Diana L. Miglioretti, PhD

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“My research is about the risks and benefits of procedures such as cancer screening. I'm working to standardize medical imaging so patients can be confident they're getting the lowest radiation doses necessary for effective imaging.”

Diana L. Miglioretti, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute
Dean’s Professor of Biostatistics, University of California, Davis

(530) 752-7168

Twitter: @dmiglio

Biography

Senior investigator and professor of biostatistics Diana Miglioretti, PhD, is committed to improving health care by building the evidence base for personalized cancer screening. To achieve this goal, Dr. Miglioretti pursues a rigorous combination of applied and methodological research. Her work focuses on the benefits and risks of cancer screening and appropriate use of screening and diagnostic tools including medical imaging.

Dr. Miglioretti co-leads the Breast Cancer Surveillance Consortium (BCSC)—a network of breast imaging registries that has the largest and most comprehensive collection of breast cancer screening data in the nation. Established in 1994, the BCSC is currently supported by a $17 million program project grant from the National Cancer Institute. The vast BCSC database includes information on about 12 million film, digital, and 3D mammograms for more than 2.4 million women. The BCSC also has extensive data on newer methods such as digital breast tomosynthesis (also called 3D mammography) and breast MRI (magnetic resonance imaging).

Dr. Miglioretti’s expertise in maximizing the value of the BCSC data includes establishing and evaluating data collection, helping individual sites and outside researchers with analyses, and developing new statistical techniques. In part through her efforts, results from BCSC studies have helped guide national breast cancer screening policy decisions and clinical guidelines. A few examples of Dr. Miglioretti’s BCSC studies are:

Other examples of Dr. Miglioretti’s research include:

In addition to her KPWHRI faculty position, Dr. Miglioretti is the Dean’s Professor of Biostatistics in the Department of Public Health Sciences, School of Medicine, University of California, Davis. She enthusiastically shares her expertise as an instructor at the Radiological Society of North America's (RSNA) annual workshop in clinical trials methodology, which prepares radiologists to develop clinical research protocols and apply for funding.

Among Dr. Miglioretti’s professional memberships are the American Association for Cancer Research, the International Biometrics Society Eastern and Western North America regions, and the American Statistical Association, for which she was elected a fellow.

Research interests and experience

  • Biostatistics

    Clustered and longitudinal data analysis; latent variable modeling; assessment of diagnostic and screening tests

  • Cancer

    Biostatistics; breast cancer screening and  surveillance; mammographic breast density; risk prediction

  • Radiology

    Imaging trends; radiation exposure from medical  imaging; evaluation of imaging tests

  • Screening

 

Recent publications

Demb J, Chu P, Yu S, Whitebird R, Solberg L, Miglioretti DL, Smith-Bindman R. Analysis of computed tomography radiation doses used for lung cancer screening scans.  JAMA Intern Med. 2019 Sep 23. doi: 10.1001/jamainternmed.2019.3893. [Epub ahead of print]. PubMed

Reed SC, Bell JF, Miglioretti DL, Nekhlyudov L, Fairman N, Joseph JG. Fear of cancer recurrence and associations with mental health status and individual characteristics among cancer survivors:findings from a nationally representative sample. J Psychosoc Oncol. 2019 Sep 11:1-18. doi: 10.1080/07347332.2019.1649338. [Epub ahead of print]. PubMed

Lowry KP, Trentham-Dietz A, Schechter CB, Alagoz O, Barlow WE, Burnside ES, Conant EF, Hampton JM, Huang H, Kerlikowske K, Lee SJ, Miglioretti DL, Sprague BL, Tosteson ANA, Yaffe M, Stout NK. Long-term outcomes and cost-effectiveness of breast cancer screening with digital breast tomosynthesis in the United States. J Natl Cancer Inst. 2019 Sep 10. pii: 5567105. doi: 10.1093/jnci/djz184. [Epub ahead of print]. PubMed

