Onchee Yu, MS

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"At KPWHRI, I apply statistical methods to studies ranging from women’s health to pharmacoepidemiology to vaccine safety and effectiveness, in an effort to improve health care for patients.”

Onchee Yu, MS

Principal Collaborative Biostatistician, Kaiser Permanente Washington Health Research Institute

Onchee.Yu@kp.org
206-287-2389

Biography

Onchee Yu, MS, is a biostatistician who has contributed her extensive experience in statistical applications to electronic health records (EHR) data to studies related to women’s health, pharmacoepidemiology, and vaccine safety and effectiveness. Ms. Yu has been a key member of Kaiser Permanente Washington Health Research Institute’s (KPWHRI) immunization research program for 20 years. Her work focuses on applying statistical methods to evaluate vaccine effectiveness, side effects, and safety. In collaboration with KPWHRI biostatisticians Jennifer Nelson, PhD, and Andrea Cook, PhD, Ms. Yu developed and improved statistical methods for monitoring the safety of postmarketing vaccines in the Vaccine Safety Datalink project.

Much of Ms. Yu's recent research is in pharmacoepidemiology, which is studying how drugs are used in a population and their impact on public health. She is an expert in statistical analysis in a complex, clinically important area—determining if taking medicine for one condition (for example, cardiovascular medications) affects risk of other illnesses (for example, cancer outcomes).

Ms. Yu also contributes to women’s health. Using extensive EHR data and in collaboration with University of Washington clinician and KPWHRI affiliate researcher Susan D. Reed, MD, MPH, Ms. Yu has estimated incidences and prevalences, validated diagnosis codes, and developed automated case-finding algorithms for women’s health conditions including uterine fibroids, adenomyosis and endometriosis.  

Ms. Yu obtained her MS in biostatistics from the University of Washington in 1999. She is a member of the American Statistical Association and the International Society for Pharmacoepidemiology. Her statistical methodological expertise includes classification and regression tree analysis, and survival analysis.

Research interests and experience

  • Biostatistics

    Survival analysis; classification and regression tree analysis

  • Cancer

    Biostatistics; medication use and cancer outcomes

  • Vaccines & Infectious Diseases

    Biostatistics; vaccine safety and efficacy; postmarketing vaccine safety study design and analysis

    Women's Health

    Biostatistics; incidence and prevalence estimations; validation of diagnosis codes; automated case-finding algorithms

  • Medication Use & Patient Safety

    Biostatistics; medication use and cancer outcomes; postmarketing drug and vaccine safety study design and analysis; safety signal detection methods

Recent publications

Spangler L, Yu O, Loggers E, Boudreau DM. Bone mineral density screening among women with a history of breast cancer treated with aromatase inhibitors.  J Womens Health (Larchmt). 2013 Feb;22(2):132-40. doi: 10.1089/jwh.2012.3687. Epub 2013 Jan 30. PubMed

Nelson JC, Yu O, Dominguez C, Cook AJ, Peterson D, Greene SK, Yih K, Daley MF, Jacobsen SJ, Klein NP, Weintraub E, Jackson LA. Adapting group sequential methods to observational postlicensure vaccine safety surveillance: results of a pentavalent combination DTaP-IPV-Hib vaccine safety study. Am J Epidemiol. 2013 Jan 15;177(2):131-41. doi: 10.1093/aje/kws317. Epub 2013 Jan 4. PubMed

Aiello Bowles EJ, Boudreau DM, Chubak J, Yu O, Fujii M, Chestnut J, Buist DS. Patient reported discontinuation of endocrine therapy and related side effects among women with early stage breast cancer. J Oncol Prac. Nov 1 2012:e149-57. PubMed

Chubak J, Yu O, Pocobelli G, Lamerato L, Webster J, Prout MN, Ulcickas Yood M, Barlow WE, Buist DS. Administrative data algorithms to identify second breast cancer events following early-stage invasive┬ábreast cancer. J Natl Cancer Inst. 2012 Jun 20;104(12):931-40. Epub 2012 Apr 30. PubMed

Aiello Bowles EJ, Buist DS, Chubak J, Yu O, Johnson J, Chestnut J, Boudreau DM. Endocrine therapy initiation from 2001 through 2008 varies by age of breast cancer diagnosis and tumor size. J Oncol Pract. 2012;8(2):113-20. PubMed

 

Research

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Increasing opioid use disorder treatment in primary care

A trial led by KPWHRI researchers found that adding nurse care managers helped more people get needed treatment.

Research

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New numbers could help diagnose and treat a common, complex condition

Researchers gain better understanding of polycystic ovary syndrome's impact in U.S.

aging & geriatrics

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Do drugs cause falls for adults with dementia?

Researchers find a relationship between prescribed central nervous system-active medications and increased risk of falling among older people with dementia.