Grants Awarded


March 2018

KPWHRI recently received word of nine new awards.

Analysis of Health Outcomes Utilizing a Simplified Home Phototherapy Protocol

A one-year, $45,000 grant from Kaiser Foundation Health Plan of Washington. Major goals: To document the effectiveness and safety of a simplified home phototherapy program that is being employed in some of the Kaiser Permanente Washington clinics in Western Washington. The principal investigator is Karen J. Sherman.

 

Analysis of the Risk of Motor Vehicle Accidents in Patients with Obstructive Sleep Apnea

A one-year, $436,555 grant from Jazz Pharmaceuticals. Major goals: To examine the risks associated with obstructive sleep apnea including impact on risk for motor vehicle crash, medically attended injury, cardiovascular events, and all-cause mortality. The Kaiser Permanente Washington Health Research Institute lead investigator is Sascha Dublin.

 

Breastfeeding Status at the Time of Intrauterine Device (IUD) Insertion and Postpartum Timing of IUD Insertion in Electronic Medical Record Databases

A two-year, $640,477 grant from Bayer AG. Major goals: This is a United States post marketing requirement study assessing outcomes of uterine perforation and intrauterine device (IUD) expulsion in association with breastfeeding, postpartum exposures, and type of IUD. The principal investigator is Denise M. Boudreau.

 

Causal Analyses of Nested Case-Control Studies for Comparative Effectiveness Research

A two-year, $225,852 grant from Patient-Centered Outcomes Research Institute. Major goals: TBD. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

 

Harms of Hepatocellular Carcinoma Screening in Patients with Cirrhosis

A five-year, $84,853 grant from National Cancer Institute. Major goals: To: 1) Quantify rates and identify correlates of physical harms, financial harms, and inappropriate use of screening for hepatocellular carcinoma (HCC) in persons with cirrhosis; 2) Characterize rates and identify correlates of screening-related psychological harms; and 3) Create and disseminate a balance sheet of benefits and harms to inform patients, providers, healthcare organizations, payers, and policymakers about the role of HCC screening in patients with cirrhosis. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

 

National Leadership Academy for Public Health (NLAPH) Multisector 2 (06462-01-01)

A two-year, $10,000 grant from Centers for Disease Control and Prevention. Major goals: To evaluate the results of the National Leadership Academy for the Public Health's cohort in Mississippi. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

 

Systematic Review of Social Determinants of Health Screening Tools

A one-year, $120,008 grant from Kaiser Permanente Washington Health Research Institute Development Fund. Major goals: To synthesize the current pragmatic and psychometric evidence of screening tools for social determinants of health. The principal investigator is Cara C. Lewis.

 

The University of Washington (UW) Patient Centered Outcomes Research Partnership (PCORP)

A one-year, $12,000 grant from Agency for Healthcare Research and Quality. Major goals: To provide mentoring to Patient Centered Outcomes Research Partnership (PCORP) scholar during training period. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

 

Washington State Department of Health Six Building Blocks Opioid Support

A ten-month, $26,213 grant from Centers for Disease Control and Prevention. Major goals: To provide technical assistance and support to the University of Washington and the Washington state Department of Health for implementation of the Six Building Blocks framework for safer opioid prescribing in clinics identified by the Department of Health. The Kaiser Permanente Washington Health Research Institute lead investigator is Michael L. Parchman.

 


February 2018

KPWHRI recently received word of eight new awards.

Air Pollution, the Aging Brain and Alzheimer's Disease – Supplement

A two-year, $25,953 grant from National Institute of Environmental Health Sciences. Major goals: This supplement will place air pollution monitoring devices in participants’ yards for more precise measurement and analysis. The study provides an extraordinary opportunity to develop comprehensive insights into the effects of local air pollution levels on the aging brain, including the effects of air pollution on cognition, the risk of Alzheimer’s disease and dementia, and various potential mechanisms of neurodegenerative disease and cerebrovascular disease. The Kaiser Permanente Washington Health Research Institute lead investigator is Eric B. Larson.

 

Aligning Patient and Health Plan Incentives to Improve Value in Pharmaceutical Care:  a Patient Shared Savings Model

A three-year, $503,919 grant from Laura and John Arnold Foundation. Major goals: To assess the effect of a shared savings program on patient medication utilization and patient and plan expenditures. The principal investigator is Kai Yeung.

 

Changing Narratives in Phase 1 Clinical Trial Participation

A one-year, $68,155 grant from National Science Foundation. The principal investigator is Marlaine Gray.

 

Evaluating Control of Hypertension – Effect of Social Determinants

A four-year, $96,517 grant from National Heart, Lung, and Blood Institute. Major goals: To use electronic health record data from the Accelerating Data Value Across a National Community Health Center Network (ADVANCE) clinical data research network (CDRN) of National Patient-Centered Clinical Research Network (PCORnet) from 376 Community Health Centers (CHCs) in 14 states that expanded Medicaid (n=1,139,779 patients) and 224 CHCs in 8 states that did not expand Medicaid (n=658,306 patients) to study the impact of increased health insurance on hypertension incidence, screening, treatment, and management.  The ADVANCE CDRN dataset is linked to community-level social determinants of health (SDOH), allowing us to study the interaction between SDOH, Medicaid expansion, and hypertension outcomes The Kaiser Permanente Washington Health Research Institute lead investigator is Beverly B. Green.

