Medication Use & Patient Safety

“We can dramatically improve health care by making sure people get the right medicines at appropriate doses.”

Denise M. Boudreau, RPh, PhD
Kaiser Permanente Washington Health Research Institute Senior Investigator

Research overview

Americans are using more prescription drugs than ever. You may worry about side effects, drug interactions, and costs, especially if you use multiple medications. Kaiser Permanente Washington Health Research Institute (KPWHRI) scientists are studying the beneficial and harmful effects of medications in real-world settings such as Kaiser Permanente Washington. And they are working on ways to manage and monitor drug use better.

“We can dramatically improve health care by making sure people get the right medicines at appropriate doses,” said Denise M. Boudreau, RPh, PhD, KPWHRI senior investigator. “The Institute contributes to this effort by participating in national initiatives to monitor medication safety. At the personal level, we’re providing information to doctors and patients for weighing the risks and benefits of various prescription drugs.”

Funders of KPWHRI medication use and patient safety research include the Centers for Disease Control and Prevention (CDC), the U.S. Food and Drug Administration (FDA), the Patient-Centered Outcomes Research Institute (PCORI), the Group Health Foundation, and other sources. Projects include:

  • Developing and evaluating a primary care program for safe use of prescription opioids commonly used for pain, such as Oxycontin and Vicodin;
  • Studying the safety of cardiovascular medications, including in older adults;
  • Proactive monitoring of medical products through the FDA Sentinel Initiative;
  • Exploring how genetics might personalize treatments;
  • Studying medication safety during pregnancy;
  • Investigating how medications affect risk of cognitive decline and dementia in late life; and
  • Monitoring vaccine safety and effectiveness.

“Our work gives patients and providers evidence about the outcomes of medication use—both harmful and beneficial—to help them make informed personal decisions about prescription drug use,” said Associate Investigator Sascha Dublin, MD, PhD.

Recent publications on Medication Use & Patient Safety

Casillas A, Moreno G, Grotts J, Tseng CH, Morales LS. A digital language divide? the relationship between internet medication refills and medication adherence among limited English proficient (LEP) patients. J Racial Ethn Health Disparities. 2018 Mar 29. pii: 10.1007/s40615-018-0487-9. doi: 10.1007/s40615-018-0487-9. [Epub ahead of print]. PubMed

Dublin S, Von Korff M. Prescription Opioids and Infection Risk: Research and Caution Needed. Ann Intern Med. 2018;168(6):444-445. doi: 10.7326/M18-0001. Epub 2018 Feb 13. PubMed

Martin D, Gagne JJ, Gruber S, Izem R, Nelson JC, Nguyen MD, Ouellet-Hellstrom R, Schneeweiss S, Toh S, Walker AM. Sequential surveillance for drug safety in a regulatory environment. Pharmacoepidemiol Drug Saf. 2018 Mar 5. doi: 10.1002/pds.4407. [Epub ahead of print]. PubMed

Thakral M, Walker RL, Saunders K, Shortreed SM, Dublin S, Parchman M, Hansen RN, Ludman E, Sherman KJ, Von Korff M. Impact of opioid dose reduction initiatives on chronic opioid therapy patients at higher risk for opioid-related adverse outcomes. Pain Med. 2017 Dec 6. doi: 10.1093/pm/pnx293. [Epub ahead of print]. PubMed

Gray SL, Walker RL, Dublin S, Yu O, Bowles EJA, Anderson ML, Crane PK, Larson EB. Proton pump inhibitor use and dementia risk: prospective population-based study. J Am Geriatr Soc. 2017 Nov 14. doi: 10.1111/jgs.15073. [Epub ahead of print]. PubMed

Researchers in Medication Use & Patient Safety

Jennifer C. Nelson, PhD

Director of Biostatistics; Senior Investigator
206-287-2004
nelson.jl@ghc.org

Curriculum vitae (CV)

Denise M. Boudreau, PhD

Sr Investigator, Kaiser Permanente Washington Health Research Institute
206-287-2067
boudreau.d@ghc.org

Curriculum vitae (CV)

Andrea J. Cook, PhD

Senior Investigator
206-287-4257
cook.aj@ghc.org

Curriculum vitae (CV)

Sascha Dublin, MD, PhD

Associate Investigator
206-287-2870
dublin.s@ghc.org

Curriculum vitae (CV)

Michael L. Jackson, PhD, MPH

Associate Investigator
206-287-2220
jackson.ml@ghc.org

Curriculum vitae (CV)

Andrea Z. LaCroix, PhD

Senior Investigator
858-822-1073
Alacroix@ucsd.edu

Curriculum vitae (CV)

Eric B. Larson, MD, MPH, MACP

Vice President for Research and Health Care Innovation, Kaiser Foundation Health Plan of Washington; Executive Director & Senior Investigator, Kaiser Permanente Washington Health Research Institute
206-287-2988
larson.e@ghc.org

Curriculum vitae (CV)

Diana L. Miglioretti, PhD

Senior Investigator

Curriculum vitae (CV)

Bruce M. Psaty, MD, PhD

Senior Investigator
206-543-0710
psaty@u.washington.edu

Curriculum vitae (CV)

David E. Arterburn, MD, MPH

Sr Investigator, Kaiser Permanente Washington Health Research Institute; Physician, Washington Permanente Medicial Group, Internal Medicine
206-287-4610
arterburn.d@ghc.org

Curriculum vitae (CV)

Jessica Chubak, PhD, MBHL

Associate Investigator
206-287-2556
chubak.j@ghc.org

Curriculum vitae (CV)

Susan M. Shortreed, PhD

Associate Investigator
206-287-2088
shortreed.s@ghc.org

Curriculum vitae (CV)

Karen Wernli, PhD

Associate Investigator
206-287-2934
wernli.k@ghc.org

Curriculum vitae (CV)

Ellen O'Meara, PhD

Research Associate
206-287-2938
omeara.e@ghc.org

Curriculum vitae (CV)

Onchee Yu, MS

Senior Biostatistician
206-287-2389
yu.o@ghc.org

Curriculum vitae (CV)

Rod L. Walker, MS

Biostatistician
206-287-2895
walker.rl@ghc.org

Curriculum vitae (CV)

Robert D. Wellman, MS

Biostatistician
206-287-2557
wellman.r@ghc.org

Curriculum vitae (CV)

Gaia Pocobelli, PhD

Research Associate
287-2914
pocobelli.g@ghc.org

Curriculum vitae (CV)

David S. Carrell, PhD

Assistant Investigator
206-287-2705
carrell.d@ghc.org

Curriculum vitae (CV)

Lu Chen, PhD, MPH

Research Associate
206-287-2024
chen.l@ghc.org

Curriculum vitae (CV)

Affiliate researchers

Susan Heckbert, MD, PhD
University of Washington (UW) Department of Epidemiology; UW Cardiovascular Health Research Unit

David Siscovick, MD, MPH
UW Department of Medicine; UW Department of Epidemiology; UW Cardiovascular Health Research Unit

Leslie Spangler, PhD
Amgen