Senior investigator and professor of biostatistics Diana Miglioretti, PhD, is committed to improving health care by building the evidence base for personalized cancer screening. To achieve this goal, Dr. Miglioretti pursues a rigorous combination of applied and methodological research. Her work focuses on the benefits and risks of cancer screening and appropriate use of screening and diagnostic tools including medical imaging.
Dr. Miglioretti co-leads the Breast Cancer Surveillance Consortium (BCSC)—a network of breast imaging registries that has the largest and most comprehensive collection of breast cancer screening data in the nation. Established in 1994, the BCSC is currently supported by a $17 million program project grant from the National Cancer Institute. The vast BCSC database includes information on about 12 million film, digital, and 3D mammograms for more than 2.4 million women. The BCSC also has extensive data on newer methods such as digital breast tomosynthesis (also called 3D mammography) and breast MRI (magnetic resonance imaging).
Dr. Miglioretti’s expertise in maximizing the value of the BCSC data includes establishing and evaluating data collection, helping individual sites and outside researchers with analyses, and developing new statistical techniques. In part through her efforts, results from BCSC studies have helped guide national breast cancer screening policy decisions and clinical guidelines. A few examples of Dr. Miglioretti’s BCSC studies are:
Other examples of Dr. Miglioretti’s research include:
In addition to her KPWHRI faculty position, Dr. Miglioretti is the Dean’s Professor of Biostatistics in the Department of Public Health Sciences, School of Medicine, University of California, Davis. She enthusiastically shares her expertise as an instructor at the Radiological Society of North America's (RSNA) annual workshop in clinical trials methodology, which prepares radiologists to develop clinical research protocols and apply for funding.
Among Dr. Miglioretti’s professional memberships are the American Association for Cancer Research, the International Biometrics Society Eastern and Western North America regions, and the American Statistical Association, for which she was elected a fellow.
Clustered and longitudinal data analysis; latent variable modeling; assessment of diagnostic and screening tests
Biostatistics; breast cancer screening and surveillance; mammographic breast density; risk prediction
Imaging trends; radiation exposure from medical imaging; evaluation of imaging tests
Wernli KJ, Brandzel SD, Buist DM, Bush M, DeMartini W, Ichikawa L, Haas C, Henderson LM, Johnson D, Kerlikowske K, McColgin D, Miglioretti DL, Nekhlyudov L, Onega T, Rosenberg DE. Is breast MRI better at finding second breast cancers than mammograms alone for breast cancer survivors? Washington, DC: Patient-Centered Outcomes Research Institute (PCORI). 2019. https://doi.org/10.25302/5.2019.CE.13046656.
Engmann NJ, Scott C, Jensen MR, Winham SJ, Ma L, Brandt KR, Mahmoudzadeh A, Whaley DH, Hruska CB, Wu FF, Norman AD, Hiatt RA, Heine J, Shepherd J, Pankratz VS, Miglioretti DL, Kerlikowski K, Vachon CM. Longitudinal changes in volumetric breast density in healthy women across the menopausal transition. Cancer Epidemiol Biomarkers Prev. 2019 Jun 11. pii: 1055-9965.EPI-18-1375. doi: 10.1158/1055-9965.EPI-18-1375. [Epub ahead of print]. PubMed
Kerlikowske K, Miglioretti DL, Vachon CM. Discussions of dense breasts, breast cancer risk, and screening choices in 2019. JAMA. 2019 May 31. pii: 2735405. doi: 10.1001/jama.2019.6247. [Epub ahead of print]. PubMed
Engmann NJ, Scott CG, Jensen MR, Winham S, Miglioretti DL, Ma L, Brandt K, Mahmoudzadeh A, Whaley DH, Hruska C, Wu F, Norman AD, Hiatt RA, Heine J, Shepherd J, Pankratz VS, Vachon CM, Kerlikowske K. Combined effect of volumetric breast density and body mass index on breast cancer risk. Breast Cancer Res Treat. 2019 May 25. pii: 10.1007/s10549-019-05283-z. doi: 10.1007/s10549-019-05283-z. [Epub ahead of print]. PubMed
Miglioretti DL, Abraham L, Lee CI, Buist DSM, Herschorn SD, Sprague BL, Henderson LM, Tosteson ANA, Kerlikowske K. Digital breast tomosynthesis: radiologist learning curve. Radiology. 2019;291(1):34-42. doi: 10.1148/radiol.2019182305. Epub 2019 Feb 26. PubMed
Doria-Rose VP, Greenlee RT, Buist DSM, Miglioretti DL, Corley DA, Brown JS, Clancy HA, Tuzzio L, Moy LM, Hornbrook MC, Brown ML, Ritzwoller DP, Kushi LH, Greene SM. Collaborating on data, science, and infrastructure: the 20-year journey of the Cancer Research Network. eGEMS (Wash DC). 2019;7(1):7. doi: 10.5334/egems.273. PubMed
Lee JM, Arao RF, Sprague BL, Kerlikowske K, Lehman CD, Smith RA, Henderson LM, Rauscher GH, Miglioretti DL. Performance of screening ultrasonography as an adjunct to screening mammography in women across the spectrum of breast cancer risk. JAMA Intern Med. 2019 Mar 18. doi: 10.1001/jamainternmed.2018.8372. [Epub ahead of print]. PubMed
Reed SC, Bell JF, Miglioretti DL, Nekhlyudov L, Fairman N, Joseph JG. Relationships between fear of cancer recurrence and lifestyle factors among cancer survivors. J Cancer Educ. 2019 Mar 16. pii: 10.1007/s13187-019-01509-2. doi: 10.1007/s13187-019-01509-2. [Epub ahead of print]. PubMed
Tice JA, Bissell MCS, Miglioretti DL, Gard CC, Rauscher GH, Dabbous FM, Kerlikowske K. Validation of the breast cancer surveillance consortium model of breast cancer risk. LID - 10.1007/s10549-019-05167-2 [doi] Breast Cancer Res Treat. 2019 Feb 22. pii: 10.1007/s10549-019-05167-2. doi: 10.1007/s10549-019-05167-2 [Epub ahead of print] PubMed
Miglioretti DL, Lee JM, Kerlikowske K. Re: "Linkage of the ACR National Mammography Database to the network of state cancer registries: proof of concept evaluation by the ACR National Mammography Database Committee". J Am Coll Radiol. 2019;16(2):135-136. doi: 10.1016/j.jacr.2018.09.056. PubMed
A Kaiser Permanente-led BCSC study is among the largest ever to evaluate adding MRI surveillance for breast cancer survivors.
Family history sparks interest for KPWHRI senior investigator, UC Davis professor, and co-leader of the BCSC.
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Digital breast tomosynthesis reduced patient recalls with no change in cancer detection, study shows.
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NIH Research Matters Newsletter, Dec 4, 2018