Research on health informatics at Kaiser Permanente Washington focuses on developing and using health information technology (IT) to transform health care delivery. By testing new paradigms of care that provide more opportunities to engage patients, this research is supplying valuable evidence that is helping shape federal policy and guiding innovative redesign of health care.
“We’re working to understand how to make health IT practical so patients and care teams find it useful and engaging,” explained Kaiser Permanente Washington Health Research Institute (KPWHRI) Senior Investigator James Ralston, MD, MPH. “We want to find ways to use information technologies to support patients and providers together, both inside and outside the office.”
Integral to this support is designing technologies that are user-friendly and meet the needs of both patients and providers. By applying human-centered methods that focus on needs, use, and usability, KPWHRI researchers inform the design of health IT with direct participation from users.
Groundbreaking methodological work by KPWHRI health informatics researchers includes developing natural language processing (NLP) to analyze text such as notes and written reports in electronic health records (EHRs). Assistant Investigator David Carrell, PhD, leads in the area of using NLP and machine learning to identify patient phenotypes, or specific health characteristics such as possible heart disease, risk of opioid overdose, or suggestion of colon cancer. This information can assist researchers in studying how genetics and other factors influence disease.
Other examples of KPWHRI health informatics research include projects using EHRs and secure electronic communications such as:
Examples of KPWHRI research in mobile health (mHealth) and user-centered design include:
“Our studies on using health IT to improve care are showing that we can achieve better outcomes when we shift care from the doctor’s office to where people live: in their homes—and online,” said Senior Investigator Beverly B. Green, MD, MPH.
Jones SMW, Aoki RF, Alexeeff SE, Carrell D, Cronkite D, Kushi LH, Mosen D, Strayhorn S, Tuzzio L, Mogk J, Mammini L, Kroenke CH Evaluation of the Electronic Health Record-Support Social Support Score in Breast Cancer: Comparison of Count and Item Response Theory Scores 2025 Oct 6 doi: 10.1177/19427891251383539. Epub 2025-10-06. PubMed
Hoopes AJ, Metje A, Miller C, Tomlinson CM, Dao TD, Gray MF "Really hard to navigate": A qualitative study of motivators, barriers, and supports of adolescent-clinician communication on patient portals 2025 Oct;38(5):554-561. doi: 10.1016/j.jpag.2025.03.007. Epub 2025-04-04. PubMed
Stewart CC, Simon G, Ahmedani BK, Beck A, Daida YG, Lynch FL, Owen-Smith AA, Negriff SL, Rossom R, Sterling SA, Lu CY, Schoenbaum M Variation in completeness of coding external cause of injuries under ICD-10-CM 2025 Sep 23;31(5):412-415 doi:10.1136/ip-2023-045164. doi: 10.1136/ip-2023-045164. Epub 2024-06-21. PubMed
Thaweethai T, Mukherjee R, Arterburn D, Fischer H, Lee C, Shortreed SM, Haneuse S Adjusting for Selection Bias Due to Missing Data in Electronic Health Records-Based Research by Blending Multiple Imputation and Inverse Probability Weighting 2025 Jul;44(15-17):e70151. doi: 10.1002/sim.70151. PubMed
Simon GE, Ziebell RA, Johnson E, Shortreed SM Do health records data accurately identify repeat self-harm after emergency department visits? 2025 Jun 27 doi: 10.1101/2025.06.26.25330358. Epub 2025-06-27. PubMed
Claire Allen, MPHManager, Collaborative Science |
Katharine A. Bradley, MD, MPHSenior Investigator |
Yates Coley, PhDAssociate Biostatistics Investigator |
Beverly B. Green, MD, MPHSenior Investigator |
Annie Hoopes, MD, MPHAssistant Investigator |
Paula Lozano, MD, MPHSenior Investigator; Director, ACT Center |
James D. Ralston, MD, MPHSenior Investigator |
Brian D. Williamson, PhDAssociate Biostatistics Investigator |