 

Improving Access and Reducing Burden for Patients on Specialty Drugs

A one-year, $79,642 grant from Robert Wood Johnson Foundation. Major goals: To evaluate the effect of state policies that protect patients on high cost specialty medications. We will evaluate patient and plan expenditures. The Kaiser Permanente Washington Health Research Institute lead investigator is Kai Yeung.

 

Kaiser Foundation Health Plans Mid-Atlantic States (KP MAS) - Community Ambassador Program Evaluation

A six-month, $60,000 grant from Kaiser Foundation Health Plans Mid-Atlantic States. Major goals: To evaluate the impact and sustainability of Kaiser Permanente Mid-Atlantic States’ Community Ambassador Program and to inform strategic decisions about the future of the program. The principal investigator is Maggie Jones.

 

National Leadership Academy for the Public’s Health (NLAPH) Multisector 1 (06370-01-01)

A ten-month, $10,000 grant from Centers for Disease Control and Prevention. Major goals: To evaluate cohort 7 of the National Leadership Academy for the Public's Health. The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

 

Obesity, Chemotherapy Dosing, and Breast Cancer Outcomes

A five-year, $1,254,412 grant from National Cancer Institute. Major goals: To use data on nearly 34,000 breast cancer patients from two integrated healthcare delivery systems to i) examine factors associated with chemotherapy dose reductions among obese women, ii) evaluate the mediating effect of dose reductions on the association between obesity and poor breast cancer outcomes, and iii) address whether fully dosed obese women experience excess toxicity as compared to their fully dosed non-obese counterparts. The Kaiser Permanente Washington Health Research Institute lead investigator is Erin J. Bowles


January 2018

KPWHRI recently received word of 18 new awards.

3rd Seattle Symposium on Health Care Data Analytics

A one-year, $14,000 grant from KPWHRI Development Fund. Major goals: To strengthen collaborative relationships between field-leading biostatisticians and other scientists in health care analytics, to possibly publish a supplement in a special issue of a statistical or analytics journal, and to strengthen our national reputation as a leader in methods for health care data analytics. The principal investigator is Jennifer C. Nelson.

 

A Reusable, Generalizable Method to Link Health Plan Claims Data with the National Death Index Plus to Examine the Association Between Medical Products and Death and Causes of Death

A one-year, $152,149 grant from Food and Drug Administration. Major goals: To develop a reusable, generalizable method of linking multiple health plan databases with the Centers for Disease Control and Prevention’s National Death Index Plus (NDI+) data. This will be done using the distributed data network and infrastructure of the Food and Drug Administration (FDA)’s Sentinel System. The project will focus on FDA’s need to conduct population-based, post-market assessments of death and specific causes of death as outcomes in both safety and effectiveness analyses. We will pilot the feasibility of the developed approach through a use case designed to examine the associations between select antidepressants and all-cause mortality and specific causes of death (e.g., cardiovascular death). The Kaiser Permanente Washington Health Research Institute lead investigator is Denise M. Boudreau.

 

Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE)

A three-year, $100,000 grant from Patient-Centered Outcomes Research Institute. Major goals: ADAPTABLE is a large pragmatic trial comparing low- and moderate-dose aspirin for prevention of cardiovascular events. Kaiser Permanente Washington Health Research Institute (KPWHRI) will collaborate in the independent evaluation of the ADAPTABLE trial, specifically focused on recruitment strategies, outcome ascertainment, stakeholder engagement, and governance. The Kaiser Permanente Washington Health Research Institute lead investigator is Gregory E. Simon.

 

BP-CHECK Comparative Cost Effectiveness and Automated Office Blood Pressure (BP) Measurements Pilot

A one-year, $55,988 grant from KPWHRI Development Fund. Major goals: To determine the difference between automated office Blood Pressure (BP) measurements (average of 3 measurements) compared to 24-hour ambulatory BP monitoring and to determine whether being alone in a room or having the examiner in the room makes a difference on automated office BP measurements. The principal investigator is Beverly B. Green.

 

CCALAC (Community Clinic Association of Los Angeles County) -AFS (Advancing the Financial Strength of LA Clinics Project)

A one-year, $50,000 grant from Cedars-Sinai. Major goals: TBD. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Schafer.

 

Expanding the (My Mobile Advice Program) MyMAP Mobile Health (mHealth) Intervention for Smoking Cessation

A one-year, $65,068 grant from KPWHRI Development Fund. Major goals: To expand and update the MyMAP (My Mobile Advice Program) for use with additional pharmacotherapies and patient populations. The principal investigator is Jennifer B. McClure.

