april 2021

KPWHRI recently received word of 5 new awards.

Birth Bundle Project Year 2

A 1-year, $19,800 grant from Public Health Seattle and King County. Major goals: In addition to supporting the Birth Bundle Project (BBP) to build capacity and sustainable systems, we will seek to answer the following questions:

  1. Are providers being trained systematically and successfully to do this work?
  2. Is BBP enrolling families successfully? 
  3. Are outcomes improving for BBP clients?
  4. What are the barriers, challenges, successes, and lessons learned from implementing BBP?

The Kaiser Permanente Washington Health Research Institute lead investigator is Elena Kuo.

Clinical Care Gaps and Unmet Needs in Adolescent and Young Adult (AYA) Cancers (Cores A & B)

A 5-year, $2,046,914 grant from the National Cancer Institute. Major goals: This program of research focuses on cancer care and outcomes for people diagnosed with cancer during the adolescent and young adult (AYA) age range, from 15 to 39 years old. Project 1 focuses on fertility concerns and use of reproductive health services and their impact on cancer treatment. Project 2 focuses on care transitions from active cancer treatment to surveillance and ancillary services in the period 2 to 5 years after diagnosis. Project 3 documents medical conditions and late effects that occur in AYA cancer survivors and identifies factors that influence likelihood of developing these conditions. These projects are supported by 3 cores: an administrative core, a biostatistics and data harmonization shared resource, and a survey shared resource. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

GlaxoSmithKline Pregnancy Exposure Study (Phase I)

A 2-year, $302,486 grant from GlaxoSmithKline. Major goals: The objectives of the study are to characterize the use of certain new medications during pregnancy specifically and more generally among women of childbearing years (ages 10 to 54 years). The study will also describe women of childbearing years and pregnant women with systemic lupus erythematosus (SLE) who are unexposed to the medications of interest during pregnancy. The Kaiser Permanente Washington Health Research Institute lead investigator is Sascha Dublin.

Maintenance of the Innovation Center (Year 2)

A 1-year, $47,640 grant from the Food and Drug Administration. Major goals: The major goals of this project are to establish and to create the organizational structure, administrative processes, and governance for the Innovation Center (IC) and its network of scientific collaborators. The IC shall build and maintain a diverse team with expertise in epidemiology, clinical medicine, pharmacy, statistics, health informatics, data science (specifically, artificial intelligence [natural language processing, machine learning]), network operations, and training to achieve the goals of this requirement, and shall be capable of initiating up to 7 new projects. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer Nelson.

SARS-CoV-2 Serology and Vaccination Response

A 1-year, $66,048 grant from the Garfield Memorial Fund. Major goals: The major goals of the project are to evaluate antibody responses following SARS-CoV-2 vaccination and to estimate risks of "long COVID" and whether there are serologic markers after initial infection that predict long COVID risk. The Kaiser Permanente Washington Health Research Institute lead investigator is Michael L. Jackson.


March 2021

KPWHRI recently received word of 11 new awards.

Analysis of Studies of Activity and Thrombosis

A 1-year, $20,476 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The major goal of this project is to improve our understanding of physical activity, sedentary behavior, and venous thromboembolism risk by evaluating self-reported and accelerometer-measured physical activity and sedentary behavior in relation to hemostatic factor levels and incident venous thromboembolism risk in the setting of the Women’s Health Initiative. The KPWHRI lead investigator is Laura Harrington.

Cannabis Use in Pregnancy (CIP): Qualitative Results Paper

A 1-year, $10,241 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Note: This qualitative study was completed in 2018. It has ongoing IRB approval and was reviewed and approved by Tanya Matthews. We interviewed 15 KPWA women who had reported using cannabis during pregnancy about their reasons for use. We audio-recorded and transcribed the interviews and created a coding memo by the end of the study. Major goals: The goal of this project is to continue manuscript writing, with Linda Kiel as lead author (original project PM and coder) and Clarissa Hsu (co-investigator, interviewer and co-author), and to submit the manuscript, with acceptance by the end of the year. The KPWHRI lead investigator is Gwen Lapham.

Elevating Consumer Voice in Phase 2 of the Delta Center for a Thriving Safety Net Initiative

A 3-year, $450,592 grant from the Robert Wood Johnson Foundation. Major goals: The major goals of this project are to build capacity of state primary care and behavioral health associations to support value-based pay and care in 20 states, to explore how to elevate consumer voice in policy and practice improvements, and to share learnings with the field. The Kaiser Permanente Washington Health Research Institute lead investigator is Katie Coleman.

