Linda K. McEvoy, PhD

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“My research goals are to further our understanding of the wide variety of factors that influence cognitive and brain health in aging, to inform strategies to reduce risk of dementia.”

Linda K. McEvoy, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute

Biography

Linda K. McEvoy, PhD, is a senior investigator at Kaiser Permanente Washington Health Research Institute (KPWHRI) and professor emerita at the University of California (UC) San Diego. Dr. McEvoy uses epidemiological approaches to improve the understanding of cognitive and brain changes in typical aging and in neurodegenerative disorders such as Alzheimer’s disease. Her mission is to better understand the factors that may affect cognitive and brain health in aging, with the goal of informing strategies to maintain cognitive health and reduce dementia risk. These factors include genetic, health, behavioral, environmental, and psychosocial exposures across the life course.

Dr. McEvoy joined KPWHRI in 2023 to take over leadership of the ground-breaking Adult Changes in Thought (ACT) Study following the retirement of the study’s founder, Dr. Eric Larson. ACT is a large, longitudinal study of members of Kaiser Permanente Washington that began in1994 and has created a rich resource for the aging research community to examine factors that affect cognitive and brain health in aging.

In addition to her work on the ACT Study, Dr. McEvoy also performs research using data from the Women’s Health initiative, examining blood-based biomarkers of dementia risk, including epigenetic and proteomic measures.

Dr. McEvoy enjoys mentoring students, fellows, and junior faculty. At UC San Diego, she had leadership roles on several aging and Alzheimer’s disease training programs funded by the National Institutes of Health (NIH), and she taught courses in grant writing to junior faculty. She enjoys sharing her knowledge on the characteristics of successful grant applications, which she has accumulated through service on several NIH study sections.

Research interests and experience

Recent Publications

Nguyen S, Lu AT, Horvath S, Espeland MA, Rapp SR, Maihofer AX, Nievergelt CM, LaCroix AZ, McEvoy LK, Resnick SM, Beckman K, Shadyab AH Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study 2026 Mar;25(3):e70424. doi: 10.1111/acel.70424. PubMed

Shadyab AH, Zhang B, LaCroix AZ, McEvoy LK Randomization to hormone therapy and changes in plasma biomarkers of Alzheimer's pathology: The women's health initiative memory study 2026 Feb 11;207:108873. doi: 10.1016/j.maturitas.2026.108873. Epub 2026-02-11. PubMed

Gray SL, Yu O, Gatto NM, Marcum ZA, Latimer CS, Postupna N, Su YR, Barthold D, van Dalen JW, Richard E, Keene CD, Shaw PA, McEvoy LK, Larson EB, Crane PK Angiotensin II-Stimulating Antihypertensive Medications and Dementia-Related Neuropathology 2026 Feb 2;9(2):e2559113. doi: 10.1001/jamanetworkopen.2025.59113. Epub 2026-02-02. PubMed

McEvoy LK, Zhang B, Nguyen S, Maihofer AX, Nievergelt CM, Casanova R, Horvath S, Lu AT, Davatzikos C, Erus G, Resnick SM, Espeland MA, Rapp SR, Beckman K, Ferrucci L, Lacroix AZ, Shadyab AH Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration 2026 Jan 26 doi: 10.64898/2026.01.23.26344650. Epub 2026-01-26. PubMed

Zhang B, McEvoy LK, Nguyen S, Espeland MA, Rapp SR, Horvath S, Lu AT, LaCroix AZ, Nievergelt CM, Maihofer AX, Resnick SM, Mielke MM, Beckman K, Li D, Silver B, Manson JE, Ferrucci L, Shadyab AH Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease 2025 Dec;21(12):e70983. doi: 10.1002/alz.70983. PubMed

 

Research

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Blood test predicts dementia in women years before symptoms begin

Study finds biomarker p-tau217 strongly linked to future dementia risk.

Research

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Autopsy study links BP drugs to possible brain benefits

Research supports theory that some blood pressure medications may provide extra protection against dementia.

Research

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Can preventing hearing loss reduce dementia risk?

New research from Linda McEvoy, PhD, helps explain how hearing loss affects the brain.