Smith-Bindman R, Kwan ML, Marlow EC, Theis MK, Bolch W, Cheng SY, Bowles EJA, Duncan JR, Greenlee RT, Kushi LH, Pole JD, Rahm AK, Stout NK, Weinmann S, Miglioretti DL. Trends in use of medical imaging in US health care systems and in Ontario, Canada, 2000-2016. JAMA. 2019;322(9):843-856. doi: 10.1001/jama.2019.11456. PubMed

Henderson LM, Ichikawa L, Buist DSM, Lee JM, Bush M, Johnson D, Onega T, Nekhlyudov L, Kerlikowske K, Miglioretti DL, Sprague BL, Wernli KJ. Patterns of breast imaging use among women with a personal history of breast cancer. J Gen Intern Med. 2019 Aug 13. doi: 10.1007/s11606-019-05181-6. [Epub ahead of print].

Lesser RP, Webber WRS, Miglioretti DL, Pillai JJ, Agarwal S, Mori S, Morrison PF, Castagnola S, Lawal A, Lesser HJ. Cognitive effort decreases beta, alpha, and theta coherence and ends afterdischarges in human brain. Clin Neurophysiol. 2019 Jul 19. pii: S1388-2457(19)31150-2. doi: 10.1016/j.clinph.2019.07.007. [Epub ahead of print]. PubMed

Gould MK, Smith-Bindman R, Kelly K, Altman DE, Barjaktarevic I, Creekmur B, de Bie E, Dyer DS, Mortani Barbosa EJ Jr, Mularski RA, Qi L, Vaszar LT, Yu S, Miglioretti DL. Methods for the Watch the Spot Trial: a pragmatic trial of more vs. less intensive strategies for active surveillance of small pulmonary nodules. Ann Am Thorac Soc. 2019 Jul 17. doi: 10.1513/AnnalsATS.201903-268SD. [Epub ahead of print]. PubMed

Wernli KJ, Brandzel SD, Buist DM, Bush M, DeMartini W, Ichikawa L, Haas C, Henderson LM, Johnson D, Kerlikowske K, McColgin D, Miglioretti DL, Nekhlyudov L, Onega T, Rosenberg DE. Is breast MRI better at finding second breast cancers than mammograms alone for breast cancer survivors? Washington, DC: Patient-Centered Outcomes Research Institute (PCORI). 2019. https://doi.org/10.25302/5.2019.CE.13046656.

Kwan ML, Miglioretti DL, Marlow EC, Aiello Bowles EJ, Weinmann S, Cheng SY, Deosaransingh KA, Chavan P, Moy LM, Bolch WE, Duncan JR, Greenlee RT, Kushi LH, Pole JD, Rahm AK, Stout NK, Smith-Bindman R. Trends in medical imaging during pregnancy in the United States and Ontario, Canada, 1996 to 2016. JAMA Netw Open. 2019;2(7):e197249. doi: 10.1001/jamanetworkopen.2019.7249. PubMed

Kerlikowske K, Miglioretti DL, Vachon CM. Breast density information for primary care providers to facilitate discussions of dense breasts, breast cancer risk and screening choices in 2019. JAMA. 2019 Jul 2;322(1):69-70. doi: 10.1001/jama.2019.6247. PubMed

 

cancer research

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Using breast MRI after cancer may lead to unneeded biopsies

A Kaiser Permanente-led BCSC study is among the largest ever to evaluate adding MRI surveillance for breast cancer survivors.

Researcher profile

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Why does Diana Miglioretti study the biostatistics of cancer screening?

Family history sparks interest for KPWHRI senior investigator, UC Davis professor, and co-leader of the BCSC.

Read it in News and Events.

women's health

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Study shows benefits of 3D mammography

Digital breast tomosynthesis reduced patient recalls with no change in cancer detection, study shows.

study results

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No need to follow up simple ovarian cysts

New KPWHRI study shows that women with simple cysts are not at increased risk of ovarian cancer.

kpwhri in the media

study findings

No need to follow up simple ovarian cysts

NIH Research Matters Newsletter, Dec 4, 2018