Vaccines & Infectious Diseases

“We’re improving the benefits of vaccination programs at every step—from identifying high-risk populations that benefit from vaccines, to clinical trials of experimental vaccines, to post-marketing studies of vaccine safety and effectiveness.”

Michael L. Jackson, PhD, MPH
Kaiser Permanente Washington Health Research Institute Associate Investigator

Research overview

Vaccines save lives by protecting people against infectious diseases such as polio, measles, and viral hepatitis. But recently, particularly in the Northwest, people have delayed or refused vaccination because of safety fears, leading to local outbreaks of potentially deadly diseases like whooping cough. Kaiser Permanente Washington is working to protect communities by continually improving the safety and effectiveness of vaccines.

Kaiser Permanente Washington research projects on vaccines and infectious diseases include:

  • clinical trials of promising vaccines and infectious disease treatments by the Vaccine and Treatment Evaluation Unit (VTEU) led by Kaiser Permanente Washington Health Research Institute (KPWHRI) Senior Investigator and Washington Permanente Medical Group physician Lisa A. Jackson, MD, MPH, and funded through 2023 by the National Institute of Allergy and Infectious Diseases;
  • ongoing monitoring of influenza vaccination by the U.S. Influenza Vaccine Effectiveness Network, led by Michael L. Jackson, PhD, MPH, KPWHRI Associate Investigator, and funded by the  Centers for Disease Control and Prevention (CDC); and
  • studies of immunization safety through the Vaccine Safety Datalink (VSD) Project, supported by the CDC and connecting information in large databases maintained by eight American health plans including Kaiser Permanente Washington.

Successes over three decades of KPWHRI research on vaccine safety and effectiveness include:

  • a large study of flu vaccination in seniors that found that the vaccine might not protect them from pneumonia as well as hoped;
  • finding that nasal spray vaccine did not prevent flu effectively in young children in recent seasons;
  • clinical trials of flu vaccines, including ones against pandemic flu and bird flu, in adults;
  • the biggest retrospective study of pneumococcal polysaccharide vaccine effectiveness in adults and the largest clinical trial on the safety of this vaccine;
  • the first clinical trial of the 7-valent pneumococcal conjugate vaccine in older adults; and
  • pneumococcal vaccine studies in which Kaiser Permanente Washington participants helped improve adult vaccination strategies nationwide.

“Kaiser Permanente Washington gives us nearly unlimited potential to address vaccine effectiveness and safety questions of national and international importance," says Lisa Jackson, MD, MPH, a KPWHRI senior investigator and Washington Permanente Medical Group physician. "We benefit from data for the Kaiser Permanente Washington population, the experience of our multidisciplinary immunization research group, and the encouraging atmosphere for research at Kaiser Permanente Washington.”

Recent publications on Vaccines & Infectious Disease

Flannery B, Chung JR, Monto AS, Martin ET, Belongia EA, McLean HQ, Gaglani M, Murthy K, Zimmerman RK, Nowalk MP, Jackson ML, Jackson LA, Rolfes MA, Spencer S, Fry AM; US Flu VE Investigators. Influenza vaccine effectiveness in the United States during the 2016-2017 season. Clin Infect Dis. 2018 Sep 11. doi: 10.1093/cid/ciy775. [Epub ahead of print]. PubMed

Groom HC, Irving SA, Koppolu P, Smith N, Vazquez-Benitez G, Kharbanda EO, Daley MF, Donahue JG, Getahun D, Jackson LA, Tse Kawai A, Klein NP, McCarthy NL, Nordin JD, Sukumaran L, Naleway AL. Uptake and safety of hepatitis B vaccination during pregnancy: a vaccine safety datalink study. Vaccine. 2018 Oct 1;36(41):6111-6116. doi: 10.1016/j.vaccine.2018.08.074. Epub 2018 Sep 5. PubMed

Henrikson NB, Zhu W, Baba L, Nguyen M, Berthoud H, Gundersen G, Hofstetter AM. Outreach and reminders to improve human papillomavirus vaccination in an integrated primary care system. Clin Pediatr (Phila). 2018 Jul 1:9922818787868. doi: 10.1177/0009922818787868. [Epub ahead of print]. PubMed

Brady RC, Jackson LA, Frey SE, Shane AL, Walter EB, Swamy GK, Schlaudecker EP, Szefer E, Wolff M, McNeal MM, Bernstein DI, Steinhoff MC. Randomized trial comparing the safety and antibody responses to live attenuated versus inactivated influenza vaccine when administered to breastfeeding women. Vaccine. 2018;36(31):4663-4671. doi: 10.1016/j.vaccine.2018.06.036. Epub 2018 Jun 28. PubMed

Jackson ML, Yu O, Nelson JC, Nordin JD, Tartof SY, Klein NP, Donahue JG, Irving SA, Glanz JM, McNeil MM, Jackson LA. Safety of repeated doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine in adults and adolescents. Pharmacoepidemiol Drug Saf. 2018 Jun 3. doi: 10.1002/pds.4569. [Epub ahead of print]. PubMed

Researchers in Vaccines & Infectious Disease

Lisa A. Jackson, MD, MPH

Senior Investigator
206-442-5216
Lisa.A.Jackson@kp.org

Curriculum vitae (CV)

Jennifer C. Nelson, PhD

Director of Biostatistics; Senior Investigator
206-287-2004
Jen.Nelson@kp.org

Curriculum vitae (CV)

Michael L. Jackson, PhD, MPH

Associate Investigator
206-287-2220
Michael.L.Jackson@kp.org

Curriculum vitae (CV)

Andrea J. Cook, PhD

Senior Investigator
206-287-4257
Andrea.J.Cook@kp.org

Curriculum vitae (CV)

Sascha Dublin, MD, PhD

Senior Investigator
206-287-2870
Sascha.Dublin@kp.org

Curriculum vitae (CV)

Onchee Yu, MS

Senior Biostatistician
206-287-2389
Onchee.Yu@kp.org

Curriculum vitae (CV)

Robert D. Wellman, MS

Biostatistician
206-287-2557
Robert.D.Wellman@kp.org

Curriculum vitae (CV)

Affiliate researchers

Doug Opel, MD, MPH
University of Washington (UW) Department of Bioethics and Humanities; UW Department of Pediatrics; UW Medical Center

Adjunct researchers

John Dunn, MD, MPH
Kaiser Foundation Health Plan of Washington

Elizabeth Lin, MD, MPH
Kaiser Foundation Health Plan of Washington Family Practice;
Kaiser Permanente Washington Health Research Institute