september 2019

KPWHRI recently received word of 4 new awards.

CalFresh Evaluation

A five-month, $89,365 grant from Kaiser Foundation Health Plan. Major goals: To evaluate the Kaiser Permanentee Community Health CalFresh enrollment initiative that will target Kaiser Permanente members who are not enrolled but likely eligible for CalFresh food stamp benefits and connect them to enrollment assistance offered by organizations seeking to streamline the application process. The principal investigator is Allen Cheadle.

Hypoglycemia Focus Groups

A three-month, $16,880 grant from the Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To hold focus groups with patients who have type 2 diabetes and have experience with hypoglycemia to inform design of a PCORI resubmission. The principal investigator is James D. Ralston

Kaiser Permanente National Social Needs Survey

A two-year, $1,224,876 grant from Kaiser Permanente Community Benefit. Major goals: To conduct a Kaiser Permanente national social needs survey that endeavors characterize the prevalence of social needs of a nationally representative sample of Kaiser Permanente members, identify subpopulations of Kaiser Permanente members who are at high risk for social needs using predictive modeling. The project also will seek to compare members with social needs to their unafflicted counterparts on cost, utilization, and clinical metrics., and create a social risk adjustment score for our members. The principal investigator is Cara C. Lewis

National Institutes of Aging (NIA) Alzheimer’s Disease / Alzheimer’s Disease Related Dementias (AD/ADRD) Health Care Systems Research Collaboratory

A five-year, $1,571,490 grant from National Institute on Aging (NIA). Major goals: To work with the coordinating center at Brown University to develop a program to assist the Collaboratory participants along with partners in NIA in issues related to interactions with health care systems that are research sites for pragmatic trials.  We will also convene leaders to oversee our work and coordinate it. In addition, we will seek generalizable knowledge based on experience in planning and implementing trials as well as implementing results of trials into systems using the model of Learning Health Systems. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson


august 2019

KPWHRI recently received word of 18 new awards.

Determining the Optimal Duration of Buprenorphine Treatment to Reduce the Risk of Relapse, Overdose, and Mortality

A one-year, $8,800 grant from National Institute on Drug Abuse. Major goals: To assess how different lengths of buprenorphine retention are related to mortality among patients who have initiated buprenorphine treatment for opioid use disorder. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise M. Boudreau.

Developing a Prescription Opioid Registry across Diverse Health Systems

A one-year, $4,797 grant from National Institute on Drug Abuse. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise M. Boudreau.

Heart Failure

A one-year, $561,743 grant from AMGEN. The principal investigator is Jessica Chubak.

Predicting Self-Harm, Suicide Attempt, and Suicidal Death Using Longitudinal Electronic Health Records (EHR), Claims and Mortality Data

A four-year, $300,986 grant from National Institute of Mental Health. Major goals: To develop and validate novel methods for identifying suicide risk factors (emotional state, life stressors, ideation) in unstructured clinical text (e.g., encounter notes, progress notes, discharge summaries) on patients who were admitted to the emergency department (ED) or hospitalized for psychiatric conditions using machine learning techniques. We will develop machine learning algorithms to predict self-harm, suicide attempts, or suicidal deaths after an ED admission or hospitalization using demographics, clinical characteristics, physical and social health, medication and treatment, and history of emotional valence and life stressors in the 6 months prior to and during the index ED admission or hospitalization. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold.

Rainier Valley Community Clinic Birth Bundle Project

A one-year, $19,690 grant from South Seattle Women's Health Foundation. Major goals: Rainier Valley Community Clinic (RVCC) has asked for an evaluation proposal from the Center for Community Health and Evaluation (CCHE) to conduct evaluation of the Birth Bundle Project (BBP) between April 1, 2019-December 31, 2020.   For this project, CCHE proposes a mixed-methods evaluation, including the activities outlined in the table below. The evaluation will seek to answer the following questions: 1) Are providers being trained systematically and successfully to do this work? 2) Is BBP enrolling families successfully? 3) Are outcomes improving for BBP clients (pre-term delivery, breastfeeding initiation and sustaining, etc.) 4. What are barriers/challenges/successes/lessons learned from implementing BBP? The principal investigator is Elena S. Kuo.

