Cardiovascular Health

“One in four deaths in the United States is attributed to heart disease. Our researchers study how behavior, environment, and genetics affect heart health and how screening and treatment can reduce risk.”

Laura B. Harrington, PhD, MPH
Kaiser Permanente Washington Health Research Institute Assistant Investigator

Research overview

Heart disease is the leading cause of death for Americans. Kaiser Permanente Washington Health Research Institute (KPWHRI) scientists are working to understand how to reduce our risk of heart attacks, stroke, irregular heartbeats, deep-vein blood clots, and other cardiovascular diseases.

“We’re studying how genes, medications, and everyday choices influence cardiovascular health,” says  Bruce M. Psaty, MD, PhD, KPWHRI senior investigator and co-director of the University of Washington Cardiovascular Health Research Unit. “One of our goals is to know when people are especially susceptible to either the benefits or risks of a drug, so they receive the safest and most effective therapies."

Beverly B. Green, MD, MPH, senior investigator, is finding simple, practical, innovative ways to help people control their blood pressure. “We’ve found that helping patients and health care teams work together on personalized care plans is the best path to lifelong heart health,” she says.

Kaiser Permanente Washington cardiovascular research includes studies by:

Recent publications on Cardiovascular Health

Cheadle A, Rosaschi M, Burden D, Ferguson M, Greaves B, Houston L, McClendon J, Minkoff J, Jones M, Schwartz P, Nudelman J, Maddux-Gonzalez M. A community-wide collaboration to reduce cardiovascular disease risk: the Hearts of Sonoma County initiative. Prev Chronic Dis. 2019;16:E89. doi: 10.5888/pcd16.180596. PubMed

Lemaitre RN, Jensen PN, Hoofnagle A, McKnight B, Fretts AM, King IB, Siscovick DS, Psaty BM, Heckbert SR, Mozaffarian D, Sotoodehnia N. Plasma ceramides and sphingomyelins in relation to heart failure risk. Circ Heart Fail. 2019 Jul;12(7):e005708. doi: 10.1161/CIRCHEARTFAILURE.118.005708. Epub 2019 Jul 12. PubMed

Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, Ahmed A, Liu X, Hallberg P, Yue QY, Magnusson PKE, Brisson D, Wiggins KL, Morrison AC, Khoury E, McKeigue P, Stricker BH, Lapeyre-Mestre M, Heckbert SR, Gallagher AM, Chinoy H, Gibbs RA, Bondon-Guitton E, Tracy R, Boerwinkle E, Gaudet D, Conforti A, van Staa T, Sitlani CM, Rice KM, Maitland-van der Zee AH, Wadelius M, Morris AP, Pirmohamed M, Palmer CAN, Psaty BM, Alfirevic A; PREDICTION-ADR Consortium and EUDRAGENE. Pharmacogenomics of statin-related myopathy: meta-analysis of rare variants from whole-exome sequencing. PLoS One. 2019 Jun 26;14(6):e0218115. doi: 10.1371/journal.pone.0218115. eCollection 2019. PubMed

Carr DF, Francis B, Jorgensen AL, Zhang E, Chinoy H, Heckbert SR, Bis JC, Brody JA, Floyd J, Psaty BM, Molokhia M, Lapeyre-Mestre M, Conforti A, Alfirevic A, van Staa T, Pirmohamed M. Genome-wide association study of statin-induced myopathy in patients recruited using the UK Clinical Practice Research Datalink. Clin Pharmacol Ther. 2019 Jun 20. doi: 10.1002/cpt.1557. [Epub ahead of print]. PubMed

Dashti HS, Merino J, Lane JM, Song Y, Smith CE, Tanaka T, McKeown NM, Tucker C, Sun D, Bartz TM, Li-Gao R, Nisa H, Reutrakul S, Lemaitre RN, Alshehri TM, de Mutsert R, Bazzano L, Qi L, Knutson KL, Psaty BM, Mook-Kanamori DO, Perica VB, Neuhouser ML, Scheer FAJL, Rutter MK, Garaulet M, Saxena R. Genome-wide association study of breakfast skipping links clock regulation with food timing. Am J Clin Nutr. 2019 Jun 13. pii: 5514151. doi: 10.1093/ajcn/nqz076. [Epub ahead of print]. PubMed

Researchers in Cardiovascular Health

Sascha Dublin, MD, PhD

Senior Investigator
206-287-2870
Sascha.Dublin@kp.org

Curriculum vitae (CV)

Beverly B. Green, MD, MPH

Senior Investigator
206-287-2997
Bev.B.Green@kp.org

Curriculum vitae (CV)

Laura Harrington, PhD, MPH

Assistant Investigator
206-287-2066
Laura.B.Harrington@kp.org

Curriculum vitae (CV)

Aruna Kamineni, PhD, MPH

Assistant Investigator
206-287-2922
Aruna.S.Kamineni@kp.org

Curriculum vitae (CV)

Ellen O'Meara, PhD

Research Associate
206-287-2938
Ellen.S.O'Meara@kp.org

Curriculum vitae (CV)

Jennifer C. Nelson, PhD

Director of Biostatistics; Senior Investigator
206-287-2004
Jen.Nelson@kp.org

Curriculum vitae (CV)

Michael L. Parchman, MD, MPH

Senior Investigator, MacColl Center for Health Care Innovation
206-287-2704
Michael.X.Parchman@kp.org

Curriculum vitae (CV)

Bruce M. Psaty, MD, PhD

Senior Investigator, KPWHRI; Professor of Medicine, Epidemiology, and Health Services, University of Washington
206-221-7775
psaty@uw.edu

Curriculum vitae (CV)

Affiliate researchers

James Floyd, MD, MS
Assistant Professor, Department of Medicine
Adjunct Assistant Professor, Department of Epidemiology
University of Washington

Susan Heckbert, MD, PhD
University of Washington (UW) Department of Epidemiology; UW Cardiovascular Health Research Unit

Nicholas L. Smith, PhD, MPH
UW Professor, Epidemiology, Cardiovascular Health Research Unit
Director, Seattle Epidemiology and Information Resource Center, VA Puget Sound Health Care System