I See You — Improved Social and Economic Outcomes (ISEO): Elevating Diverse Stakeholder Perspectives in this Rural Landscape Strategy Assessment

A 2-year, $499,253 grant from the Robert Wood Johnson Foundation. Major goals: The strategy assessment will articulate the overarching theory of change for this body of work; examine the strategic decisions made in developing, funding, and managing this body of work; gauge the progress made toward the intended outcomes; and provide consultations for the role that the Robert Wood Johnson Foundation could play in advancing opportunity, health, and equity in rural communities moving forward. The Kaiser Permanente Washington Health Research Institute lead investigator is Emily Bourcier.

Kaiser Permanente Washington Health Research Institute Mental Health Advocate Group

A 1-year, $6,330 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The major goals of this project are to develop and sustain the mental health advocacy group, to establish infrastructure allowing Kaiser Permanente Washington employees with lived experience of mental health problems to provide strategic consultation for behavioral health research, and to destigmatize mental illness at KPWHRI and foster a culture of empathy and transparency. The KPWHRI lead investigator is Janna Webbon.

Medication Orders Data Investigation

A 1-year, $16,118 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The major goal of this project is to better understand and document linkage of pharmacy records between medications that are ordered versus those that get dispensed. The KPWHRI lead investigator is Dustin Key.

Mom Baby Link Infrastructure Update

A 1-year, $12,099 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The goal of this project is to update the Mother-Baby linkage file to include data through 2020 and to disseminate information about the updated dataset within KPWHRI. The KPWHRI lead investigator is Sharon Fuller.

MyPath: A Patient-Centered Web-Based Intervention to Improve Reproductive Planning for Women Veterans

A 4-year, $55,674 grant from VA Health Services Research & Development. Major goals: The goal of MyPath is to test a novel patient-facing decision-support tool for reproductive care decisions and determine its impact on communication self-efficacy, knowledge, decisional conflict, and satisfaction with care. The Kaiser Permanente Washington Health Research Institute lead investigator is David Arterburn.

Paws Unite: Prototyping a Social Connection Innovation

A 1-year, $7,620 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The major goals of this project are to collect preliminary data on the feasibility of an intervention to address loneliness that will be designed around the idea of visiting socially isolated neighbors on walks with our dogs, to conduct an environmental scan by posting queries on the idea to social media sites, and to conduct semi-structured interviews with community-based stakeholders and Kaiser Permanente Washington member advisors. The KPWHRI lead investigator is Leah Tuzzio.

Practical Awareness-Based Strategies for Eating

A 1-year, $50,048 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: We propose a 6-month randomized trial involving 20 Kaiser Permanente Washington (KPWA) patients with BMI =>25 kg/m2 (overweight or obesity). These patients will be assigned randomly to 1 of 2 approaches to Eat Right Now (a mindfulness based smartphone app) for weight loss: Approach 1: Eat Right Now Only (the Eat Right Now intervention plus educational materials, weekly physical activity goals, and a wi-fi-enabled digital body weight scale); Approach 2: Eat Right Now PLUS Coaching (everything in Approach 1, plus 24-weeks of asynchronous coaching by trained KPWA facilitators of the Eat Right Now intervention). The KPWHRI lead investigator is David Arterburn.

Research Data Warehouse Communication Strategy

A 1-year, $31,200 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The goal of this project is to develop and implement a communication strategy for the research data warehouse. The KPWHRI lead investigator is Yonah Karp.


FEbruary 2021

KPWHRI recently received word of 8 new awards.

Novel Micro-Simulation Model Approach to Estimate and Mitigate Thyroid Cancer Overdiagnosis

A 5-year, $433,004 grant from the National Cancer Institute. Major goals: To develop and validate a microsimulation model to predict overdiagnosis of thyroid cancer. As part of this model, we will estimate the proportion of overdiagnosis due to health care utilization (for example, imaging and other tests). The Kaiser Permanente Washington Health Research Institute lead investigator is Erin Bowles.

Social Needs Network for Evaluation and Translation (SONNET): Addressing the Social, Economic, and Behavioral Needs for Kaiser Permanente Members

A 1-year, $542,609 grant from Kaiser Program Office Community Benefit. Major goals: The SONNET initiative is an inter-regional network of researchers and evaluators interested in understanding the role that social determinants of health play in the health of our members and in assessing the effectiveness of interventions to address social determinants. The Kaiser Permanente Washington Health Research Institute lead investigator is Katie Coleman.

