Vaccines & Infectious Diseases

“To improve the health of our communities we are comprehensively evaluating the safety and effectiveness of vaccines in current use, conducting clinical trials of promising new vaccines, and studying the patterns of infectious diseases in our population.”

Lisa A. Jackson, MD, MPH
Kaiser Permanente Washington Health Research Institute Senior Investigator

Research overview

Vaccines save lives by protecting people against infectious diseases—polio, influenza, and viral hepatitis to name a few. But recently, particularly in the Northwest, people have delayed or refused vaccination because of safety fears, leading to local outbreaks of potentially deadly diseases such as whooping cough and measles. Kaiser Permanente Washington is working to protect communities by continually improving the safety and effectiveness of vaccines.

Kaiser Permanente Washington research projects on vaccines and infectious diseases include:

  • clinical trials of promising vaccines and infectious disease treatments by the Vaccine and Treatment Evaluation Unit led by Kaiser Permanente Washington Health Research Institute (KPWHRI) Senior Investigator and Washington Permanente Medical Group physician Lisa A. Jackson, MD, MPH, and funded through 2021 by the National Institutes of Health;
  • ongoing monitoring of influenza vaccine effectiveness by the U.S. Influenza Vaccine Effectiveness Network, led by Michael L. Jackson, PhD, MPH, KPWHRI associate investigator, and funded by the Centers for Disease Control and Prevention (CDC); and
  • studies of immunization safety through the Vaccine Safety Datalink (VSD) Project, supported by the CDC and connecting information in large databases maintained by eight American health plans including Kaiser Permanente Washington.

Successes over three decades of KPWHRI research on vaccine safety and effectiveness include:

  • a large study of flu vaccination in seniors that found that the vaccine might not protect them from pneumonia as well as hoped;
  • a “real-time” evaluation of the safety of the new shingles vaccine in older adults across the VSD network;
  • clinical trials of investigational flu vaccines, including ones against pandemic flu and bird flu, in adults;
  • the biggest retrospective study of pneumococcal polysaccharide vaccine effectiveness in adults and the largest clinical trial on the safety of this vaccine; and
  • the pivotal clinical trials of 7-valent, 13-valent, and 20-valent pneumococcal conjugate vaccines in older adults.

Recent publications on Vaccines & Infectious Disease

Shang M, Chung JR, Jackson ML, Jackson LA, Monto AS, Martin ET, Belongia EA, McLean HQ, Gaglani M, Murthy K, Zimmerman RK, Nowalk MP, Fry AM, Flannery B. Influenza vaccine effectiveness among patients with high-risk medical conditions in the United States, 2012-2016. Vaccine. 2018 Nov 9. pii: S0264-410X(18)31490-7. doi: 10.1016/j.vaccine.2018.10.093. [Epub ahead of print]. PubMed

Appiah GD, Chung JR, Flannery B, Havers F, Zimmerman RK, Nowalk MP, Monto AS, Martin ET, Gaglani M, Murthy K, Jackson LA, Jackson ML, McLean HQ, Belongia EA, Fry AM. Hospitalization following outpatient medical care for influenza: US Influenza Vaccine Effectiveness Network, 2011-12-2015-16. Influenza Other Respir Viruses. 2018 Nov 8. doi: 10.1111/irv.12616. [Epub ahead of print]. PubMed

Munoz FM, Jackson LA, Swamy GK, Edwards KM, Frey SE, Stephens I, Ault K, Winokur P, Petrie CR, Wolff M, Patel SM, Keitel WA. Safety and immunogenicity of seasonal trivalent inactivated influenza vaccines in pregnant women. Vaccine. 2018 Nov 8. pii: S0264-410X(18)31475-0. doi: 10.1016/j.vaccine.2018.10.088. [Epub ahead of print]. PubMed

Frost MC, Matson TE, Tsui JI, Williams EC. Influence of comorbid drug use disorder on receipt of evidence-based treatment for alcohol use disorder among VA patients with alcohol use disorder and hepatitis C and/or HIV. Drug Alcohol Depend. 2019 Jan 1;194:288-295. doi: 10.1016/j.drugalcdep.2018.10.008. Epub 2018 Oct 30. PubMed

Havers FP, Chung JR, Belongia EA, McLean HQ, Gaglani M, Murthy K, Zimmerman RK, Nowalk MP, Jackson ML, Jackson LA, Monto AS, Petrie JG, Fry AM, Flannery B. Influenza vaccine effectiveness and statin use among adults in the United States, 2011-2017. Clin Infect Dis. 2018 Oct 27. pii: 5145968. doi: 10.1093/cid/ciy780. [Epub ahead of print]. PubMed

Researchers in Vaccines & Infectious Disease

Lisa A. Jackson, MD, MPH

Senior Investigator
206-442-5216
Lisa.A.Jackson@kp.org

Curriculum vitae (CV)

Jennifer C. Nelson, PhD

Director of Biostatistics; Senior Investigator
206-287-2004
Jen.Nelson@kp.org

Curriculum vitae (CV)

Michael L. Jackson, PhD, MPH

Associate Investigator
206-287-2220
Michael.L.Jackson@kp.org

Curriculum vitae (CV)

Andrea J. Cook, PhD

Senior Investigator
206-287-4257
Andrea.J.Cook@kp.org

Curriculum vitae (CV)

Sascha Dublin, MD, PhD

Senior Investigator
206-287-2870
Sascha.Dublin@kp.org

Curriculum vitae (CV)

Onchee Yu, MS

Senior Biostatistician
206-287-2389
Onchee.Yu@kp.org

Curriculum vitae (CV)

Robert D. Wellman, MS

Biostatistician
206-287-2557
Robert.D.Wellman@kp.org

Curriculum vitae (CV)

Affiliate researchers

Doug Opel, MD, MPH
University of Washington (UW) Department of Bioethics and Humanities; UW Department of Pediatrics; UW Medical Center

Adjunct researchers

John Dunn, MD, MPH
Kaiser Foundation Health Plan of Washington

Elizabeth Lin, MD, MPH
Kaiser Foundation Health Plan of Washington Family Practice;
Kaiser Permanente Washington Health Research Institute