Sascha Dublin, MD, PhD

Sascha Dublin

“My work helps people know what medications are safe, especially for vulnerable populations like pregnant women and older adults.”

Sascha Dublin, MD, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute
Physician, Washington Permanente Medical Group, Internal Medicine

Sascha.Dublin@kp.org
206-287-2870

Biography

Sascha Dublin, MD, PhD, is a general internist and epidemiologist who studies the health effects of prescription medications and other interventions using real-world health care data. Through her work, she aims to provide better information about the risks and benefits of different treatments so patients and doctors can make well-informed decisions.

Much of Dr. Dublin’s research focuses on the outcomes of medication use or other interventions during pregnancy. These studies take advantage of the rich clinical data available through electronic health records (EHRs). Some of her current work in this area includes:

  • comparing different treatments for hypertension in pregnancy, looking at both the safety and effectiveness of various medications;
  • working with the U.S. Food and Drug Administration (FDA) to study whether prescription opioid use in pregnancy increases the risk of birth defects; and
  • studying the impact of treating mild to moderate hypertension during pregnancy through an R01 grant from the National Institute of Child Health and Human Development.

Dr. Dublin recently led an impactful study with Kaiser Permanente Washington Health Research Institute colleagues exploring different methods to screen for diabetes in pregnancy. This work examined how outcomes changed for mothers and babies after Kaiser Permanente Washington made a big shift in their approach to gestational diabetes screening. This project found that a new, more intensive approach to screening did not improve health outcomes, and may have even worsened some. As a result, Kaiser Permanente Washington changed back to the previous, more widely used screening approach.

Beyond pregnancy, Dr. Dublin’s work includes studies of medication use and dementia risk in older adults. For example, her team found that heavy use of some commonly used medications including antihistamines increases dementia risk.  They also found that one widely used medication class, proton pump inhibitors, does not increase the risk of dementia—in contrast to some earlier reports—or fractures. 

Dr. Dublin has a strong interest in epidemiologic methods, particularly finding ways to better measure important variables. She has led methods workgroups for the FDA’s Sentinel Initiative and has experience using natural language processing and collecting data from patients through mobile phone apps. Dr. Dublin also has interest and expertise in improving the rigor and validity of observational studies by improving how they account for patients’ other illnesses and overall health status.

Dr. Dublin previously held a Paul B. Beeson Career Development Award (K23) from the National Institute on Aging. She sees patients one day a week in primary care at Kaiser Permanente Washington.

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Research interests and experience 

  • Aging & Geriatrics

    Medications and risk of cognitive decline; use of preventive medications; age-related disease and disability
  • Cardiovascular Health

    Epidemiology
  • Medication Use & Patient Safety

    Medication safety in vulnerable populations including older adults and pregnant women
  • Women’s Health

    Safety and effectiveness of interventions during pregnancy; medication use and safety during pregnancy
  • Child & Adolescent Health

    Impact of in utero medication exposure on the fetus or infant

Vaccines & Infectious Diseases

 

Recent publications

Leonard CE, Brensinger CM, Acton EK, Miano TA, Dawwas GK, Horn JR, Chung S, Bilker WB, Dublin S, Soprano SE, Phuong Pham Nguyen T, Manis MM, Oslin DW, Wiebe DJ, Hennessy S. Population-based signals of antidepressant drug interactions associated with unintentional traumatic injury. Clin Pharmacol Ther. 2021 Feb 9. doi: 10.1002/cpt.2195. Online ahead of print. PubMed

Dublin S, Walker R, Floyd JS, Shortreed SM, Fuller S, Albertson-Junkans L, Harrington LB, Greenwood-Hickman MA, Green BB, Psaty BM. Response to "ACE-2 downregulation and incidence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection". Am J Hypertens. 2020 Dec 15:hpaa212. doi: 10.1093/ajh/hpaa212. [Epub ahead of print]. PubMed

Wyner Z, Dublin S, Chambers C, Deval S, Herzig-Marx C, Rao S, Rauch A, Reynolds J, Brown JS, Martin D. The FDA MyStudies app: a reusable platform for distributed clinical trials and real-world evidence studies. JAMIA Open. 2020 Dec 11;3(4):500-505. doi: 10.1093/jamiaopen/ooaa061. eCollection 2020 Dec. PubMed

Badon SE, Dublin S, Nance N, Hedderson MM, Neugebauer R, Easterling T, Cheetham TC, Chen L, Holt VL, Avalos LA. Gestational weight gain and adverse pregnancy outcomes by pre-pregnancy bmi category in women with chronic hypertension: a cohort study. Pregnancy Hypertens. 2020 Oct 24;23:27-33. doi: 10.1016/j.preghy.2020.10.009. [Epub ahead of print]. PubMed

 

Drugs, diabetes, disparities

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Studying COVID-19 risk and outcomes

Dr. Sascha Dublin tells how studies of KP electronic health record data can improve COVID-19 treatment and prevention.

research

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Medication in pregnancy: Better data for healthier kids

Researchers need much bigger data sets to find outcomes that matter, Dr. Sascha Dublin and colleagues write in Pediatrics.

profile

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What inspires Sascha Dublin’s maternal health research?

Evidence from Dr. Dublin’s work helps patients and doctors make the best care choices in pregnancy.

KPWHRI In the Media

How Sascha Dublin is advancing maternal health research?

Hemoglobin A1C Screening in Early Gestational Diabetes

Clinical Lab Manager, Nov. 1, 2020