April 2022

Kaiser Permanente Washington Health Research Institute recently received word of 3 new awards.

Observational, Prospective Cohort Study of the Immunogenicity and Safety of SARS-CoV-2 Vaccines Administered during Pregnancy or Postpartum, and Evaluation of Antibody Transfer and Durability in Infants

A 1-year, $2,114,527 grant from the National Institute of Allergy and Infectious Diseases. Major goals: The major goals of this project are to evaluate the safety and immunogenicity of SARS-CoV-2 vaccines in pregnant and postpartum women. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.

Opportunities for an Electronic Patient Portal to Meet Adolescent Sexual and Reproductive Health Care Needs

A 1-year, $41,569 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The goal of this project is to identify how an electronic patient portal (EPP) might address adolescent sexual and reproductive health (SRH) care needs and determine factors that impact acceptability and use of an EPP for SRH care. We will use qualitative methods to elicit experiences and preferences of adolescent Kaiser Permanente Washington (KPWA) members, parents of adolescent KPWA members, and primary care providers at KPWA to inform the rigorous design of an intervention to improve adolescent EPP use for SRH care. The Kaiser Permanente Washington Health Research Institute lead investigator is Annie Hoopes.

Patient Perspectives on Prescription Opioid Discontinuation: Understanding and Promotion of Safe Transitions

A 5-year, $1,999,999 grant from the Agency for Healthcare Research and Quality. Major goals: The proposed study addresses this critical gap in our understanding of patient and provider experiences, strategies, and decisions when faced with provider-initiated long-term opioid therapy (LTOT) discontinuation. The study will address these gaps by conducting in-depth, qualitative interviews with patients who have recently discontinued LTOT and providers that have discontinued LTOT to achieve the following aims: 1) To assess patient and provider experiences and needs when providers initiate discontinuation of LTOT. 2) To develop a patient decision aid to support patients when discontinuing LTOT. The Kaiser Permanente Washington Health Research Institute lead investigator is Clarissa Hsu.


March 2022

Kaiser Permanente Washington Health Research Institute recently received word of 6 new awards.

Comparative Modeling to Inform Cervical Cancer Control Policies — Moonshot Supplement

A 1-year, $13,048 grant from the National Cancer Institute. Major goals: The goal of this project is to advance the cancer care delivery field’s ability to study structural racism and discrimination and how it contributes to health inequities and disparities. The Kaiser Permanente Washington Health Research Institute lead investigator is Aruna Kamineni.

De Beaumont Foundation (dBF) — CityHealth

A 2-year, $116,763 grant from the Vose River Charitable Fund. Major goals: The major goal of this project is to understand CityHealth policy advancement, implementation, and adoption activities and outcomes. The Kaiser Permanente Washington Health Research Institute lead investigator is Erin Hertel.

Opportunities for an Electronic Patient Portal to Meet Adolescent Sexual and Reproductive Health Care Needs

A 1-year, $41,569 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The goal of this project is to identify how an electronic patient portal (EPP) might address adolescent sexual and reproductive health (SRH) care needs and determine factors that impact acceptability and use of an EPP for SRH care. We will use qualitative methods to elicit experiences and preferences of adolescent Kaiser Permanente Washington (KPWA) members, parents of adolescent KPWA members, and primary care providers at KPWA to inform the rigorous design of an intervention to improve adolescent EPP use for SRH care. The Kaiser Permanente Washington Health Research Institute lead investigator is Annie Hoopes.

Optimizing Implementation in Cancer Control (OPTICC): Advancing Health Equity through Implementation Science: Implementation Science Centers in Cancer Control (ISC3) Environmental Scan and Cross Site Collaboration Supplement

A 1-year, $68,721 grant from the National Cancer Institute. Major goals: The major goal of this project is to develop an Implementation Science Centers in Cancer Control (ISC3) common-elements dataset of publicly available outer context (social determinants) measures that may impact implementation. This dataset, which will include data on Optimizing Implementation in Cancer Control (OPTICC) Implementation Lab (I-Lab) partners’ outer contexts, can be used for further research and pilot studies on the relationship between outer contextual factors and implementation. The Kaiser Permanente Washington Health Research Institute lead investigator is Meagan Brown.