Seattle Flu Study

A seven-month, $29,640 grant from Bill and Melinda Gates Foundation. Major goals: The overall goal of the Seattle Flu Study is to assess the short-term evolution of influenza viruses within a defined geographic area through high-volume specimen collection. The study will be enrolling subjects from daycare centers, homeless shelters, international arrivals at SeaTac, outpatient clinics, and the general public. KPWA's roles are the following: 1) Provide residual specimens from our enrollment in the US Flu VE Network Study; 2) Help design a vaccine effectiveness study using Seattle Flu Study data. The Kaiser Permanente Washington Health Research Institute lead investigator is Michael L. Jackson.

Sentinel Data Partner (DP) Year 6 Infrastructure: Activities 1 – 10

A one-year, $313,316 grant from Food and Drug Administration. Major goals: To update and add to the Sentinel Common Data Model, harmonize and characterize processes initiated on the pool of existing clinical data elements, analyze and characterize existing clinical data elements to inform best use of these data for Sentinel, and run queries on questions related to drug safety. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise M. Boudreau.

The Michigan Sustained Patient-Centered Alcohol-Related Care (MI-SPARC) Trial

A three-year, $2,268,767 grant from Agency for Healthcare Research and Quality. Major goals: This pragmatic trial in 125 primary care clinics will use evidence-based strategies to implement evidence-based clinical care for unhealthy alcohol use, including alcohol screening, brief counseling to prevent harm due to drinking, and evidence-based treatments for alcohol use disorders. The principal investigator is Katharine A. Bradley.

U.S. Deprescribing Research Network

A five-year, $540,121 grant from National Institute on Aging. Major goals: TBD. The Kaiser Permanente Washington Health Research Institute lead investigator is Sascha Dublin.

 


july 2019

KPWHRI recently received word of 10 new awards.

Alzheimer’s Disease Related Neuropathology Among Patients with Medication Treated Type 2 Diabetes in a Community-Based Autopsy Cohort

A one-year, $29,711 grant from National Institute on Aging. Major goals: To examine dementia-related neuropathology in autopsied brains of individuals who used Type 2 Diabetes (T2DM) medications prior to death, thus offering novel findings that increase understanding of the relationship between Alzheimer’s Disease (AD) and long-term exposure to these drugs. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.

Antihypertensives and the Aging Brain

A three-year, $308,545 grant from National Institute on Aging. Major goals: To better understand the effects of different types of antihypertensive drugs on the aging brain including information about optimal levels of blood pressure control. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.

CAFÉ: Clinic-based Intervention to Address Financial Hardship for People with Cancer

A five-year, $3,732,201 grant from National Cancer Institute. Major goals: In our previously Robert Wood Johnson Foundation (RWJF)-funded research, we conducted a human-centered design study that resulted in a comprehensive, team-based model for clinical teams to invite and address all types of cost questions and concerns from patients. We now propose a multi-site randomized trial in which we will implement and test this comprehensive financial experience intervention among people diagnosed with cancer. The principal investigator is Nora Henrikson.

Development of a Mobile Health (mHealth) Intervention for Ambivalent Smokers: A Pilot Feasibility Study

A two-year, $420,223 grant from National Cancer Institute. Major goals: To assess the feasibility, acceptability, and potential efficacy of a scalable mobile health intervention for socioeconomically disadvantaged smokers who are ambivalent about quitting smoking. The principal investigator is Jennifer B. McClure.

Dignified Journeys

A one-year, $193,785 grant from Kaiser Permanente Washington. Major goals: To design and evaluate the delivery system’s “Dignified Journeys” program. The principal investigator is Robert Penfold.

Impact of Opioid Medication Management on Patient Outcomes

A six-month, $34,927 grant from Kaiser Permanente Washington Health Research Institute Development Fund. The principal investigator is Michael L. Parchman.

Integration of Firearm Suicide Prevention Tools in Health Care Settings: Patient-Reported Access to Firearms & Decision Support for Securing Firearms

A six-month, $113,939 grant from Kaiser Permanente. Major goals: To explore the relationship between responses to the screening questions and subsequent firearm injury events using electronic health record data, complemented by interview data collected prospectively from patients assessing the acceptability of the firearm access question. In parallel, the study will integrate access to a web-based decision aid for safe firearm storage the screening workflow for clinicians who are seeing patients at risk for suicide. The study will examine the utility of this new decision aid for clinicians and the extent to which the aid is used by patients. The principal investigator is Julie E. Richards.

