may 2020

KPWHRI recently received word of 4 new awards.

Alpha Blockers and COVID-19 Infection

A 6-month, $20,000 grant from John Hopkins University. Major goals: To develop protocols, tools, and resources to support a study of COVID-19 infection and severe morbidity in relation to use of alpha blocker medications. The principal investigator is Sascha Dublin.

COVID-19 Patient Research Registry

A 5-month, $52,222 grant from the Kaiser Permanente Washington Health Research Institute Innovation Fund. Major goals: To establish and operate a registry of KP Washington members who have tested positive for SARS CoV-2/COVID-19 and who are willing to be contacted about research Kaiser Permanente Washington Health Research Institute (KPWHRI) is doing about SARS CoV-2/COVID-19. Once the registry is established, KPWHRI investigators will apply for use of its member information to registry’s governing committee, led by Dr. Michael L. Jackson. This committee will regulate the frequency with which registry members can be contacted to prevent inundating them with research invitations. The principal investigator is Michael L. Jackson.

Leveraging Machine Learning to Improve Risk Prediction for Chemotherapy Induced Neuropathy

A 4-year, $850,510 grant from the National Cancer Institute. Major goals: To develop and validate a machine learning enabled predictive model to identify patients at high risk for acute (less than 14 days) and chronic (14 days or more) chemotherapy associated peripheral neuropathy (CAPN) following start of chemotherapy treatment in a large integrated care setting. To validate externally the risk prediction model in a second integrated health system. To estimate the effect of changing the initial chemotherapy-based treatment plan (e.g., mono compared to combination therapy, reduced compared to full dose) on the risk of CAPN and 5-year cancer survival rates and possible effect heterogeneity (race, ethnicity, and age) among patients at high risk for CAPN using causal inference methods. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

Leveraging Tumor Registries and Pathology Specimens to Facilitate Genetic Testing and Traceback for Ovarian Cancer

A 4-year, $453,288 grant from the National Cancer Institute. Major goals: To design, implement, and ethically evaluate a health care system-led notification process for familial (genetic) disease risk. To do this we will conduct focus groups to determine culturally appropriate messages for sending to ovarian cancer patients and alerting them to availability of testing. We will then invite members with a new diagnosis of ovarian cancer to receive genetic counseling and testing per usual clinical processes. Finally, we will conduct follow up interviews with participants and providers to assess the utility of the process. The Kaiser Permanente Washington Health Research Institute lead investigator is Nora Henrikson.


april 2020

KPWHRI recently received word of 4 new awards.

A Platform for Cell Type-Level Transcriptomic, Epigenomic, and Spatial Interrogation of Alzheimer’s Disease

A 5-year, $640,898 grant from the National Institute on Aging. Major goals: To leverage single cell transcriptomic, epigenomic and highly multiplexed molecular spatial analysis methods - established through the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative and similar efforts - to develop a platform for detailed cell type phenotypic characterization of Alzheimer’s Disease (AD) pathology. These tools will be applied to generate a foundational understanding of the molecular and structural progression of Alzheimer’s Disease, identify transcriptional and spatial hallmarks of AD pathology and affected molecular pathways, and create a catalytic open access dataset for the research community. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson

BRCA (BReast CAncer Gene) Cohort - Radiotherapy and Electronic Health Records (EHR) Data Extension

A 2-year, $249,997 grant from the National Cancer Institute. Major goals: This study is evaluating the late-effects breast cancer treatments in a large cohort of breast cancer survivors. The principal investigator is Diana S. Buist.

CityHealth Evaluation

A 2-month, $12,500 grant from the de Beaumont Foundation. Major goals: To understand the policy adoption process in CityHealth cities so that the program can improve moving forward. The principal investigator is Erin Hertel.

Sentinel Common Data Model (SCDM) 8.0.0 Implementation: Addition of a Prescribing table, Addition of Code Types for Dispensing, Diagnosis, and Procedure tables, and Enhancements for Provider and Facility Identification

A 13-month, $59,834 grant from the Food and Drug Administration. Major goals: To enhance the Sentinel Common Data Model (SCDM) by adding a prescribing table, international value sets, and modifications to several existing SCDM tables to better capture provider and facility information. To develop the necessary infrastructure to support routine updates to all revised SCDM tables, by all participating Data Partners. This includes modifications to existing infrastructure to ensure that both distributed programs and tools, as well as local support tools (such as tracking systems, workflows, Statistical Analysis System (SAS) programs), and relevant test environments are updated to reflect the new data and processes. Lastly, to modify the SCDM to achieve efficiency gains and to improve program execution time. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise M. Boudreau.


march 2020

KPWHRI recently received word of 4 new awards.

Biologics and Biosimilars Collective Intelligence Consortium 2020 Baseline Contract

A 1-year, $32,029 grant from the Biologics and Biosimiliars Collective Intelligence Consortium. Major goals: To develop preliminary data to pursue research on comparative effectiveness of Biologics and Biosimilars. The principal investigator is Kai Yeung.

