Laura B. Harrington, PhD, MPH, is a cardiovascular epidemiologist and Assistant Investigator at Kaiser Permanente Washington Health Research Institute (KPWHRI) who works to improve the understanding of modifiable risk factors associated with cardiovascular event risk. In particular, her research focuses on cardiovascular risk among older women and on risk factors associated with incident and recurrent venous thromboembolism (VTE - blood clots occurring predominantly in the legs or the lungs).
VTE is the third most common cardiovascular diagnosis in the United States, yet there is more to understand about its etiology and prevention. Thus, Dr. Harrington’s work currently aims to improve health by furthering our knowledge of the etiology, prevention, and treatment of these events.
In August 2018, Dr. Harrington joined KPWHRI, where she is leading research as part of a career development award from the National Heart, Lung, and Blood Institute to evaluate the relationship between physical activity, sedentary behavior and VTE risk. She is using data from the Women’s Health Initiative, the Nurses’ Health Study, and interview data collected directly from KP Washington enrollees, to improve the understanding of how physical activity and sedentary behavior are associated with the risk of a first VTE, as well as health after someone has experienced a VTE.
Before joining KPWHRI, Dr. Harrington completed a postdoctoral fellowship in cardiovascular epidemiology in the Harvard T.H. Chan School of Public Health’s Department of Nutrition, a PhD in epidemiology at the University of Washington, and an MPH in epidemiology at the University of Michigan. She conducts epidemiologic research using a variety of data sources, including the integrated health care delivery system-based Heart and Vascular Health Study, the Women’s Health Initiative, the Cardiovascular Health Study, the Nurses’ Health Studies I and II and the Health Professionals Follow-up Study.
Risk factors for incident and recurrent venous thrombosis; pharmacologic risk factors; lifestyle-based risk factors; hormonally-related risk factors; women’s cardiovascular health
Endogenous hormones and exogenous hormone use in relation to cardiovascular health; menopausal transition; vasomotor symptoms
Long-term prognosis following cardiovascular events
Pharmacologic risk factors associated with cardiovascular outcomes
Dublin S, Walker RL, Floyd JS, Shortreed SM, Fuller S, Albertson-Junkans LH, Harrington LB, Greenwood-Hickman MA, Green BB, Psaty BM. Renin-angiotensin-aldosterone system inhibitors and COVID-19 infection or hospitalization: a cohort study. medRxiv. 2020:2020.07.06.20120386. doi: 10.1101/2020.07.06.20120386. PubMed
Hagan KA, Harrington LB, Kim J, Lindström S, Camargo CA Jr, Grodstein F, Kabrhel C. Adiposity throughout the life course and risk of venous thromboembolism. Thromb Res. 2018 Dec;172:67-73. doi: 10.1016/j.thromres.2018.10.024. Epub 2018 Oct 26. PubMed
Hagan KA, Harrington LB, Kim J, Zeleznik O, Rimm EB, Grodstein F, Kabrhel C. Reduction in physical function in women after venous thromboembolism. J Thromb Haemost. 2018 Jun 8. doi: 10.1111/jth.14196. [Epub ahead of print]. PubMed
Harrington LB, Hagan KA, Mukamal KJ, Kang JH, Kim J, Crous-Bou M, Lindström S, Rimm EB, Kabrhel C, Jensen MK. Alcohol consumption and the risk of incident pulmonary embolism in US women and men. J Thromb Haemost. 2018 Jul 5. doi: 10.1111/jth.14224. [Epub ahead of print]. PubMed
Kim J, Kraft P, Hagan KA, Harrington LB, Lindstroem S, Kabrhel C. Interaction of a genetic risk score with physical activity, physical inactivity, and body mass index in relation to venous thromboembolism risk. Genet Epidemiol. 2018 Jun;42(4):354-365. doi: 10.1002/gepi.22118. Epub 2018 Mar 8. PubMed
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