Patient Shared Savings - Simulation Completion

A seven-month, $9,410 grant from Kaiser Permanente Washington Health Research Institute Directors Project Resource Fund. The principal investigator is Kai Yeung.

Self-Testing Options in the Era of Primary Human Papillomavirus (HPV) Screening for Cervical Cancer: the STEP Trial

A five-year, $3,493,227 grant from National Cancer Institute. Major goals: The Self-Testing options in the Era of Primary HPV screening for cervical cancer (STEP) is a pragmatic randomized trial that will evaluate effectiveness of home-based human papillomavirus (HPV) kits for improving cervical cancer screening uptake, cost-effectiveness, and patient and provider experience. The principal investigator is Diana S. Buist.

Value-based Formulary-Essentials: Testing and Expanding on Value in Prescription Drug Benefit Design

A two-year, $399,917 grant from the Donaghue Foundation. Major goals: To improve value in pharmaceutical care by testing a promising drug formulary that aligns patient out-of-pocket costs for drugs with the drugs’ estimated value. We aim to evaluate the impact of this formulary on (1) medication use, stratifying based on whether cost-sharing for a drug increased or did not change with Value-Based Formulary-Essentials; (2) spending by patients and by plan for drugs and non-drug medical care; and (3) emergency department use, hospitalizations and outpatient office visits. The principal investigator is Kai Yeung.


june 2019

KPWHRI recently received word of 5 new awards.

Pathways from Chronic Prescription Opioid Use to New Onset Mood Disorder

A five-year, $124,469 grant from National Institute on Drug Abuse. Major goals: Past studies by members of this research team found that longer term (>90 day) use of opioids was associated with increased risk for depression as well as attenuated response to depression treatment and reduced rates of recovery. This prospective cohort study proposes collecting data from 1,500 patients using prescription opioids to determine the risk factors, (e.g. lifetime history of depression, substance use disorder, poor functioning), that may increase risk of opioid analgesic use (OAU) related depression. We plan to characterize the type of depression most strongly associated with OAU and determine depression subtypes associated with incident opioid misuse and abuse. Study results could help clinicians educate patients and provide evidence to further encourage pain patients to limit OAU as much as possible to improve their mood and quality of life. The Kaiser Permanente Washington Health Research Institute lead investigator is Lynn DeBar.

Shared Decision Making for Bariatric Surgery in Patients with Severe Obesity

A three-year, $2,091,540 grant from Patient-Centered Outcomes Research Institute. Major goals: To refine, deploy, and rigorously evaluate a multicomponent strategy to implement our shared decision-making approach to improve bariatric surgery decisions among patients with severe obesity in primary care and specialty care settings. The principal investigator is David E. Arterburn.

Cancer Research Network Catalyst Proposal

A three-month, $2,146 grant from National Cancer Institute. Major goals: To support development of an R01 grant application to develop a risk stratification model to identify patients at high risk for chemotherapy associated peripheral neuropathy. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

Finding Pregnancy Discussion in Electronic Health Record Notes

A three-month, $3,858 grant from Kaiser Permanente Washington Health Research Institute Directors Project Resource Fund. Major goals: Explore documentation of discussions about pregnancy intent and contraception status in reproductive age women receiving first prescription of antihypertensive medications. The principal investigator is Lu Chen.

Targeted Safety Study for Shingrix in the United States (EPI-ZOSTER-030 VS)

A one-year, $26,011 grant from GlaxoSmithKline. Major goals: To assess the risk of new-onset gout, new-onset polymyalgia rheumatica, new-onset temporal arteritis (also known as Giant Cell Arteritis), and new-onset Guillain Barré syndrome following vaccination with Shingrix. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer C. Nelson.


MAY 2019

KPWHRI recently received word of 9 new awards.

Advancing Methods for Using Electronic Health Record Data to Study Unanticipated Adverse Effects of Prescription Opioid Use

A nine-month, $50,000 grant from KPWHRI Development Fund. Major goals: To prepare and submit for publication at least two manuscripts addressing important methodological challenges encountered by the Study 1B project team. The principal investigator is David S. Carrell.

