Vaccines & Infectious Diseases

“To improve the health of our communities we are comprehensively evaluating the safety and effectiveness of vaccines in current use, conducting clinical trials of promising new vaccines, and studying the patterns of infectious diseases in our population.”

Lisa A. Jackson, MD, MPH
Kaiser Permanente Washington Health Research Institute Senior Investigator

Research overview

Vaccines save lives by protecting people against infectious diseases—polio, influenza, and viral hepatitis to name a few. But recently, particularly in the Northwest, people have delayed or refused vaccination because of safety fears, leading to local outbreaks of potentially deadly diseases such as whooping cough and measles. Kaiser Permanente Washington is working to protect communities by continually improving the safety and effectiveness of vaccines.

Kaiser Permanente Washington research projects on vaccines and infectious diseases include:

  • clinical trials of promising vaccines and infectious disease treatments by the Vaccine and Treatment Evaluation Unit led by Kaiser Permanente Washington Health Research Institute (KPWHRI) Senior Investigator and Washington Permanente Medical Group physician Lisa A. Jackson, MD, MPH, and funded through 2021 by the National Institutes of Health;
  • ongoing monitoring of influenza vaccine effectiveness by the U.S. Influenza Vaccine Effectiveness Network, led by Michael L. Jackson, PhD, MPH, KPWHRI associate investigator, and funded by the Centers for Disease Control and Prevention (CDC); and
  • studies of immunization safety through the Vaccine Safety Datalink (VSD) Project, supported by the CDC and connecting information in large databases maintained by eight American health plans including Kaiser Permanente Washington.

Successes over three decades of KPWHRI research on vaccine safety and effectiveness include:

  • a large study of flu vaccination in seniors that found that the vaccine might not protect them from pneumonia as well as hoped;
  • a “real-time” evaluation of the safety of the new shingles vaccine in older adults across the VSD network;
  • clinical trials of investigational flu vaccines, including ones against pandemic flu and bird flu, in adults;
  • the biggest retrospective study of pneumococcal polysaccharide vaccine effectiveness in adults and the largest clinical trial on the safety of this vaccine; and
  • the pivotal clinical trials of 7-valent, 13-valent, and 20-valent pneumococcal conjugate vaccines in older adults.

Recent publications on Vaccines & Infectious Disease

Thompson MG, Kwong JC, Regan AK, Katz MA, Drews SJ, Azziz-Baumgartner E, Klein NP, Chung H, Effler PV, Feldman BS, Simmonds K, Wyant BE, Dawood FS, Jackson ML, Fell DB, Levy A, Barda N, Svenson LW, Fink RV, Ball SW, Naleway A. Influenza vaccine effectiveness in preventing influenza-associated hospitalizations during pregnancy: a multi-country retrospective test negative design study, 2010-2016. Clin Infect Dis. 2018 Oct 11. pii: 5126390. doi: 10.1093/cid/ciy737. [Epub ahead of print]. PubMed

Flannery B, Chung JR, Monto AS, Martin ET, Belongia EA, McLean HQ, Gaglani M, Murthy K, Zimmerman RK, Nowalk MP, Jackson ML, Jackson LA, Rolfes MA, Spencer S, Fry AM. Influenza Vaccine Effectiveness in the United States during the 2016-2017 Season. LID - 10.1093/cid/ciy775 [doi] Clin Infect Dis. 2018 Sep 11. pii: 5094815. doi: 10.1093/cid/ciy775 [Epub ahead of print] PubMed

Groom HC, Irving SA, Koppolu P, Smith N, Vazquez-Benitez G, Kharbanda EO, Daley MF, Donahue JG, Getahun D, Jackson LA, Tse Kawai A, Klein NP, McCarthy NL, Nordin JD, Sukumaran L, Naleway AL. Uptake and safety of Hepatitis B vaccination during pregnancy: A Vaccine Safety Datalink study. LID - S0264-410X(18)31214-3 [pii] LID - 10.1016/j.vaccine.2018.08.074 [doi] Vaccine. 2018 Sep 4. pii: S0264-410X(18)31214-3. doi: 10.1016/j.vaccine.2018.08.074 [Epub ahead of print] PubMed

Henrikson NB, Zhu W, Baba L, Nguyen M, Berthoud H, Gundersen G, Hofstetter AM. Outreach and reminders to improve human papillomavirus vaccination in an integrated primary care system. Clin Pediatr (Phila). 2018 Jul 1:9922818787868. doi: 10.1177/0009922818787868. [Epub ahead of print]. PubMed

Brady RC, Jackson LA, Frey SE, Shane AL, Walter EB, Swamy GK, Schlaudecker EP, Szefer E, Wolff M, McNeal MM, Bernstein DI, Steinhoff MC. Randomized trial comparing the safety and antibody responses to live attenuated versus inactivated influenza vaccine when administered to breastfeeding women. Vaccine. 2018;36(31):4663-4671. doi: 10.1016/j.vaccine.2018.06.036. Epub 2018 Jun 28. PubMed

Researchers in Vaccines & Infectious Disease

Lisa A. Jackson, MD, MPH

Senior Investigator
206-442-5216
Lisa.A.Jackson@kp.org

Curriculum vitae (CV)

Jennifer C. Nelson, PhD

Director of Biostatistics; Senior Investigator
206-287-2004
Jen.Nelson@kp.org

Curriculum vitae (CV)

Michael L. Jackson, PhD, MPH

Associate Investigator
206-287-2220
Michael.L.Jackson@kp.org

Curriculum vitae (CV)

Andrea J. Cook, PhD

Senior Investigator
206-287-4257
Andrea.J.Cook@kp.org

Curriculum vitae (CV)

Sascha Dublin, MD, PhD

Senior Investigator
206-287-2870
Sascha.Dublin@kp.org

Curriculum vitae (CV)

Onchee Yu, MS

Senior Biostatistician
206-287-2389
Onchee.Yu@kp.org

Curriculum vitae (CV)

Robert D. Wellman, MS

Biostatistician
206-287-2557
Robert.D.Wellman@kp.org

Curriculum vitae (CV)

Affiliate researchers

Doug Opel, MD, MPH
University of Washington (UW) Department of Bioethics and Humanities; UW Department of Pediatrics; UW Medical Center

Adjunct researchers

John Dunn, MD, MPH
Kaiser Foundation Health Plan of Washington

Elizabeth Lin, MD, MPH
Kaiser Foundation Health Plan of Washington Family Practice;
Kaiser Permanente Washington Health Research Institute