Grants Awarded


January 2019

KPWHRI recently received word of 25 new awards.

Alliance of Randomized Trials of Medicine versus Metabolic Surgery in Type 2 Diabetes (ARMSS-T2D) Consortium

A four-year, $176,530 grant from National Institute of Diabetes and Digestive and Kidney Diseases. Major goals: To determine the long-term durability of diabetes remission after randomization to intensive medical/weight management (IMWM) or bariatric surgery; to assess the long-term (7 year) efficacy and safety of bariatric surgery compared to IMWM; and to identify clinical predictors of diabetes remission and relapse. The Kaiser Permanente Washington Health Research Institute lead investigator is David E. Arterburn.

CATALyST: Consortium for Applied Training to Advance the Learning Health System with Scholars/Trainees

A one-year, $52,902 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: We are seeking supplemental Development Fund support for our recently-funded K12 scholar program. The Kaiser Permanente Washington Health Research Institute lead investigator is Diana S. Buist.

Cooperative Pain Education and Self-Management: Expanding Treatment for Real-World Access

A two-year, $97,969 grant from National Center for Complementary and Integrative Health. Major goals: To conduct a pragmatic trial to examine the real-world effectiveness of an interactive voice response-based form of cognitive behavioral therapy for chronic pain called Cooperative Pain Education and Self Management. This trial will recruit 764 veterans (male and female) from among the Women's Health Practice Based Network sites, a network of Veteran’s Affairs (VA) health center sites. The Kaiser Permanente Washington Health Research Institute lead investigator is Lynn DeBar.

Cost of Care Conversations in Cancer Patients: Recommendations for Implementation and Training

A seven-month, $10,550 grant from Robert Wood Johnson Foundation. Major goals: To conduct secondary analysis of the findings of two Robert Wood Johnson Foundation (RWJF) Cost of Care Conversations projects, those led by Nora Henrikson and Maria Pisu. The Kaiser Permanente Washington Health Research Institute lead investigator is Nora Henrikson.

Detecting Cost-Related Cancer Treatment Conversations in the Electronic Medical Record

A one-year, $30,000 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To develop pilot data that describes the proportion of providers, patients and Electronic Medical Record (EMR) notes that have recorded cost conversations and develop an automated Natural Language Processing (NLP) algorithm capable of identifying cost-related conversations at scale. The Kaiser Permanente Washington Health Research Institute lead investigator is Kai Yeung.

Developing and Piloting Technology-Driven Shared Decision-Making for Persistent Pain Treatment in the Primary Care Setting

A one-year, $85,214 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To develop and pilot a technology-based build out of a paper-based tool that explains pain and provides a rationale for the uptake of broader non-pharmacotherapy treatment approaches. The prototype developed would serve as a foundation for a shared decision-making tool that would have both direct patient and healthcare provider interfaces to support better understanding of nonpharmacotherapy options and the motivation for their use. This project would involve a partnership with Artefact, a small technology design firm in Seattle that has experience with health-related technology tools and is well positioned to help build out and partner on usability testing on this next phase of this element of this critical tool for our overall research on promoting behavioral approaches to chronic pain management at the point of service. The Kaiser Permanente Washington Health Research Institute lead investigator is Lynn DeBar.

Exploring and Acquiring New Data Sources for Pregnancy Research

A one-year, $76,918 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To investigate, explore and acquire new data sources to support grants about medication safety in pregnancy. Two data sources to be explored including New Zealand country-wide data on pregnancy exposure and outcomes and Washington State's new "all payer" claims database which we will exploring linking with Washington state birth certificate data. We will also extract and explore KPWA's own internal data from the women's health Behavioral Health questionnaire including depression and substance use screening to understand the extent of availability and missingness of those data for pregnancies cared for within KPWA's integrated group practice. The Kaiser Permanente Washington Health Research Institute lead investigator is Sascha Dublin.

Financial Strain on Mental and Physical Health: Does Race/Ethnicity Matter?

A nine-month, $20,656 grant from National Institute on Aging. Major goals: To determine the extent to which financial stress might affect cognitive performance and function in older persons using data from the Health and Retirement Study. This is a supplement to a K award looking at other effects of financial stress. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.

Impact of Medicare Transitions in the Washington State-All-Payer-Claims Database

A one-year, $52,544 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To complete analyses begun in 2018 of the Washington All-Payer Claims Database (WA-APCD) to describe the direction and magnitude of changes in benefits and provider networks, defined using standard, and innovative methods for different sociodemographic, clinical, and insured populations. The WA-APCD contains the claims experience of 3.7 million individuals insured through the health insurance exchange, Medicaid, fully-insured employers, Medicare advantage and Medicare fee-for-service. The Kaiser Permanente Washington Health Research Institute lead investigator is Kai Yeung.

Implementation Science and Practice

A six-month, $40,000 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To generate a model, infrastructure, data structures, products, and funding streams for advancing an integrated implementation science and practice model for MacColl. The Kaiser Permanente Washington Health Research Institute lead investigator is Katie Coleman.

Improving Measures of Social Determinants of Health in the Virtual Data Warehouse (VDW) Using Census Data

A one-year, $33,102 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To calculate 6 validated social determinants of health indices for inclusion in the Virtual Data Warehouse (VDW) and to test these measures. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold. (R218167001)

Kaiser Permanente Transforming Cardiovascular Care in our Communities (TC3) Initiative Evaluation

A three-year, $250,000 grant from Kaiser Foundation Hospitals Southern California Region. Major goals: To support program improvement (formative) and evaluate success (summative) of the Transforming Cardiovascular Care in our Communities (TC3) initiative. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

Making Medical Decisions with BRCA 1/2

A one-year, $59,957 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To understand the factors important patients making decisions about their health and about family building in the context of a BRCA genetic mutation using data available on social media. This study will also explore women’s perspectives and decision making about genetic testing of embryos before implantation using social media data. This study will test the feasibility of using social media data to identify crucial gap in care for women who are BRCA1 or 2 carriers, many of whom are also women of child bearing age and provide an understanding of decision-making processes and factors related to fertility preservation and family building for women with genetic predisposition to cancer to better align care with patient preferences. The Kaiser Permanente Washington Health Research Institute lead investigator is Marlaine Gray.

