Andrea J. Cook, PhD

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“National interest in using data to improve patient care and safety is growing. Our group is developing the biostatistical methods for that work.”

Andrea J. Cook, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute

Andrea.J.Cook@kp.org
206-287-4257

Biography

Andrea Cook, PhD, is a biostatistician whose work focuses on leveraging available data such as electronic health records (EHRs) to efficiently address important public health questions and improve the overall health of our population. Dr. Cook has developed research methods using EHRs and other existing health care data for major initiatives led by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the U.S. Food and Drug Administration (FDA). Her work spans many areas, including hypertension control, cancer screening, obesity, diabetes, built environment, and alternative medicine for pain.

The goal of Dr. Cook’s research is finding interventions that improve patient care. She studies how pragmatic clinical trials, which are conducted under real-world conditions in health care organizations such as Kaiser Permanente Washington, can deliver more effective care and improve patient outcomes. Dr. Cook is a lead biostatistician for the Biostatistics and Study Design Core of the NIH Collaboratory, which facilitates the implementation of pragmatic clinical trials. She addresses the numerous statistical challenges of pragmatic clinical trials including how to design studies to answer research questions without impeding the delivery of care and how to use EHRs for more cost-effective studies.

Dr. Cook also studies how to use EHR data to improve the way we monitor the safety of new medical products including vaccines, drugs, and medical devices. She contributes to the FDA Sentinel Initiative and the CDC Vaccine Safety Datalink and has led the development of new statistical methods for actively monitoring medical products for rare adverse events using distributed data networks.

Dr. Cook obtained her PhD in biostatistics from the Harvard T.H. Chan School of Public Health in 2005. She is a member of the American Statistical Association and the Western North American Region of the International Biometric Society. She is also an affiliate professor in biostatistics at the University of Washington.

Research interests and experience

Recent publications

Nelson JC, Cook AJ, Yu O, Dominguez C, Zhao S, Greene SK, Fireman BH, Jacobsen SJ, Weintraub ES, Jackson LA. Challenges in the design and analysis of sequentially monitored postmarket safety surveillance evaluations using electronic observational health care data. Pharmacoepidemiol Drug Saf. 2012 Jan;21 Suppl 1:62-71. doi: 10.1002/pds.2324. PubMed

Cook AJ, Tiwari RC, Wellman RD, Heckbert SR, Li L, Heagerty P, Marsh T, Nelson JC. Statistical approaches to group sequential monitoring of postmarket safety surveillance data: current state of the art for use in the Mini-Sentinel pilot. Pharmacoepidemiol Drug Saf. 2012;21 Suppl 1:72-81. doi: 10.1002/pds.2320. PubMed

Fishman PA, Anderson ML, Cook AJ, Ralston JD, Catz SL, Carlson J, Larson EB, Green BB. Accuracy of blood pressure measurements reported in an electronic medical record during routine primary care visits. J Clin Hypertens. 2011;13(11):821-8. PubMed

Green B, Anderson M, Fishman P, Reid R, Catz S, McClure J, Cook A. Electronic health record-based cardiovascular risk assessment and the use of BMI when laboratory data is not available. Clin Med Res. 2011;9(3-4):151-152. PubMed

 

Research

urban setting apartments and skyscrapers obesity and the built environment

Built environment plays little role in weight gain

New research suggests fast food and other aspects of built environments don’t affect weight, contrary to earlier findings.

Vaccine Safety

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Biostatisticians track COVID-19 vaccine safety

Dr. Jennifer Nelson explains how KP scientists are helping the CDC and FDA keep an eye out for rare adverse events.

healthy findings blog

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Best weight-loss surgery for diabetes and severe obesity?

Watch video on latest results from PCORnet Bariatric Study. (Spoiler alert: Bypass, not sleeve.)