Cancer Research Network (CRN) Catalyst Proposal

A three-month, $2,146 grant from National Cancer Institute. Major goals: To support development of an R01 grant application to develop a risk stratification model to identify patients at high risk for chemotherapy associated peripheral neuropathy. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

Digital Treatments for Substance Use Disorder (DIGITS) in Primary Care: A Hybrid Type-III Implementation Trial

A five-year, $3,946,350 grant from National Institute on Drug Abuse. Major goals: To evaluate strategies for increasing the adoption and penetration of digital health tools for substance use disorders in primary care. The principal investigator is Joseph E. Glass.

Finding Pregnancy Discussion in Electronic Health Record Notes

A three-month, $3,858 grant from Kaiser Permanente Washington Health Research Institute Directors Project Resource Fund. Major goals: Explore documentation of discussions about pregnancy intent and contraception status in reproductive age women receiving first prescription of antihypertensive medications. The principal investigator is Lu Chen.

Honoring What Matters Most to Patients with Multiple Chronic Conditions: Feasibility Study

A three-month, $24,405 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To test the feasibility and acceptability of using the tool for eliciting and using personal values to guide care in a pilot study of patients with Multiple Chronic Conditions (MCC) in primary care. The principal investigator is James D. Ralston.

Kaiser Permanente Mid-Atlantic States (KP MAS) - Safety Net Strategy

A three-month, $13,000 grant from Kaiser Foundation Hospitals – Mid-Atlantic States Region. Major goals: To provide strategic planning and facilitation support to KP MAS Community Health to develop its safety net strategy. The principal investigator is Maggie Jones.

North Central Accountable Community of Health - Evaluation Design – 2019

A six-month, $25,000 grant from North Central Accountable Community of Health. Major goals: This project will design an evaluation for the North Central Accountable Community of Health Medicaid Transformation Projects. The principal investigator is Allen Cheadle.

Sentinel Operations Center Learning Phenotype Laboratory – Phase 2

A one-year, $769,489 grant from Food and Drug Administration. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer C. Nelson.

The Electronic Medical Records and Genomics (eMERGE) Network, Phase III

A one-year, $707,923 grant from National Human Genome Research Institute. Major goals: To build on the previous findings of the eMERGE parent grant. This includes expanding the understanding of penetrance and the impact a variant has on clinical outcomes, developing a natural language processing component for five high-priority phenotypes, and exploring the challenges involved in identifying at-risk family members. The principal investigator is Eric B. Larson.


April 2019

KPWHRI recently received word of 6 new awards.

Chronic Obstructive Pulmonary Disease (COPD), Asthma, And Respiratory Disease Effectiveness (CARE) For 21st Century Cures:  Perform Feasibility Assessments for Subsequent COPD and Asthma Comparative Effectiveness Studies

A nine-month, $16,000 grant from Food and Drug Administration. Major goals: This Scope of Work pertains to the feasibility activity for “COPD, Asthma, and Respiratory Disease Effectiveness (CARE) for 21st Century Cures”, a series of descriptive and comparative effectiveness studies on medications important to the management of obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and asthma. In this activity, we will conduct the descriptive analyses to evaluate feasibility and to provide a framework for subsequent effectiveness studies in COPD and asthma patient cohorts that will include exploration of cohort definitions, medication utilization, and effectiveness outcomes. All definitions will be feasible to implement using data formatted to the Sentinel Common Data Model (SCDM) and the Cohort Identification and Descriptive Analysis tool Level 1+ Modular Programs. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise M. Boudreau.

Cancer Research Network (CRN) Catalyst Proposal

A three-month, $2,146 grant from National Cancer Institute. Major goals: To support development of an R01 grant application to develop a risk stratification model to identify patients at high risk for chemotherapy associated peripheral neuropathy. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

Finding Pregnancy Discussion in Electronic Health Record (EHR) Notes

A three-month, $3,858 grant from Kaiser Permanente Washington Health Research Institute Directors Project Resource Fund. Major goals: Explore documentation of discussions about pregnancy intent and contraception status in reproductive age women receiving first prescription of antihypertensive medications. The Kaiser Permanente Washington Health Research Institute lead investigator is Lu Chen.