 

Honoring What Matters to Patients with Multiple Chronic Conditions - Feasibility Study

A one-year, $107,409 grant from KPWHRI Development Fund. Major goals: To engage patients, family caregivers and primary and palliative care providers to establish specifications for integrating the personal values into primary care via a values-elicitation tool and clinical workflows; and test the feasibility and acceptability of using the tool and workflows for eliciting and using personal values to guide care in a pilot study of patients with multiple chronic conditions in primary care. The principal investigator is James D. Ralston.

 

Human Papillomavirus (HPV) Boost Pilot (FHCRC)

A six-month, $10,036 grant from Fred Hutchinson Cancer Research Center. Major goals: To assess the willingness of Kaiser Permanente Washington patients ages 9 to 19 years old who have received only a single dose of HPV vaccine to participate in a larger study of an HPV booster vaccine. The results of this pilot will inform study feasibility and recruitment strategies for a February 2018 grant application to National Institute of Allergy and Infectious Diseases (NIAID) which will seek to provide data to inform future HPV vaccine dosing schedules, including whether a reduced, two-dose series is sufficient for individuals aged 15-26 years. The principal investigator is Aruna Kamineni.

 

Impact of Medicare Transitions in the Washington (WA)-All Payer Claims Dataset

A one-year, $99,993 grant from KPWHRI Development Fund. Major goals: To target the gaps in our understanding about the benefits and harms of Medicare transitions by implementing methods to characterize the direction and magnitude of changes in medical and pharmacy benefits and provider networks that occur as a result of Medicare eligibility. The principal investigator is Kai Yeung.

 

Implementation of a Pragmatic Trial of Whole Health Team vs. Primary Care Group Education to Promote Non-Pharmacological Strategies to Improve Pain, Functioning, and Quality of Life in Veterans

A two-year, $17,114 grant from National Center for Complementary and Integrative Health. Major goals: To implement a new Whole Health model for chronic pain care emphasizing nondrug pain self-management that reduces pain symptoms and improves overall functioning and quality of life in veterans. This pragmatic trial will enroll over 600 veterans with moderate to severe chronic pain across multiple Veteran Affairs (VA) health care centers. The Kaiser Permanente Washington Health Research Institute lead investigator is Lynn DeBar.

 

Improving Identification of Suicide Risk via Routine Screening for Depression and Alcohol Use

A six-month, $40,048 grant from KPWHRI Development Fund. Major goals: To evaluate the association between alcohol use and suicide attempt (non-fatal and deaths); and to evaluate how different patterns of alcohol use influence the relationship between suicidal ideation and suicide attempt. This work will support development of the analytic methods to determine whether population-based alcohol and depression screening information, increasingly obtained in health systems across the U.S., can be used to better identify patients who will attempt and may die by suicide. The principal investigator is Julie E. Richards.

 

Learning Health Systems Mentored Career Development Program (K12)

A four-month, $21,723 grant from KPWHRI Development Fund. Major goals: To build a Learning Health Systems Mentored Career Development Program in collaboration with colleagues at University of Washington, Veteran’s Affairs Health Services Research and Development Service, and Washington State University. The principal investigator is Diana S. Buist.

 

Methods for Tracking Intervention Adaptation and Implementation Strategies - Part 2

A one-year, $120,008 grant from KPWHRI Development Fund. Major goals: To obtain pilot data to support an R01 application that would develop pragmatic measures and methods for tracking tailoring of implementation strategies and treatment adaptation in the context of a depression prevention implementation trial. The principal investigator is Cara C. Lewis. (R217176001)

 

(Mobile Health) mHealth in Interventions to Augment Medication Treatment of Opioid Use Disorder in Primary Care

A one-year, $83,755 grant from KPWHRI Development Fund. Major goals: To pilot the feasibility of using mHealth platforms to augment buprenorphine treatment in primary care. The principal investigator is Joseph E. Glass.

 

Project Connect

A one-year, $65,583 grant from KPWHRI Development Fund. Major goals: To understand KPWA member and clinician experiences with peer support and other systems as young patients (aged 25-45) with complex medical conditions and caregivers of young patients through survey and qualitative interviews. The principal investigator is Karen Wernli.

 

Tapering Off Opioids-Grant Proposal Development Funds

A six-month, $43,045 grant from KPWHRI Development Fund. Major goals: TBD. The principal investigator is Clarissa Hsu.

 

The California Endowment (TCE)- California Leadership Academy for the Public's Health (CaLAPH) Cohort 4

A one-year, $5,000 grant from The California Endowment. Major goals: To evaluate the 2018 cohort of the California Leadership Academy for the Public's Health (CaLAPH). The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

 

User-Centered Design of Tools for Explaining Chronic Back Pain to Patients

A six-month, $31,670 grant from KPWHRI Development Fund. Major goals: To develop a tool that can guide primary care clinicians in explaining chronic back pain and its self-management to patients. The principal investigator is Michael R. Von Korff.