Greg Simon, MD, MPH, is a psychiatrist and senior investigator well-known for his extensive research on practical approaches to improving mental health care. He seeks to develop and evaluate effective real-world strategies that support better mental health and wellness. Current areas of emphasis include identifying and assessing suicide risk, improving care for treatment-resistant depression, and early intervention for mental health conditions in children and youth.
Dr. Simon leads the Mental Health Research Network (MHRN), a consortium of research centers affiliated with 13 large health systems across the United States, including Kaiser Permanente Washington. This network, funded through a cooperative agreement with the National Institute of Mental Health, aims to improve the efficiency, relevance, and impact of mental health clinical and health services research. Now in its second five-year funding cycle, the MHRN is exploring a broad range of issues—including suicide prevention, improving heart health in people with serious mental illness, using electronic medical records to improve follow-up care for depression, and understanding the causes of racial and ethnic disparities in mental health care.
Dr. Simon and his MHRN colleagues are conducting several large studies across MHRN health systems, including:
Dr. Simon is an editor for the Cochrane Collaboration’s depression and anxiety review group, sits on the editorial board for General Hospital Psychiatry, and serves on the advisory board for the National Institutes of Health’s All of Us Program (formerly Precision Medicine Initiative). Earlier, he served on the editorial boards of Psychiatric Services and Psychological Medicine and chaired the scientific advisory board for the Depression and Bipolar Support Alliance. Dr. Simon has practiced adult psychiatry in Kaiser Permanente Washington's Mental Health and Wellness Service since 1990 and is a research professor in psychiatry and behavioral sciences at the University of Washington.
Balestrieri M, Sisti D, Rocchi M, Rucci P, Simon G, Araya R, de Girolamo G. Effectiveness of clinical decision support systems and telemedicine on outcomes of depression: a cluster randomized trial in general practice. Fam Pract. 2020 Aug 7:cmaa077. doi: 10.1093/fampra/cmaa077. Online ahead of print. PubMed
Yarborough BJH, Stumbo SP, Ahmedani B, Rossom R, Coleman K, Boggs JM, Simon GE. Suicide behavior following PHQ-9 screening among individuals with substance use disorders. J Addict Med. 2020 Jul 10. doi: 10.1097/ADM.0000000000000696. [Epub ahead of print]. PubMed
Yang SW, Kernic MA, Mueller BA, Simon GE, Chan KCG, Vander Stoep A. Association of Parental Mental Illness With Child Injury Occurrence, Hospitalization, and Death During Early Childhood. JAMA Pediatr. 2020 Jun 22:e201749. doi: 10.1001/jamapediatrics.2020.1749 [Epub ahead of print] PubMed
Gliklich RE, Leavy MB, Cosgrove L, Simon GE, Gaynes BN, Peterson LE, Olin B, Cole C, DePaulo JR Jr, Wang P, Crowe CM, Cusin C, Nix M, Berliner E, Trivedi MH. Harmonized outcome measures for use in depression patient registries and clinical practice. Ann Intern Med. 2020 Jun 16;172(12):803-809. doi: 10.7326/M19-3818. Epub 2020 May 12. PubMed
Coley RY, Boggs JM, Simon GE. Measuring outcome of depression: it is complicated. Psychiatr Serv. 2020;71(5):528. doi: 10.1176/appi.ps.71502. PubMed
Simon GE, Platt R, Hernandez AF. Evidence from pragmatic trials during routine care - slouching toward a learning health system. N Engl J Med. 2020;382(16):1488-1491. doi: 10.1056/NEJMp1915448. PubMed
Shortreed SM, Simon GE. Using predictive analytics to improve pragmatic trial design. Clin Trials. 2020 Aug;17(4):394-401. doi: 10.1177/1740774520910367. Epub 2020 Mar 10. PubMed
Richards JE, Shortreed SM, Simon GE, Penfold RB, Glass JE, Ziebell R, Williams EC. Association between patterns of alcohol use and short-term risk of suicide attempt among patients with and without reported suicidal ideation. J Addict Med. 2020 Mar 5. doi: 10.1097/ADM.0000000000000637. [Epub ahead of print]. PubMed
Lynch FL, Peterson EL, Lu CY, Hu Y, Rossom RC, Waitzfelder BE, Owen-Smith AA, Hubley S, Prabhakar D, Keoki Williams L, Beck A, Simon GE, Ahmedani BK. Substance use disorders and risk of suicide in a general US population: a case control study. Addict Sci Clin Pract. 2020 Feb 21;15(1):14. doi: 10.1186/s13722-020-0181-1. PubMed
Owen-Smith A, Stewart C, Sesay MM, Strasser SM, Yarborough BJ, Ahmedani B, Miller-Matero LR, Waring SC, Haller IV, Waitzfelder BE, Sterling SA, Campbell CI, Hechter RC, Zeber JE, Copeland LA, Scherrer JF, Rossom R, Simon G. Chronic pain diagnoses and opioid dispensings among insured individuals with serious mental illness. BMC Psychiatry. 2020 Jan 31;20(1):40. doi: 10.1186/s12888-020-2456-1. PubMed
Findings provide roadmap for addressing barriers and improving suicide prevention.
Kaiser Permanente physician-scientist will receive American Foundation for Suicide Prevention's Lifesavers Research Award.
How new processes improved suicide risk identification when mental health visits went virtual.
In predicting disease, some mathematical models are more reliable than others. Dr. Greg Simon explains why.
Medscape, Feb. 12, 2021