Quality Metrics in Time to Biopsy and Lung Cancer Diagnosis in Cancer Screening Population

A 2-year, $150,000 grant from the National Cancer Institute. Major goals: The primary goal of the pilot study is to develop necessary data in developing a benchmarking intervention on lung cancer screening metrics to be tested in a R01 application in National Cancer Institute Community Oncology Research Program (NCORP) sites. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Tailoring Care to Meet the Needs of Younger Latinx Adults with Newly Diagnosed Type 2 Diabetes

A 2-year, $31,672 grant from the Garfield Memorial Fund. Major goals: The major goals of this project are to: 1. develop, pilot test and evaluate a proactive, tailored intervention for younger-onset Latinx individuals with newly diagnosed type 2 diabetes at Kaiser Permanente Northern California, and 2. to collaborate with operational and clinical stakeholders at 3 Kaiser Permanente (KP) regions (KP Washington, KP Southern California, and KP Northwest) to identify barriers and facilitators to conduct a future multi-site randomized controlled trial with this population. The Kaiser Permanente Washington Health Research Institute lead investigator is Leah Tuzzio.


February 2022

Kaiser Permanente Washington Health Research Institute recently received word of 5 new awards.

A Case-Control Study to Evaluate Broad-Spectrum Antibiotic Use and High Birth Weight as Potential Risk Factors for Early-Onset Colorectal Cancer

A 3-year, $147,400 grant from the National Cancer Institute. Major goals: The goals of the study are to characterize the association between risk of early-onset colorectal cancer and:

  1. Greater exposure to broad-spectrum antibiotics
  2. High birth weight

The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

California Health Care Foundation (CHCF) — Connected Care Accelerator (CCA) 2.0

A 2-year, $283,319 grant from the California Health Care Foundation. Major goals: To evaluate the learning collaborative and related program outcomes, including whether access to telehealth has improved, whether tested interventions result in reduced disparities, and patients’ experience of telehealth. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

Improve Health, Equity, and Costs for Disadvantaged Patients with Diabetes and Other Comorbidities through Right Primary Care at the Right Time Supported by the Right Payment

A 22-month, $153,177 grant from Helmsley Charitable Trust. Major goals:

  1. Provide support and advice to Vayu Health to develop a plan for a rigorous evaluation of a comprehensive team-based approach to providing care for complex patients with diabetes in safety net clinic settings.
  2. Assist Vayu health with interpretation of preliminary data from a small 18-month pilot and assist with development of a report and/or presentation for potential future funders.
  3. Prepare a manuscript of preliminary results from first-year pilot.

The Kaiser Permanente Washington Health Research Institute lead investigator is Michael Parchman.

Public Health Institute (PHI) — Volunteers in Service to America (VISTA) Evaluation

A 6-month, $50,000 grant from the Cigna Foundation. Major goals: To assess and document the impact of the AmeriCorp Volunteers in Service to America (VISTA) program on alumni and organizations. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

Suicide Prevention Outreach Trial for Youth — Feasibility Phase

An 18-month, $773,280 grant from the Patient-Centered Outcomes Research Institute. Major goals: The goal of this study is to conduct a pragmatic trial of an intervention to reduce suicide in adolescents that is based on the approach used for adults in the SPOT trial. This 18-month project period is to prepare for the trial and conduct feasibility analyses. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold.​​​​​​


January 2022

KPWHRI recently received word of 9 new awards.

Acceptability of Using Public Records and Credit Data for Suicide Risk Prediction

A 1-year, $468,384 grant from the National Institute of Mental Health. Major goals: Our specific aim is to elicit information regarding patient preferences for the circumstances under which public records and financial data could be used to improve suicide risk prediction models. We will use a guided discrete choice analysis survey to measure patient preferences/ratings of data linking under various hypothetical scenarios as well as the potential tradeoffs patients would be willing to make to reduce suicide attempts. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold.

Financial Worry about Affording Health Care in Breast Cancer

A 4-year, $61,959 grant from the American Cancer Society. Major goals: The project addresses the lack of evidence on financial worry in cancer and will provide evidence on how measurement and treatment of financial worry can be incorporated into clinical practice and policy evaluation. We will adapt measures of worry about affording health care and financial concern, then survey women newly diagnosed with breast cancer shortly after diagnosis and again 1 year later. The Kaiser Permanente Washington Health Research Institute lead investigator is Nora Henrikson.