Novel Computational Techniques to Detect the Relationship Between Sitting Patterns and Metabolic Syndrome in Existing Cohort Studies

A five-year, $170,689 grant from National Institute of Diabetes and Digestive and Kidney Diseases. Major goals: To use data from the Adult Changes in Thought Study to develop new machine learning methods for estimating sitting patterns from hip worn accelerometer data. The Kaiser Permanente Washington Health Research Institute lead investigator is Dori E. Rosenberg.

North Sound Accountable Community of Health (NSACH)-Eval Planning

A nine-month, $60,000 grant from North Sound ACH. Major goals: To support North Sound Accountable Community of Health (NSACH) in designing an evaluation for their transformation projects. The Kaiser Permanente Washington Health Research Institute lead investigator is Erin Hertel.

Nutrition Intervention for Weight Loss at Kaiser Permanente Washington (KPWA)

A six-month, $29,512 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To conduct an environmental scan of Kaiser Permanente (KP) regions and similar organizations (HCSRN members and VA); to establish a Kaiser Permanente Washington (KPWA) Weight Management (WM) Learning Health System (LHS) Team; to implement a small 6-month pilot of a novel, online nutritional coaching intervention with a “flexible dieting” approach (www.workingagainstgravity.com; “WAG”), and to evaluate its impact on body weight, blood pressure, fasting blood sugar, and cholesterol; and to qualitatively evaluate the experience of KPWA members with the WAG and Wellness Coaching by Phone programs. The Kaiser Permanente Washington Health Research Institute lead investigator is David E. Arterburn.

Operationalizing Behavioral Theory for Mobile Health (mHealth): Dynamics, Context, and Personalization

A four-year, $307,429 grant from Department of Health and Human Services. Major goals: To develop a framework for modeling dynamics of health behaviors in naturalistic and intervention settings, a dynamic measure of behavioral determinants from social-cognitive theory, and a dynamic version of the social-cognitive theory and validate the developed models on longitudinal physical-activity data collected through the project's year-long study. The Kaiser Permanente Washington Health Research Institute lead investigator is Predrag Klasnja.

Patient-Centered Design to Improving Lung Cancer Screening Uptake

A one-year, $85,236 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To develop lung cancer screening interventions to improve uptake and maintenance within care delivery using patient-centered and user-centered design principles. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Public Health Institute (PHI)-National Leadership Academy for the Public’s Health (NLAPH) C8

A two-year, $60,000 grant from Centers for Disease Control and Prevention. Major goals: To evaluate the 8th cohort of the National Leadership Academy for the Public's Health (NLAPH) and provide the program team with information to inform the program development. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk (Supplement)

A one-year, $54,389 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To provide supplementary support for research regarding physical activity, sedentary behavior, and venous thromboembolism risk. This project particularly supports the implementation of a case-crossover study set in Kaiser Permanente Washington, in which we will evaluate short-term risk of venous thromboembolism following physical activity. The Kaiser Permanente Washington Health Research Institute lead investigator is Laura Harrington. (R218148001)

Piloting the Implementation of Mobile Health (mHealth) for Substance Use Disorders in Primary Care

A one-year, $50,000 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To pilot the implementation of a digital treatment for substance use disorders in Kaiser Permanente primary care clinics. The Kaiser Permanente Washington Health Research Institute lead investigator is Joseph E. Glass.

Risk of New Malignancies Following Breast Cancer

A one-year, $149,828 grant from National Cancer Institute. Major goals: This retrospective population-based cohort study of women diagnosed with breast cancer will evaluate the effects of breast cancer treatments and mammographic density on risk of contralateral breast cancer (CBC), other second cancers, and cause of death. The main purpose of this study is to understand the relationship between breast cancer treatment and the occurrence of other cancers. This is a continuation study. The Kaiser Permanente Washington Health Research Institute lead investigator is Diana S. Buist.

Susceptibility Gene for Erectile Dysfunction

A six-month, $19,746 grant from National Institute of Diabetes and Digestive and Kidney Diseases. Major goals: To develop a novel framework that can be used to investigate and replicate the genetic component of Erectile Dysfunction (ED) in a highly cost-effective manner. To do this, we will expand on previous work examining genetic risk factors for ED among men with diabetes. We will perform new genome-wide association study (GWAS) to determine whether genetic risk operates through the same causal pathway as in nondiabetic men. Last, we will examine genetic predictors of disease severity, including age of onset of ED and therapeutic response. This will allow us to develop a list of candidate genes to push forward into animal models, for biomarker prediction, and for translational clinical studies of genetic ED risk factors. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.

To Model Member Choices Based on Shopping for Referred Services

A six-month, $12,842 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To model member choices based on shopping for referred services. To create a data set that will support external applications on member utilization for those high deductible health plans. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold.

Tobacco Quitline Opioid Use - MI and Navigation Intervention

A one-year, $69,455 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To conduct a survey of KP members who enrolled in the Tobacco Quitline in the past 6 months to assess their use of opioids and interest in quitting opioids. We might also ask about tobacco. The long-term goal would be to partner with Optum to do a brief motivational intervention and refer people to treatment. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer B. McClure.