Cancer is complex and can be a devastating diagnosis for individuals and their families. Our researchers work to improve cancer control on many levels, from prevention and screening through treatment and survivorship.
Kaiser Permanente Washington Health Research Institute (KPWHRI) has been studying how to provide life-saving breast cancer screening since 1986. In a novel initiative, researchers used a computer-based registry and collaborations with organizations across the U.S. before electronic health records existed and multi-site studies were common. The program ultimately led to a rich portfolio of studies not only on breast cancer, but also on colorectal, blood, cervical, lung, and thyroid cancers.
“Decades later, Kaiser Permanente Washington is just as committed to developing and evaluating innovations in cancer care,” said Karen Wernli, PhD, KPWHRI senior investigator.
The core of KPWHRI cancer research lies in its participation in many collaborative networks and programs. “Collaboration increases the power of Kaiser Permanente studies and helps us learn from different populations and health care settings,” said Senior Investigator Jessica Chubak, PhD. Examples of these networks include:
Breast Cancer Surveillance Consortium (BCSC)
The BCSC identifies strategies that detect aggressive breast cancer early, minimize harms, and reach diverse communities. Results help policymakers and health systems improve breast cancer screening and surveillance outcomes. The Kaiser Permanente Washington Breast Imaging Registry contributes to this national effort and the BCSC Statistical Coordinating Center resides at KPWHRI.
Population-based Research to Optimize the Screening Process (PROSPR)
The PROSPR national consortium conducts research to improve screening for cervical, colorectal, and lung cancers. PROSPR results will help optimize and tailor screening for different subgroups of the population.
Kaiser Permanente Research Bank (KPRB) Cancer Cohort
The KPRB Cancer Cohort is a national resource for understanding genetic, lifestyle, and environmental factors that contribute to cancer etiology and survival. Electronic health record data, stored tissue specimens, detailed treatment data, and the ability to follow patients for recurrence and mortality are accelerating progress toward improved cancer care.
Some of the cancer research group’s current studies include:
Past findings include:
Kantor ED, O’Connell KO, Ergas IJ, Valice E, Roh JM, Bhimani J, Heon N, Griggs JJ, Lee J, Bowles EJA, Rivera DR, Kolevska T, Bandera EV, Kushi LH. Assessment of breast cancer chemotherapy dose reduction in an integrated healthcare delivery system. Breast Cancer Res Treat. 2023 Nov 4. doi: 10.1007/s10549-023-07126-4. Online ahead of print. PubMed
Kerlikowske K, Zhu W, Su YR, Sprague BL, Stout NK, Onega T, O'Meara ES, Henderson LM, Tosteson ANA, Wernli K, Miglioretti DL. Supplemental magnetic resonance imaging plus mammography compared with magnetic resonance imaging or mammography by extent of breast density. J Natl Cancer Inst. 2023 Oct 27:djad201. doi: 10.1093/jnci/djad201. [Epub ahead of print]. PubMed
