Onchee Yu, MS

“I'm pleased that my work is having a national impact by making vaccines, drugs, and medical devices even more effective and safe.”

Onchee Yu, MS

Senior Biostatistician, Kaiser Permanente Washington Health Research Institute

Biography

Onchee Yu, MS, is a biostatistician who has contributed her extensive experience in statistical applications to studies ranging from breast cancer screening and prevention to pharmacoepidemiology to vaccine safety and effectiveness. Ms. Yu has been a key member of KPWHRI's immunization research program for almost 15 years. Her work focuses on accurately measuring vaccine effectiveness, side effects, and safety. She has studied the influenza vaccine in general populations, the pneumococcal vaccine in older people, and the diphtheria-tetanus-pertussis (DTaP) vaccine in children. With KPWHRI collaborators Jennifer Nelson, PhD and Andrea Cook, PhD, Ms. Yu works on the Vaccine Safety Datalink and Mini-Sentinel projects that are developing and improving statistical methods for monitoring the safety of vaccines and drugs already on the market.

Much of Ms. Yu's recent research is in pharmacoepidemiology, which is studying how drugs are used in a population and their impact on public health. She is an expert in statistical analysis in a complex, clinically important area—determining if taking medicine for one condition affects risk of other illnesses. For example, Ms. Yu has coauthored studies on whether taking medications for heart disease or using antibiotics affects risk of breast cancer recurrence. She has evaluated how different classes of medication affect outcomes such as dementia.

Ms. Yu is a member of the American Statistical Association. Her methodological expertise includes classification and regression tree analysis and survival analysis.

Research interests and experience

  • Biostatistics

    Survival analysis; classification and regression tree analysis

  • Vaccines & Infectious Diseases

    Biostatistics; vaccine safety and efficacy; post-marketing vaccine safety study design and analysis

  • Medication Use & Patient Safety

    Biostatistics; medication use and cancer outcomes; medication use and dementia outcomes; post-marketing drug and vaccine safety study design and analysis; safety signal detection methods

Recent publications

Pocobelli G, Yu O, Fuller S, Fraser JR, Wartko P, Chen L, Newton K, Dimer J, McCulloch D, Warwick S, Dublin S. One-step approach to identifying gestational diabetes mellitus: association with perinatal outcomes. Obstet Gynecol. 2018 Aug 17. doi: 10.1097/AOG.0000000000002780. [Epub ahead of print]. PubMed

Gray SL, Anderson ML, Hanlon JT, Dublin S, Walker RL, Hubbard RA, Yu O, Montine TJ, Crane PK, Sonne JA, Keene CD, Larson EB. Exposure to strong anticholinergic medications and dementia-related neuropathology in a community-based autopsy cohort. J Alzheimers Dis. 2018 Jul 21. pii: JAD171174. doi: 10.3233/JAD-171174. [Epub ahead of print]. PubMed

Jackson ML, Yu O, Nelson JC, Nordin JD, Tartof SY, Klein NP, Donahue JG, Irving SA, Glanz JM, McNeil MM, Jackson LA. Safety of repeated doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine in adults and adolescents. Pharmacoepidemiol Drug Saf. 2018 Jun 3. doi: 10.1002/pds.4569. [Epub ahead of print]. PubMed

Gray SL, Walker RL, Dublin S, Yu O, Bowles EJA, Anderson ML, Crane PK, Larson EB. Proton pump inhibitor use and dementia risk: prospective population-based study. J Am Geriatr Soc. 2017 Nov 14. doi: 10.1111/jgs.15073. [Epub ahead of print]. PubMed

 

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