Improving Confounder Control in Electronic Health Record (EHR)-Based Studies of Cancer Epidemiology

A two-year, $90,085 grant from National Cancer Institute. Major goals: To develop novel statistical methods to eliminate bias; and to determine sensitivity of results to violations of assumptions about missing data patterns to improve the validity of research using electronic health record data. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

Kaiser Permanente of Colorado (KPCO) - LiveWell and Active Living

A ten-month, $60,000 grant from Kaiser Permanente. Major goals: To support data analysis and reporting on the results of the LiveWell and Active Living grants through 2019. The Kaiser Permanente Washington Health Research Institute lead investigator is Erin Hertel.

Leveraging Existing Aging Research Networks to Investigate Traumatic Brain Injury (TBI) and Alzheimer’s Disease/ Alzheimer’s Disease-Related Diseases (AD/ADRD) Risk

A five-year, $367,096 grant from National Institute on Aging. Major goals: To link and harmonize data from multiple research sites to improve the power and our ability to detect the relationship of Traumatic Brain Injury (TBI) and risk of late life dementias. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.


March 2019

KPWHRI recently received word of 4 new awards.

4H-Well Connected Communities Initiative Evaluation Planning

A three-month, $22,000 grant from National 4-H Council. Major goals: To lead a collaborative evaluation planning effort to articulate to Well Connected Communities (WCC) Leadership Team the value of a 10-year study of the WCC Initiative and to draft framework and methodology for a multi-year longitudinal study, including potential annual benchmarks to be assessed. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

An Alternate Health Eating Index (AHEI) Dietary Intervention to Reduce Pain in Women with Endometriosis

A four-year, $317,965 grant from National Institute of Nursing Research. Major goals: To better understand the role of pelvic and abdominal pain in those with endometriosis and investigate whether dietary modifications, specifically adhering to a prescribed meal plan, will help alleviate or change pain patterns. The Kaiser Permanente Washington Health Research Institute lead investigator is Aruna Kamineni.

Developing a Model for Interactive Screening for Social Determinants of Health

A ten-month, $39,964 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To conduct a review of articles and grey literature that describe the type of training people conducting screening are given, timing of screening, goals of screening, and interactions between person conducting the screening and the patient. To observe and document at least two current approaches for in-person Social Determinants of Health (SDH) Screening. To interview patients and clinic staff about the screening experience. To develop a conceptual model of the screening interaction that identifies key competencies and discrete methods/approaches to in-person screening. The Kaiser Permanente Washington Health Research Institute lead investigator is Clarissa Hsu.

Glucose Control and Preventable Hospitalization in Persons with Dementia and Diabetes

A two-year, $80,753 grant from National Institute on Aging. Major goals: To elucidate the association between Alzheimer’s Disease and Related Disorders onset and potentially preventable hospitalizations and suggest optimal glycemic levels for diabetes management in persons living with these comorbid conditions with regard to overall and potentially avoidable hospitalization outcomes. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.


February 2019

KPWHRI recently received word of 6 new awards.

Integrating Addiction Research in Health Systems - the Addiction Research Network – Supplement. PRimary care Opioid Use Disorders Treatment Trial (PROUD) Economics Ancillary Study

A two-year, $196,762 grant from National Institute on Drug Abuse. Major goals: To leverage the existing research infrastructure and cohort of the PROUD trial.  The specific aims are to (1) Estimate the start-up and ongoing management costs of the PROUD intervention; (2) Assess costs associated with healthcare utilization for patients who receive primary care treatment in PROUD intervention and Utica Park (UPC) clinics, and have been identified with recognized Opioid Use Disorders (OUDs) prior to clinic randomization; and (3) Estimate the economic value of the PROUD intervention, measured as net monetary benefit (NMB, incremental benefit – incremental cost), from the healthcare sector perspective. The Kaiser Permanente Washington Health Research Institute lead investigator is Katharine A. Bradley.

KP Southern California Technical Assistance

A one-month, $4,000 grant from Kaiser Permanente Community Benefit. Major goals: To analyze a pre/post/delayed post qualitative and quantitative survey data from implementation of three Educational Theater Programs in Southern California region during fall 2019. The programs include Amazing Food Detective, What Goes Around, and It’s Stop Time, all plays shown in public schools throughout the region. The Kaiser Permanente Washington Health Research Institute lead investigator is Elena S. Kuo.

