Gregory E. Simon, MD, MPH
“We bring a practical approach to mental health research, working to break down barriers between research and real-world health care.”
Gregory E. Simon, MD, MPH
Senior Investigator, Kaiser Permanente Washington Health Research Institute
Psychiatrist, Washington Permanente Medical Group
Professor, Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine
Research Professor, Psychiatry and Behavioral Sciences, University of Washington
Biography
Greg Simon, MD, MPH, is a psychiatrist and senior investigator well-known for his extensive research on practical approaches to improving mental health care. He seeks to develop and evaluate effective real-world strategies that support better mental health and wellness. Current areas of emphasis include identifying and assessing suicide risk, improving care for treatment-resistant depression, and reducing racial and ethnic disparities in mental health care.
Dr. Simon leads the Mental Health Research Network (MHRN), a consortium of research centers affiliated with 13 large health systems across the United States, including Kaiser Permanente Washington. This network, originally funded through a cooperative agreement with the National Institute of Mental Health, aims to improve the efficiency, relevance, and impact of mental health clinical and health services research. The MHRN is exploring a broad range of issues—including suicide prevention, improving heart health in people with serious mental illness, using electronic medical records to improve follow-up care for depression, and understanding the causes of racial and ethnic disparities in mental health care.
Dr. Simon and his MHRN colleagues have conducted several large studies across MHRN health systems, including:
- A pragmatic trial in four health systems examining the effect of systematic outreach programs to prevent suicide attempt among people at high risk.
- Using electronic health records from seven health systems to develop and validate machine learning models to identify people at high risk of suicidal behavior.
- A pragmatic trial in two health systems evaluating electronic health record tools to reduce risk of cardiovascular disease in people with bipolar disorder and schizophrenia.
- A rigorous evaluation of Zero Suicide care improvement programs in six health systems
- Developing measures to assess quality of care for depression in two health systems.
Dr. Simon sits on the editorial board for the journal General Hospital Psychiatry, and co-chairs the National Academy of Medicine’s Forum on Drug Discovery, Development and Translation.. Dr. Simon has practiced adult psychiatry in Kaiser Permanente Washington's Mental Health and Wellness Service since 1990. He is also a professor in the department of Health Systems Science at the Bernard J Tyson Kaiser Permanente School of Medicine and an adjunct professor inPsychiatry and Behavioral Dciences at the University of Washington.
Research interests and experience
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Mental Health
Depression; bipolar disorder; suicide prevention; self-management; treatment adherence
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Chronic Illness Management
Comorbidity of mental health conditions with obesity, diabetes, heart disease, and substance use disorders.
Recent publications
Whiteside U, Lungu A, Richards J, Simon GE, Clingan S, Siler J, Snyder L, Ludman E. Designing messaging to engage patients in an online suicide prevention intervention: survey results from patients with current suicidal ideation. J Med Internet Res. 2014 Feb 7;16(2):e42. doi: 10.2196/jmir.3173. PubMed
Lu CY, Zhang F, Lakoma MD, Madden JM, Rusinak D, Penfold RB, Simon G, Ahmedani BK, Clarke G, Hunkeler EM, Waitzfelder B, Owen-Smith A, Raebel MA, Rossom R, Coleman KJ, Copeland LA, Soumerai SB. Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study. BMJ. 2014 Jun 18;348:g3596. doi: 10.1136/bmj.g3596. PubMed
Simon GE, Rutter CM, Peterson D, Oliver M, Whiteside U, Operskalski B, Ludman EJ. Does response on the PHQ-9 depression questionnaire predict subsequent suicide attempt or suicide death? Psychiatr Serv. 2013 Dec 1;64(12):1195-202. doi: 10.1176/appi.ps.201200587. Epub 2013 Sep 16. PubMed
Richesson RL, Hammond WE, Nahm M, Wixted D, Simon GE, Robinson JG, Bauck AE, Cifelli D, Smerek MM, Dickerson J, Laws RL, Madigan RA, Rusincovitch SA, Kluchar C, Califf RM. Electronic health records based phenotyping in next-generation clinical trials: a perspective from the NIH Health Care Systems Collaboratory. J Am Med Inform Assoc. 2013 Dec;20(e2):e226-31. doi: 10.1136/amiajnl-2013-001926. Epub 2013 Aug 16. PubMed
Penfold RB, Stewart C, Hunkeler EM, Madden JM, Cummings JR, Owen-Smith AA, Rossom RC, Lu CY, Lynch FL, Waitzfelder BE, Coleman KA, Ahmedani BK, Beck AL, Zeber JE, Simon GE. Use of antipsychotic medications in pediatric populations: what do the data say? Curr Psychiatry Rep. 2013 Dec;15(12):426. doi: 10.1007/s11920-013-0426-8. PubMed
Fortney JC, Pyne JM, Simon GE, Ludman EJ. Response to White. Am J Psychiatry. 2013;170(8):926-7. doi: 10.1176/appi.ajp.2013.13040471r. PubMed
Simon GE, Peterson D, Hubbard R. Is treatment adherence consistent across time, across different treatments and across diagnoses? Gen Hosp Psychiatry. 2013 Mar-Apr;35(2):195-201. doi: 10.1016/j.genhosppsych.2012.10.001. Epub 2012 Nov 9. PubMed
Simon GE, Ludman EJ. Should mental health interventions be locally grown or factory-farmed? Am J Psychiatry. 2013 Apr 1;170(4):362-5. doi: 10.1176/appi.ajp.2013.13010043. PubMed
Simon GE. Benefits and costs of improving depression treatment in people with heart disease: comment on "Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression." JAMA Intern Med. 2013 Jun 10;173(11):1004-5. doi: 10.1001/jamainternmed.2013.925. PubMed
Ding VY, Hubbard RA, Rutter CM, Simon GE. Assessing the accuracy of profiling methods for identifying top providers: performance of mental health care providers. Health Serv Outcomes Res Methodol. 2013;13(1):1-17. Epub 2012 Sep 18. PubMed
Research
Researchers have a proven prescription for reducing suicide rates
In a new multistate study, the Zero Suicide Model reduced suicide rates by 25%.
Research
Suicide attempts decreased after adding suicide care to primary care
Safety planning and risk screening improved outcomes for adult patients.
Research
Can machine learning help treat depression more effectively?
A new grant funds modeling work to make personalized treatment possible.
Research
Understanding adoption of Lock to Live, a decision aid supporting suicide prevention
KPWHRI research finds ways to increase use of a firearm safety tool.
Research
A medication that can relieve symptoms of psychosis is underused
Study finds that many patients who might benefit from clozapine don’t receive it.
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