Innovative Methods to Reduce Racial and Ethnic Disparities in Suicide Risk Prediction

A 4-year, $1,622,626 grant from the National Institute of Mental Health. Major goals: To develop new statistical methods to reduce racial and ethnic disparities in the performance of suicide prediction models. We will define target functions for tree-based prediction models to optimize performance within racial and ethnic subgroups in the presence of differential measurement error in predictors, differential outcome misclassification, and risk modification. We will design simulation-based sample size calculation methods to evaluate whether a prediction study is able to accurately predict suicide outcomes in racial and ethnic subgroups. The Kaiser Permanente Washington Health Research Institute lead investigator is Yates Coley.

Maintenance of the Innovation Center (Year 3)

A 1-year, $17,113 grant from the U.S. Food and Drug Administration. Major goals: The major goals of this project are to identify methodological gaps and develop methods to improve the utility of the Sentinel System by developing new Sentinel analysis tools and creating new approaches to automate key epidemiologic study operations, such as chart review. The Sentinel Innovation Center (IC) Executive Leadership Team oversees all aspects of operations for the IC. The IC Executive Leadership Team has created and will maintain the organizational structure, administrative processes, and governance for the IC and its network of scientific collaborators. The IC will continue to maintain a diverse team with expertise in epidemiology, clinical medicine, pharmacy, statistics, health informatics, and data science (specifically, artificial intelligence). The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer Nelson.

Master Plan for Integration of Innovation Technologies and Innovation Center Collaboration Activities (Year 3)

A 1-year, $58,193 grant from the U.S. Food and Drug Administration (FDA). Major goals: The major goals of this project are to utilize a master plan for the prioritization, development, and incorporation of innovative technologies and new data sources into the Sentinel System to help the FDA achieve 3 key legislative mandates/strategic priorities: (1) optimizing the sufficiency of the Active Risk Identification and Analysis (ARIA) system to cost effectively use electronic health care data sources for drug safety surveillance; (2) expanding the acceptance and use of real-world data for regulatory decision making; and (3) establishing a query-ready, quality-checked distributed data network containing electronic health records on at least 10 million lives with reusable analysis tools. The Master Plan Workgroup is responsible for coordinating Innovation Center (IC) collaboration activities and establishing and maintaining the IC’s longitudinal webinar series. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer Nelson.

Public Health Institute – California Leadership Academy for Public Health (PHI – CaLAPH) Cohort 7

A 1-year, $5,000 grant from The California Wellness Foundation. Major goals: To conduct a pre-/post-assessment of California Leadership Academy for Public Health (CaLAPH) participants to assess the impact of program participation. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

Partners in Evaluation and Research (PiER) Health Disparities Community Grant Program Evaluation

A 1-year, $12,487 grant from the Colorado Department of Public Health and Environment. Major goals: The goal is to evaluate 14 coalitions working to create policy and system changes around social needs including housing and food in Colorado. We will collect data on community engagement, capacity-building efforts, and progress toward implementing changes. We will model long-term impacts on cancer, cardiovascular, and pulmonary disease. The Kaiser Permanente Washington Health Research Institute lead investigator is Elena Kuo.

Remote Monitoring to Improve Hypertension Control Among Diverse Patients

A 5-year, $348,882 grant from the National Heart, Lung, and Blood Institute. Major goals: Research Evaluation and Commercialization Hubs (REACH) will address known disparities in the prevalence and management of high blood pressure (hypertension) among racial/ethnic minorities and individuals from lower socio-economic backgrounds by combining digital health training with an enhanced digital and home monitoring intervention. The Kaiser Permanente Washington Health Research Institute lead investigator is Beverly Green.

Services to Support Studies of the Risk of New Malignancies Following Breast Cancer: Tissue Retrieval for Contralateral Breast Cancer Cases

A 1-year, $149,993 grant from the National Cancer Institute. Major goals: To examine pathological characteristics and molecular features of the index and contralateral tumors in the Kaiser Breast Cancer Survivors’ Cohort at Kaiser Permanente Washington Health Research Institute (KPWHRI). The KPWHRI lead investigator is Diana Buist.