Long-Term Comparative Effectiveness of Sleeve Gastrectomy

A four-year, $122,285 grant from National Institute of Diabetes and Digestive and Kidney Diseases. Major goals: To compare the long-term safety of sleeve gastrectomy vs. gastric bypass; to evaluate long-term health care use and expenditures of sleeve gastrectomy vs. gastric bypass; and to evaluate heterogeneity in safety, health care use, and expenditures for sleeve gastrectomy vs. gastric bypass. The Kaiser Permanente Washington Health Research Institute lead investigator is David E. Arterburn.

Lung Cancer Screening Community Meetings

A six-month, $10,777 grant from Kaiser Permanente Washington Health Research Institute Directors Project Resource Fund. Major goals: To host community meetings on South King County/Pierce County and on the Peninsula regarding lung cancer screening for engagement in a Patient-Centered Outcomes Research Institute (PCORI) application and potential award. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Montana Health Care Foundation: Evaluation and Metrics Consulting

A five-month, $38,998 grant from Montana Healthcare Foundation. Major goals: To help the Foundation revise and strengthen their approach to measuring the impact of their work on community health outcomes. The Kaiser Permanente Washington Health Research Institute lead investigator is Allen Cheadle.

Practice-Specific Evaluation for Trauma- and Resilience-Informed Learning Networks

A one-year, $30,000 grant from Genentech. Major goals: To provide evaluation and measurement support for the Resilient Beginnings Collaborative, a learning collaborative supporting Bay Area institutions in being more trauma and resiliency informed. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Schafer.


January 2019

KPWHRI recently received word of 25 new awards.

Alliance of Randomized Trials of Medicine versus Metabolic Surgery in Type 2 Diabetes (ARMSS-T2D) Consortium

A four-year, $176,530 grant from National Institute of Diabetes and Digestive and Kidney Diseases. Major goals: To determine the long-term durability of diabetes remission after randomization to intensive medical/weight management (IMWM) or bariatric surgery; to assess the long-term (7 year) efficacy and safety of bariatric surgery compared to IMWM; and to identify clinical predictors of diabetes remission and relapse. The Kaiser Permanente Washington Health Research Institute lead investigator is David E. Arterburn.

CATALyST: Consortium for Applied Training to Advance the Learning Health System with Scholars/Trainees

A one-year, $52,902 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: We are seeking supplemental Development Fund support for our recently-funded K12 scholar program. The Kaiser Permanente Washington Health Research Institute lead investigator is Diana S. Buist.

Cooperative Pain Education and Self-Management: Expanding Treatment for Real-World Access

A two-year, $97,969 grant from National Center for Complementary and Integrative Health. Major goals: To conduct a pragmatic trial to examine the real-world effectiveness of an interactive voice response-based form of cognitive behavioral therapy for chronic pain called Cooperative Pain Education and Self Management. This trial will recruit 764 veterans (male and female) from among the Women's Health Practice Based Network sites, a network of Veteran’s Affairs (VA) health center sites. The Kaiser Permanente Washington Health Research Institute lead investigator is Lynn DeBar.

Cost of Care Conversations in Cancer Patients: Recommendations for Implementation and Training

A seven-month, $10,550 grant from Robert Wood Johnson Foundation. Major goals: To conduct secondary analysis of the findings of two Robert Wood Johnson Foundation (RWJF) Cost of Care Conversations projects, those led by Nora Henrikson and Maria Pisu. The Kaiser Permanente Washington Health Research Institute lead investigator is Nora Henrikson.

Detecting Cost-Related Cancer Treatment Conversations in the Electronic Medical Record

A one-year, $30,000 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To develop pilot data that describes the proportion of providers, patients and Electronic Medical Record (EMR) notes that have recorded cost conversations and develop an automated Natural Language Processing (NLP) algorithm capable of identifying cost-related conversations at scale. The Kaiser Permanente Washington Health Research Institute lead investigator is Kai Yeung.

Developing and Piloting Technology-Driven Shared Decision-Making for Persistent Pain Treatment in the Primary Care Setting

A one-year, $85,214 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To develop and pilot a technology-based build out of a paper-based tool that explains pain and provides a rationale for the uptake of broader non-pharmacotherapy treatment approaches. The prototype developed would serve as a foundation for a shared decision-making tool that would have both direct patient and healthcare provider interfaces to support better understanding of nonpharmacotherapy options and the motivation for their use. This project would involve a partnership with Artefact, a small technology design firm in Seattle that has experience with health-related technology tools and is well positioned to help build out and partner on usability testing on this next phase of this element of this critical tool for our overall research on promoting behavioral approaches to chronic pain management at the point of service. The Kaiser Permanente Washington Health Research Institute lead investigator is Lynn DeBar.