Comparative Modeling of Precision Breast Cancer Control Across the Translational Continuum

A 5-year, $253,811 grant from the National Cancer Institute. Major goals: To evaluate the benefits and harms of precision screening strategies for breast cancer based on breast density and 5-year absolute risk of breast cancer, and to determine the best screening strategy in women with type 2 diabetes. The Kaiser Permanente Washington Health Research Institute lead investigator is Ellen O'Meara.

COVID-19 Data Resource Implementation: Sentinel Common Data Model v7.1.0 and Rapid COVID-19 Sentinel Distributed Database

A 1-year, $66,300 grant from the Food and Drug Administration (FDA). Major goals: The major goals of a Rapid COVID-19 Sentinel Distributed Database project are to use the FDA’s Sentinel Common Data Model (SCDM) v7.X.X nomenclature to avoid complication with the ongoing implementation of SCDM v8.0.0. For the duration of the project, participating data partners (DPs) will maintain two separate databases: one production-level curated and quality-checked database used for routine querying, and the Rapid COVID-19 Sentinel Distributed Database, which has an abbreviated quality assurance and quality control process. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise Boudreau.

Enhancing Causal Inference in the Sentinel System

A 1-year, $44,480 grant from the Food and Drug Administration (FDA). Major goals: The major goals of this project are to focus on comparing the performance of targeted learning methods with causal inference approaches currently available to the FDA’s Sentinel System in data environments that include linked insurance claims and electronic health record (EHR) data. The proposal will further assess practical aspects of the feasibility of how such approaches might be implemented in a distributed environment. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer Nelson.

Sentinel: Horizon Scan of Electronic Health Record Databases

A 1-year, $15,561 grant from the Food and Drug Administration (FDA). Major goals: This project will enhance the FDA’s Sentinel medical products safety surveillance methods. Existing surveillance methods depend heavily on structured claims data, but these data often lack precision for capturing exposures, important covariates, and outcomes. Information derived from clinical notes via natural language processing (NLP) and other unstructured data such as laboratory findings will be used to investigate medical products safety with greater precision — through the lens of the clinician rather than the insurer. The Kaiser Permanente Washington Health Research Institute lead investigator is David Carrell.

Sentinel Year 7 (Operational Year 2021) Infrastructure

A 1-year, $99,744 grant from the Food and Drug Administration (FDA). Major goals: The major goals of this project are to continue the work required for the FDA’s Sentinel data partners (DPs) under the operational year 2021 Infrastructure work order. Most of the requirements involve DP staff to run data requests or return data and documents of various types to the Sentinel Operations Center via the Sentinel PopMedNet Distributed Query Tool System. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise Boudreau.

Sentinel Year 7 (Operational Year 2021) Querying

A 1-year, $51,165 grant from the Food and Drug Administration (FDA). Major goals: The major goals of this project are to support the routine querying tasks required for the FDA’s Sentinel data partners (DPs) in operational year 2021. Routine querying involves execution of standard modular programs, sometimes supplemented with minimal amounts of custom coding (developed by the Sentinel Operations Center), against a DP’s production Sentinel Distributed Database — that is, last approved refresh or ETL (extract, transform, load). DPs will receive query requests and be asked to “opt in” by executing the routine query and transmitting aggregated results back to the Sentinel Operations Center. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise Boudreau.


January 2021

KPWHRI recently received word of 4 new awards.

Assisted Identification and Navigation of Early Mental Health Symptoms in Children

A 4-year, $3,132,781 grant from the National Institute of Mental Health. Major goals: To conduct a pragmatic trial of early intervention (mental health navigation support supplemented by clinic-to-home telemental health services, when warranted) among children and youth 4-12 years of age. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold.

Kaiser Permanente National Cancer Institute (NCI) National Community Oncology Research Program, NCI Community Oncology Research Program Renewal

A 5-year, $324,996 grant from the NCI. Major goals: To develop the NCI National Community Oncology Research Program. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Moderna's External Safety Advisory Board (ESAB) for mRNA-1273

A 1-year, $27,857 grant from ModernaTX, Inc. Major goals: The major aims of this project are to provide statistical expertise in vaccine safety as part of Moderna's External Safety Advisory Board (ESAB) for mRNA-1273 (their candidate COVID-19 vaccine), as Moderna prepares to receive an Emergency Use Authorization from the Food and Drug Administration (FDA).  The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer Nelson.

Vaccine Safety Datalink Project (VSD) COVID Participation- Request for Task Order Proposal

A 3-year, $280,310 grant from the Centers for Disease Control and Prevention. Major goals: The purpose of this task order is for the contractors to contribute to the main functions of VSD COVID-19 vaccine safety activities. The work from this task order will support and contribute to the COVID-19 vaccine safety work of the VSD. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.