Susan Shortreed, PhD

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“By using rich data sources such as electronic health records, we can begin to identify which treatments will work best for which people.”

Susan M. Shortreed, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute

Biography

Susan Shortreed, PhD, uses statistics and machine learning methods to address health science problems, with a special emphasis on analyzing complex longitudinal data. She develops and evaluates statistical approaches for observational data, and works to improve the design and analyses of studies that use data collected from electronic health care records. She is leading a project to develop statistical methods for constructing personalized treatment strategies using data captured from electronic health records.

Dr. Shortreed earned her PhD in statistics from the University of Washington. Then she spent two years in the Department of Epidemiology and Preventive Medicine at Monash University in Melbourne, Australia, and two years in the School of Computer Science at McGill University in Montreal, Canada. Dr. Shortreed has collaborated with scientists in a broad range of areas including alcohol use, cancer screening, and medication safety. She now works alongside researchers in mental and behavioral health, evaluating and comparing treatments for chronic pain and depression, and interventions to prevent suicide. Dr. Shortreed is an investigator with the Mental Health Research Network, designing studies to address important public health concerns, such as determining which antidepressant medications work best for which patients and developing risk prediction algorithms to identify individuals who may be at increased risk for suicidal behavior.

Dr. Shortreed is also an affiliate associate professor of biostatistics at the University of Washington School of Public Health. She served on the executive board for the American Statistical Association’s Section on Statistics in Epidemiology and the editorial board of the Journal of the Royal Statistical Society, Series C: Applied Statistics.

Research interests and experience

  • Biostatistics

    Design and analysis of studies that use data collected from electronic health records; analysis of complex longitudinal data; methods for constructing personalized treatment strategies, computational statistics and algorithms; machine learning; variable selection methods.

    Medication Use & Patient Safety

    Biostatistics; machine learning; using data collected from electronic health records to study rare adverse events; opioid safety; medication safety in pregnancy.

  • Mental Health

    Biostatistics; treatment for chronic depression; suicide prevention; developing personalized treatment strategies; developing risk prediction models.

Recent publications

Coley RY, Johnson E, Simon GE, Cruz M, Shortreed SM. Racial/ethnic disparities in the performance of prediction models for death by suicide after mental health visits. JAMA Psychiatry. 2021 Apr 28:e210493. doi: 10.1001/jamapsychiatry.2021.0493. [Epub ahead of print]. PubMed

Simon GE, Matarazzo BB, Walsh CG, Smoller JW, Boudreaux ED, Yarborough BJH, Shortreed SM, Coley RY, Ahmedani BK, Doshi RP, Harris LI, Schoenbaum M. Reconciling statistical and clinicians' predictions of suicide risk. Psychiatr Serv. 2021 Mar 11:appips202000214. doi: 10.1176/appi.ps.202000214. [Epub ahead of print]. PubMed

Coulombe J, Moodie EEM, Shortreed SM, Renoux C. Can the risk of severe depression-related outcomes be reduced by tailoring the antidepressant therapy to patient characteristics? Am J Epidemiol. 2020 Dec 9:kwaa260. doi: 10.1093/aje/kwaa260. [Epub ahead of print]. PubMed

Coulombe J, Moodie EEM, Shortreed SM, Renoux C. Response to: baby steps to a learning mental health care system: can we do the work? Am J Epidemiol. 2020 Dec 9:kwaa262. doi: 10.1093/aje/kwaa262. [Epub ahead of print]. PubMed

Dublin S, Walker R, Floyd JS, Shortreed SM, Fuller S, Albertson-Junkans L, Harrington LB, Greenwood-Hickman MA, Green BB, Psaty BM. Renin-angiotensin-aldosterone system inhibitors and COVID-19 infection or hospitalization: a cohort study. Am J Hypertens. 2021 Apr 20;34(4):339-347. doi: 10.1093/ajh/hpaa168. PubMed

Shortreed SM, Moodie EEM. Automated analyses: because we can, does it mean we should? Stat Sci. 2020 Aug;35(3):499-502. doi: 10.1214/20-sts773. Epub 2020 Sep 11. PubMed

Zheng Y, Corley DA, Doubeni C, Halm E, Shortreed SM, Barlow WE, Zauber A, Tosteson TD, Chubak J. Analyses of preventive care measures with incomplete historical data in electronic medical records: an example from colorectal cancer screening. Ann Appl Stat.14(2), 1030-1044. https://doi.org/10.1214/20-AOAS1342.

Dublin S, Walker RL, Floyd JS, Shortreed SM, Fuller S, Albertson-Junkans LH, Harrington LB, Greenwood-Hickman MA, Green BB, Psaty BM. Renin-angiotensin-aldosterone system inhibitors and COVID-19 infection or hospitalization: a cohort study. medRxiv. 2020:2020.07.06.20120386. doi: 10.1101/2020.07.06.20120386. PubMed

Shortreed SM, Simon GE. Using predictive analytics to improve pragmatic trial design. Clin Trials. 2020 Aug;17(4):394-401. doi: 10.1177/1740774520910367. Epub 2020 Mar 10. PubMed

Richards JE, Shortreed SM, Simon GE, Penfold RB, Glass JE, Ziebell R, Williams EC. Association between patterns of alcohol use and short-term risk of suicide attempt among patients with and without reported suicidal ideation. J Addict Med. 2020 Mar 5. doi: 10.1097/ADM.0000000000000637. [Epub ahead of print]. PubMed

 

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