Exploring and Acquiring New Data Sources for Pregnancy Research

A one-year, $76,918 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To investigate, explore and acquire new data sources to support grants about medication safety in pregnancy. Two data sources to be explored including New Zealand country-wide data on pregnancy exposure and outcomes and Washington State's new "all payer" claims database which we will exploring linking with Washington state birth certificate data. We will also extract and explore KPWA's own internal data from the women's health Behavioral Health questionnaire including depression and substance use screening to understand the extent of availability and missingness of those data for pregnancies cared for within KPWA's integrated group practice. The Kaiser Permanente Washington Health Research Institute lead investigator is Sascha Dublin.

Financial Strain on Mental and Physical Health: Does Race/Ethnicity Matter?

A nine-month, $20,656 grant from National Institute on Aging. Major goals: To determine the extent to which financial stress might affect cognitive performance and function in older persons using data from the Health and Retirement Study. This is a supplement to a K award looking at other effects of financial stress. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.

Impact of Medicare Transitions in the Washington State-All-Payer-Claims Database

A one-year, $52,544 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To complete analyses begun in 2018 of the Washington All-Payer Claims Database (WA-APCD) to describe the direction and magnitude of changes in benefits and provider networks, defined using standard, and innovative methods for different sociodemographic, clinical, and insured populations. The WA-APCD contains the claims experience of 3.7 million individuals insured through the health insurance exchange, Medicaid, fully-insured employers, Medicare advantage and Medicare fee-for-service. The Kaiser Permanente Washington Health Research Institute lead investigator is Kai Yeung.

Implementation Science and Practice

A six-month, $40,000 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To generate a model, infrastructure, data structures, products, and funding streams for advancing an integrated implementation science and practice model for MacColl. The Kaiser Permanente Washington Health Research Institute lead investigator is Katie Coleman.

Improving Measures of Social Determinants of Health in the Virtual Data Warehouse (VDW) Using Census Data

A one-year, $33,102 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To calculate 6 validated social determinants of health indices for inclusion in the Virtual Data Warehouse (VDW) and to test these measures. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold. (R218167001)

Kaiser Permanente Transforming Cardiovascular Care in our Communities (TC3) Initiative Evaluation

A three-year, $250,000 grant from Kaiser Foundation Hospitals Southern California Region. Major goals: To support program improvement (formative) and evaluate success (summative) of the Transforming Cardiovascular Care in our Communities (TC3) initiative. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

Making Medical Decisions with BRCA 1/2

A one-year, $59,957 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To understand the factors important patients making decisions about their health and about family building in the context of a BRCA genetic mutation using data available on social media. This study will also explore women’s perspectives and decision making about genetic testing of embryos before implantation using social media data. This study will test the feasibility of using social media data to identify crucial gap in care for women who are BRCA1 or 2 carriers, many of whom are also women of child bearing age and provide an understanding of decision-making processes and factors related to fertility preservation and family building for women with genetic predisposition to cancer to better align care with patient preferences. The Kaiser Permanente Washington Health Research Institute lead investigator is Marlaine Gray.

Novel Computational Techniques to Detect the Relationship Between Sitting Patterns and Metabolic Syndrome in Existing Cohort Studies

A five-year, $170,689 grant from National Institute of Diabetes and Digestive and Kidney Diseases. Major goals: To use data from the Adult Changes in Thought Study to develop new machine learning methods for estimating sitting patterns from hip worn accelerometer data. The Kaiser Permanente Washington Health Research Institute lead investigator is Dori E. Rosenberg.

North Sound Accountable Community of Health (NSACH)-Eval Planning

A nine-month, $60,000 grant from North Sound ACH. Major goals: To support North Sound Accountable Community of Health (NSACH) in designing an evaluation for their transformation projects. The Kaiser Permanente Washington Health Research Institute lead investigator is Erin Hertel.