Center for Care Innovations California Adverse Childhood Events (ACEs) Training and Learning Network Evaluation

A 2-year, $250,000 grant from the Center for Care Innovations. Major goals: To access changes in organizations’ capabilities, staff experience, and clinic-level outcomes related to implementing Adverse Childhood Events (ACEs) screening. To understand the contribution of the learning collaborative to organizations’ progress. To provide real time information back to program stakeholders to improve the learning collaborative. The principal investigator is Maggie Jones.

Modeling to Minimize Detection Bias in Cancer Risk Prediction Studies

A 5-year, $258,895 grant from the National Cancer Institute. Major goals: To develop methods that will help people understand how common risk factors like family history and breast density affect their risk of getting cancer rather than their risk of getting a cancer diagnosis. The Kaiser Permanente Washington Health Research Institute lead investigator is Ellen O'Meara.

The California Endowment (TCE) – California Leadership Academy for the Public’s Health (CaLAPH) Cohort 6

A 1-year, $5,000 grant from The California Endowment. Major goals: To assess competency changes in the California Leadership Academy for the Public’s Health (CaLAPH) participants over the course of the program. To assess the contribution of the program to individual participants and communities. To provide results back to the Center for Health Leadership and Practice (CHLP), and to improve this and subsequent programs. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.


february 2020

KPWHRI recently received word of 1 new award.

A Study of Polycystic Ovary Syndrome: Incidence, Case-finding and Patterns of Care in a United States Population-Based Cohort

A 2-year, $791,071 grant from Bayer AG. Major goals: To track the annual rates of incident Polycystic Ovary Syndrome in a US population-based cohort of women during a 12-year interval (2006-2017), and to track the trends in estimated PCOS incidence over a 12-year interval (2006-2017). To estimate the prevalence of PCOS in a US population-based cohort of women. To develop and validate an automated case-finding algorithm for incident PCOS in a sample of women randomly selected from a US population-based cohort. To assess post-PCOS diagnosis treatment and utilization patterns in a real-world setting, including surgical interventions, pharmacotherapy, diagnoses of additional conditions, and overall health care utilization for up to 5 years from incident PCOS diagnosis. To identify whether PCOS diagnosis is associated with selected morbidities (e.g. Type 2 diabetes, myocardial infarction (MI), stroke, depression, obesity) in the 3-5 years post-diagnosis. The principal investigator is Onchee Yu.


January 2020

KPWHRI recently received word of 5 new awards.

Implementation and Effectiveness of Multicomponent Genomic Health Care Interventions for Hereditary Breast and Ovarian Cancer Prevention: A Natural Experiment in an Integrated Health System

A 3-year, $101,294 grant from the National Human Genome Research Institute. Major goals: To develop career goals in genomic implementation in clinical settings for hereditary breast and ovarian cancer. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Livewell and Active Living

A 6-month, $10,000 grant from Kaiser Foundation Hospitals. Major goals: To analyze and report on the Spring 2020 Active Living grants data. The Center for Community Health and Evaluation (CCHE) has already analyzed and reported on data provided in 2019, and this new data will be folded into the current slide doc once analyzed. The Kaiser Permanente Washington Health Research Institute lead investigator is Erin Hertel.

North Sound Accountable Community Health (ACH) Collaboration Evaluation

A 1-year, $40,000 grant from the North Sound Accountable Community of Health (ACH). Major goals: The Arcora Foundation is funding a local impact network (LIN) in the North Sound Accountable Communities of Health (NSACH) region to respond to oral health needs and disparities in Snohomish, Skagit, Whatcom, San Juan, and Island counties. The LINs are designed to build local capacity across organizations and community stakeholders. The major goals of this evaluation project are to understand the implementation progress and outcomes and to understand the level of collaboration and the strength of the Oral Health LIN. The principal investigator is Erin Hertel.

Planning Phase of Overuse and Trust in an Accountable Care Organization (ACO) Setting Evaluation

A 7-month, $54,394 grant from the Robert Wood Johnson Foundation. Major goals: The goals of this grant are to establish partnership with up to 10 accountable care organizations (ACO), to administer the high-value care survey to clinicians in each ACO, to work with stakeholders to develop agreed upon measures of low-value care for patients with dementia, and to develop a multi-level strategy to reduce low-value dementia care. The Kaiser Permanente Washington Health Research Institute lead investigator is Michael L. Parchman.

The Bariatric Experience Long Term (BELONG) II for Racial and Ethnic Minority Patients

A 4-year, $443,370 grant from the National Institute of Diabetes and Digestive and Kidney Diseases. Major goals: To understand the patient experience of bariatric surgery from the perspective of minority and ethnically diverse populations, namely African American and Hispanic patients.  Rich qualitative analysis will yield patient perspectives of the challenges and facilitators of weight loss success, and these insights can inform and improve patient care. The Kaiser Permanente Washington Health Research Institute lead investigator is Marlaine Gray.