Greg Simon, MD, MPH, is a psychiatrist and senior investigator well-known for his extensive research on practical approaches to improving mental health care. He seeks to develop and evaluate effective real-world strategies that support better mental health and wellness. Current areas of emphasis include identifying and assessing suicide risk, improving care for treatment-resistant depression, and early intervention for mental health conditions in children and youth.
Dr. Simon leads the Mental Health Research Network (MHRN), a consortium of research centers affiliated with 13 large health systems across the United States, including Kaiser Permanente Washington. This network, funded through a cooperative agreement with the National Institute of Mental Health, aims to improve the efficiency, relevance, and impact of mental health clinical and health services research. Now in its second five-year funding cycle, the MHRN is exploring a broad range of issues—including suicide prevention, improving heart health in people with serious mental illness, using electronic medical records to improve follow-up care for depression, and understanding the causes of racial and ethnic disparities in mental health care.
Dr. Simon and his MHRN colleagues are conducting several large studies across MHRN health systems, including:
Dr. Simon is an editor for the Cochrane Collaboration’s depression and anxiety review group, sits on the editorial board for General Hospital Psychiatry, and serves on the advisory board for the National Institutes of Health’s All of Us Program (formerly Precision Medicine Initiative). Earlier, he served on the editorial boards of Psychiatric Services and Psychological Medicine and chaired the scientific advisory board for the Depression and Bipolar Support Alliance. Dr. Simon has practiced adult psychiatry in Kaiser Permanente Washington's Mental Health and Wellness Service since 1990 and is a research professor in psychiatry and behavioral sciences at the University of Washington.
Yeh HH, Westphal J, Hu Y, Peterson EL, Williams LK, Prabhakar D, Frank C, Autio K, Elsiss F, Simon GE, Beck A, Lynch FL, Rossom RC, Lu CY, Owen-Smith AA, Waitzfelder BE, Ahmedani BK. Diagnosed mental health conditions and risk of suicide mortality. Psychiatr Serv. 2019 Sep 1;70(9):750-757. doi: 10.1176/appi.ps.201800346. Epub 2019 Jun 12. PubMed
Simon GE. Why the Nails Should Boss the Hammers. Psychiatr Serv. 2019 Aug 1;70(8):642-643. doi: 10.1176/appi.ps.201900218. Epub 2019 May 29. PubMed
Yarborough BJH, Ahmedani BK, Boggs JM, Beck A, Coleman KJ, Sterling S, Schoenbaum M, Goldstein-Grumet J, Simon GE. Challenges of population-based measurement of suicide prevention activities across multiple health systems. eGEMS (Wash DC). 2019;7(1):13. doi: 10.5334/egems.277. PubMed
Stewart CC, Lu CY, Yoon TK, Coleman KJ, Crawford PM, Lakoma MD, Simon GE. Impact of ICD-10-CM transition on mental health diagnoses recording. eGEMS (Wash DC). 2019;7(1):14. doi: 10.5334/egems.281. PubMed
Jones SMW, Crane PK, Simon G. A comparison of individual change using item response theory and sum scoring on the Patient Health Questionnaire-9. Ann Depress Anxiety. 2019; 6(1): 1098.
Simon GE, Shortreed SM, Coley RY, Penfold RB, Rossom RC, Waitzfelder BE, Sanchez K, Lynch FL. Assessing and minimizing re-identification risk in research data derived from health care records. eGEMS (Wash DC). 2019;7(1):6. doi: 10.5334/egems.270. PubMed
Shortreed SM, Rutter CM, Cook AJ, Simon GE. Improving pragmatic clinical trial design using real-world data. Clin Trials. 2019 Jun;16(3):273-282. doi: 10.1177/1740774519833679. Epub 2019 Mar 13. PubMed
Simon GE. Big data from health records in mental health care: hardly clairvoyant but already useful. JAMA Psychiatry. 2019 Apr 1;76(4):349-350. doi: 10.1001/jamapsychiatry.2018.4510. PubMed
Gong J, Simon GE, Liu S. Machine learning discovery of longitudinal patterns of depression and suicidal ideation. PLoS One. 2019 Sep 20;14(9):e0222665. doi: 10.1371/journal.pone.0222665. eCollection 2019. PubMed
Simon GE, Richesson R, Weinfurt K, Hernandez AF, Curtis LH. Statistical code for clinical research papers. Ann Intern Med. 2019;170(1):80. doi: 10.7326/L18-0613. PubMed
Findings provide roadmap for addressing barriers and improving suicide prevention.
Kaiser Permanente physician-scientist will receive American Foundation for Suicide Prevention's Lifesavers Research Award.
How new processes improved suicide risk identification when mental health visits went virtual.
In predicting disease, some mathematical models are more reliable than others. Dr. Greg Simon explains why.
Medscape, Feb. 12, 2021