Thomas M, Su YR, Rosenthal EA, Sakoda LC, Schmit SL, Timofeeva MN, Chen Z, Fernandez-Rozadilla C, Law PJ, Murphy N, Carreras-Torres R, Diez-Obrero V, van Duijnhoven FJB, Jiang S, Shin A, Wolk A, Phipps AI, Burnett-Hartman A, Gsur A, Chan AT, Zauber AG, Wu AH, Lindblom A, Um CY, Tangen CM, Gignoux C, Newton C, Haiman CA, Qu C, Bishop DT, Buchanan DD, Crosslin DR, Conti DV, Kim DH, Hauser E, White E, Siegel E, Schumacher FR, Rennert G, Giles GG, Hampel H, Brenner H, Oze I, Oh JH, Lee JK, Schneider JL, Chang-Claude J, Kim J, Huyghe JR, Zheng J, Hampe J, Greenson J, Hopper JL, Palmer JR, Visvanathan K, Matsuo K, Matsuda K, Jung KJ, Li L, Le Marchand L, Vodickova L, Bujanda L, Gunter MJ, Matejcic M, Jenkins MA, Slattery ML, D'Amato M, Wang M, Hoffmeister M, Woods MO, Kim M, Song M, Iwasaki M, Du M, Udaltsova N, Sawada N, Vodicka P, Campbell PT, Newcomb PA, Cai Q, Pearlman R, Pai RK, Schoen RE, Steinfelder RS, Haile RW, Vandenputtelaar R, Prentice RL, Küry S, Castellví-Bel S, Tsugane S, Berndt SI, Lee SC, Brezina S, Weinstein SJ, Chanock SJ, Jee SH, Kweon SS, Vadaparampil S, Harrison TA, Yamaji T, Keku TO, Vymetalkova V, Arndt V, Jia WH, Shu XO, Lin Y, Ahn YO, Stadler ZK, Guelpen BV, Ulrich CM, Platz EA, Potter JD, Li CI, Meester RR, Moreno V, Figueiredo JC, Casey G, Vogelaar IL, Dunlop MG, Gruber SB, Hayes RB, Pharoah PD, Houlston RS, Jarvik GP, Tomlinson IP, Zheng W, Corley DA, Peters U, Hsu L. Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations. Nat Commun. 2023;14(1):6147. doi: 10.1038/s41467-023-41819-0. PubMed
Hahn EE, Staab J, Munoz-Plaza C, Gander J, Kushi L, McMullin C, Oshiro C, Wernli KJ, Ritzwoller D. Incidence and survival for breast, colorectal and lung cancer patients in an integrated system. Perm J. 2023 Sep 19;1-7. doi: 10.7812/TPP/23.021. Online ahead of print. PubMed
Onega T, Abraham L, Miglioretti DL, Lee CI, Henderson LM, Kerlikowske K, Tosteson ANA, Weaver D, Sprague BL, Bowles EJA, di Florio-Alexander RM. Digital mammography and digital breast tomosynthesis for detecting invasive lobular and ductal carcinoma. Breast Cancer Res Treat. 2023 Dec;202(3):505-514. doi: 10.1007/s10549-023-07051-6. Epub 2023 Sep 11. PubMed
Melissa L. Anderson, MSPrincipal Collaborative Biostatistician |
Erin J. Bowles, MPHDirector, Collaborative Science |
Jessica Chubak, PhDSenior Investigator |
Yates Coley, PhDAssociate Biostatistics Investigator |
Andrea J. Cook, PhDSenior Biostatistics Investigator |
Marlaine Figueroa Gray, PhDAssistant Investigator |
Beverly B. Green, MD, MPHSenior Investigator |
Laura E. Ichikawa, MSPrincipal Collaborative Biostatistician |
Jennifer B. McClure, PhDDirector, Investigative Science |
Ellen O'Meara, PhDPrincipal Collaborative Scientist |
Lorella Palazzo, PhDSenior Collaborative Scientist |
Gaia Pocobelli, PhDSenior Collaborative Scientist |
Rod L. Walker, MSPrincipal Collaborative Biostatistician |
Robert D. Wellman, MSPrincipal Collaborative Biostatistician |
Karen Wernli, PhDSenior Investigator |
Onchee Yu, MSPrincipal Collaborative Biostatistician |
Weiwei Zhu, MSSenior Collaborative Biostatistician |
Yu-Ru Su, PhDAssociate Biostatistics Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Noorie Hyun, PhDAssociate Biostatistics Investigator |
Pamela A. Shaw, PhD, MSSenior Biostatistics Investigator |
Nicole M. Gatto, PhD, MPHPrincipal Collaborative Scientist |
Meagan C. Brown, PhD, MPHAssistant Investigator |
Nora Henrikson, PhD, MPHAssociate Investigator |
Lily N. Shapiro, PhDCollaborative Scientist |
Wylie Burke, MD, PhD
University of Washington (UW) Department of Medical History and Ethics
Joann G. Elmore, MD, MPH
Harborview Medical Center; UW Department of Epidemiology
Larry Kessler, ScD
UW Department of Health Services
Constance D. Lehman, MD, PhD
Seattle Cancer Care Alliance; UW Department of Radiology
Kathy Leppig, MD
Kaiser Foundation Health Plan of Washington; UW Department of Pathology
Peggy L. Porter, MD
Fred Hutchinson Cancer Research Center (FHCRC); UW Department of Pathology
Emily White, PhD
FHCRC; UW Department of Epidemiology
Rachel Winer, PhD, MPH
Fred Hutchinson/UW Cancer Consortium; UW Department of Epidemiology