypass, not sleeve.)