Andrea Cook, PhD, is a biostatistician whose work focuses on leveraging available data such as electronic health records (EHRs) to efficiently address important public health questions and improve the overall health of our population. Dr. Cook has developed research methods using EHRs and other existing health care data for major initiatives led by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the U.S. Food and Drug Administration (FDA). Her work spans many areas, including hypertension control, cancer screening, obesity, diabetes, built environment, and alternative medicine for pain.
The goal of Dr. Cook’s research is finding interventions that improve patient care. She studies how pragmatic clinical trials, which are conducted under real-world conditions in health care organizations such as Kaiser Permanente Washington, can deliver more effective care and improve patient outcomes. Dr. Cook is a lead biostatistician for the Biostatistics and Study Design Core of the NIH Collaboratory, which facilitates the implementation of pragmatic clinical trials. She addresses the numerous statistical challenges of pragmatic clinical trials including how to design studies to answer research questions without impeding the delivery of care and how to use EHRs for more cost-effective studies.
Dr. Cook also studies how to use EHR data to improve the way we monitor the safety of new medical products including vaccines, drugs, and medical devices. She contributes to the FDA Sentinel Initiative and the CDC Vaccine Safety Datalink and has led the development of new statistical methods for actively monitoring medical products for rare adverse events using distributed data networks.
Dr. Cook obtained her PhD in biostatistics from the Harvard T.H. Chan School of Public Health in 2005. She is a member of the American Statistical Association and the Western North American Region of the International Biometric Society. She is also an affiliate professor in biostatistics at the University of Washington.
Role of built environment; obesity prevention and control; nutrition
Analysis of longitudinal data; sequential methods
Physical activity; nutrition; built environment
Drewnowski A, Buszkiewicz J, Aggarwal A, Cook A, Moudon AV. A new method to visualize obesity prevalence in Seattle-King County at the census block level. Obes Sci Pract. 2017 Dec 28;4(1):14-19. doi: 10.1002/osp4.144. eCollection 2018 Feb. PubMed
Toh S, Rasmussen-Torvik LJ, Harmata EE, Pardee R, Saizan R, Malanga E, Sturtevant JL, Horgan CE, Anau J, Janning CD, Wellman RD, Coley RY, Cook AJ, Courcoulas AP, Coleman KJ, Williams NA, McTigue KM, Arterburn D, McClay J for the PCORnet Bariatric Study Collaborative. The national Patient-Centered Clinical Research Network (PCORnet) bariatric study cohort: rationale, methods, and baseline characteristics. JMIR Res Protoc. 2017 Dec 5;6(12):e222. doi: 10.2196/resprot.8323. PubMed
Green BB, Anderson ML, Cook AJ, Chubak J, Fuller S, Meenan RT, Vernon SW. A centralized mailed program with stepped increases of support increases time in compliance with colorectal cancer screening guidelines over 5 years: a randomized trial. Cancer. 2017 Nov 15;123(22):4472-4480. doi: 10.1002/cncr.30908. Epub 2017 Jul 28. PubMed
McClure JB, Blasi PR, Cook A, Bush T, Fishman P, Nelson J, Anderson ML, Catz SL. Corrigendum to "oral health 4 life: design and methods of a semi-pragmatic randomized trial to promote oral health care and smoking abstinence among tobacco quitline callers". Contemp Clin Trials. 57 (2017) 90-97. 2017 Jul 24. pii: S1551-7144(17)30469-X. doi: 10.1016/j.cct.2017.07.011. [Epub ahead of print]. No abstract available. PubMed
Dr. Jennifer Nelson explains how KP scientists are helping the CDC and FDA keep an eye out for rare adverse events.
Watch video on latest results from PCORnet Bariatric Study. (Spoiler alert: Bypass, not sleeve.)
Dr. David Arterburn and colleagues publish a large, long-term analysis of post-op safety of weight-loss surgeries.