Nutrition Intervention for Weight Loss at Kaiser Permanente Washington (KPWA)

A six-month, $29,512 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To conduct an environmental scan of Kaiser Permanente (KP) regions and similar organizations (HCSRN members and VA); to establish a Kaiser Permanente Washington (KPWA) Weight Management (WM) Learning Health System (LHS) Team; to implement a small 6-month pilot of a novel, online nutritional coaching intervention with a “flexible dieting” approach (www.workingagainstgravity.com; “WAG”), and to evaluate its impact on body weight, blood pressure, fasting blood sugar, and cholesterol; and to qualitatively evaluate the experience of KPWA members with the WAG and Wellness Coaching by Phone programs. The Kaiser Permanente Washington Health Research Institute lead investigator is David E. Arterburn.

Operationalizing Behavioral Theory for Mobile Health (mHealth): Dynamics, Context, and Personalization

A four-year, $307,429 grant from Department of Health and Human Services. Major goals: To develop a framework for modeling dynamics of health behaviors in naturalistic and intervention settings, a dynamic measure of behavioral determinants from social-cognitive theory, and a dynamic version of the social-cognitive theory and validate the developed models on longitudinal physical-activity data collected through the project's year-long study. The Kaiser Permanente Washington Health Research Institute lead investigator is Predrag Klasnja.

Patient-Centered Design to Improving Lung Cancer Screening Uptake

A one-year, $85,236 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To develop lung cancer screening interventions to improve uptake and maintenance within care delivery using patient-centered and user-centered design principles. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Public Health Institute (PHI)-National Leadership Academy for the Public’s Health (NLAPH) C8

A two-year, $60,000 grant from Centers for Disease Control and Prevention. Major goals: To evaluate the 8th cohort of the National Leadership Academy for the Public's Health (NLAPH) and provide the program team with information to inform the program development. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk (Supplement)

A one-year, $54,389 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To provide supplementary support for research regarding physical activity, sedentary behavior, and venous thromboembolism risk. This project particularly supports the implementation of a case-crossover study set in Kaiser Permanente Washington, in which we will evaluate short-term risk of venous thromboembolism following physical activity. The Kaiser Permanente Washington Health Research Institute lead investigator is Laura Harrington. (R218148001)

Piloting the Implementation of Mobile Health (mHealth) for Substance Use Disorders in Primary Care

A one-year, $50,000 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To pilot the implementation of a digital treatment for substance use disorders in Kaiser Permanente primary care clinics. The Kaiser Permanente Washington Health Research Institute lead investigator is Joseph E. Glass.

Risk of New Malignancies Following Breast Cancer

A one-year, $149,828 grant from National Cancer Institute. Major goals: This retrospective population-based cohort study of women diagnosed with breast cancer will evaluate the effects of breast cancer treatments and mammographic density on risk of contralateral breast cancer (CBC), other second cancers, and cause of death. The main purpose of this study is to understand the relationship between breast cancer treatment and the occurrence of other cancers. This is a continuation study. The Kaiser Permanente Washington Health Research Institute lead investigator is Diana S. Buist.

Susceptibility Gene for Erectile Dysfunction

A six-month, $19,746 grant from National Institute of Diabetes and Digestive and Kidney Diseases. Major goals: To develop a novel framework that can be used to investigate and replicate the genetic component of Erectile Dysfunction (ED) in a highly cost-effective manner. To do this, we will expand on previous work examining genetic risk factors for ED among men with diabetes. We will perform new genome-wide association study (GWAS) to determine whether genetic risk operates through the same causal pathway as in nondiabetic men. Last, we will examine genetic predictors of disease severity, including age of onset of ED and therapeutic response. This will allow us to develop a list of candidate genes to push forward into animal models, for biomarker prediction, and for translational clinical studies of genetic ED risk factors. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.

To Model Member Choices Based on Shopping for Referred Services

A six-month, $12,842 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To model member choices based on shopping for referred services. To create a data set that will support external applications on member utilization for those high deductible health plans. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold.

Tobacco Quitline Opioid Use - MI and Navigation Intervention

A one-year, $69,455 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To conduct a survey of KP members who enrolled in the Tobacco Quitline in the past 6 months to assess their use of opioids and interest in quitting opioids. We might also ask about tobacco. The long-term goal would be to partner with Optum to do a brief motivational intervention and refer people to treatment. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer B. McClure.