Sascha Dublin, MD, PhD, is a general internist and epidemiologist who studies the health effects of prescription medications and other interventions using real-world health care data. Through her work, she aims to provide better information about the risks and benefits of different treatments so patients and doctors can make well-informed decisions.
Much of Dr. Dublin’s research focuses on the outcomes of medication use or other interventions during pregnancy. These studies take advantage of the rich clinical data available through electronic health records (EHRs). Some of her current work in this area includes:
Dr. Dublin recently led an impactful study with Kaiser Permanente Washington Health Research Institute colleagues exploring different methods to screen for diabetes in pregnancy. This work examined how outcomes changed for mothers and babies after Kaiser Permanente Washington made a big shift in their approach to gestational diabetes screening. This project found that a new, more intensive approach to screening did not improve health outcomes, and may have even worsened some. As a result, Kaiser Permanente Washington changed back to the previous, more widely used screening approach.
Beyond pregnancy, Dr. Dublin’s work includes studies of medication use and dementia risk in older adults. For example, her team found that heavy use of some commonly used medications including antihistamines increases dementia risk. They also found that one widely used medication class, proton pump inhibitors, does not increase the risk of dementia—in contrast to some earlier reports—or fractures.
Dr. Dublin has a strong interest in epidemiologic methods, particularly finding ways to better measure important variables. She has led methods workgroups for the FDA’s Sentinel Initiative and has experience using natural language processing and collecting data from patients through mobile phone apps. Dr. Dublin also has interest and expertise in improving the rigor and validity of observational studies by improving how they account for patients’ other illnesses and overall health status.
Dr. Dublin previously held a Paul B. Beeson Career Development Award (K23) from the National Institute on Aging. She sees patients one day a week in primary care at Kaiser Permanente Washington.
Scherrer JF, Salas J, Floyd JS, Farr SA, Morley JE, Dublin S. Metformin and sulfonylurea use and risk of incident dementia. Mayo Clin Proc. 2019;94(8):1444-1456. doi: 10.1016/j.mayocp.2019.01.004. PubMed
Wartko PD, Weiss NS, Enquobahrie DA, Chan KCG, Stephenson-Famy A, Mueller BA, Dublin S. Antidepressant continuation in pregnancy and risk of gestational diabetes. Pharmacoepidemiol Drug Saf. 2019 Jul 12. doi: 10.1002/pds.4799. [Epub ahead of print]. PubMed
Scherrer JF, Morley JE, Salas J, Floyd JS, Farr SA, Dublin S. Association between metformin initiation and incident dementia among African American and White Veterans Health Administration patients. Ann Fam Med. 2019;17(4):352-362. doi: 10.1370/afm.2415. PubMed
Marcum ZA, Walker RL, Jones BL, Ramaprasan A, Gray SL, Dublin S, Crane PK, Larson EB. Patterns of antihypertensive and statin adherence prior to dementia: findings from the Adult Changes in Thought study. BMC Geriatr. 2019;19(1):41. doi: 10.1186/s12877-019-1058-6. PubMed
Nov. 7, 2018—In this short video, Dr. Sascha Dublin tells why KP is an ideal place to pursue her passion: Research to help vulnerable patients get the right drug treatment.
In Annals editorial Drs. Sascha Dublin and Michael Von Korff advocate more caution in prescribing these medications.
In our learning health system, we discovered that a new screening approach had increased diagnoses without improving overall outcomes. So remarkably, we switched back.
Opioid misuse and overdose are now a national priority. For decades, KPWHRI has worked to help patients find safe, effective ways to manage chronic pain.
Learn more about our work in opioid research.