Onchee Yu, MS

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"At KPWHRI, I apply statistical methods to studies ranging from women’s health to pharmacoepidemiology to vaccine safety and effectiveness, in an effort to improve health care for patients.”

Onchee Yu, MS

Principal Collaborative Biostatistician, Kaiser Permanente Washington Health Research Institute

Onchee.Yu@kp.org
206-287-2389

Biography

Onchee Yu, MS, is a biostatistician who has extensive experience in statistical applications to electronic health records (EHR) data, which she has contributed to studies related to women’s health, pharmacoepidemiology, and vaccine safety and effectiveness. Ms. Yu has been a key member of the immunization research program at Kaiser Permanente Washington Health Research Institute (KPWHRI) over 20 years. Her work focuses on applying statistical methods to evaluate vaccine effectiveness, side effects, and safety. In collaboration with KPWHRI biostatisticians Jennifer Nelson, PhD, and Andrea Cook, PhD, Ms. Yu developed and improved statistical methods for monitoring the safety of postmarketing vaccines in the Vaccine Safety Datalink project.

Much of Ms. Yu's recent research is in pharmacoepidemiology, which is studying how drugs are used in a population and their impact on public health. She is an expert in statistical analysis in a complex, clinically important area — determining if medicine for one condition (for example, cardiovascular medications) affects risk of other illnesses (for example, dementia).

Addiction is another scientific area that Ms. Yu is involved in. In particular, she is a biostatistician on the PROUD (PRimary care Opioid Use Disorders) trial, a pragmatic implementation trial conducted in 6 diverse health systems to evaluate a program for increasing medication treatment for opioid use disorders within primary care settings.

Ms. Yu is also heavily involved in aging and geriatric research including collaborations with scientists on the Adult Changes in Thought (ACT) Study, a long-standing and ongoing longitudinal cohort study exploring risk factors related to dementia, Alzheimer's disease, and healthy aging. 

Ms. Yu obtained her master’s degree in biostatistics from the University of Washington in 1999. She also has prior experience and contribution to research in cancer and women’s health.

Research interests and experience

  • Biostatistics

    Survival analysis; classification and regression tree analysis

  • Cancer

    Biostatistics; medication use and cancer outcomes

  • Vaccines & Infectious Diseases

    Biostatistics; vaccine safety and efficacy; postmarketing vaccine safety study design and analysis

    Women's Health

    Biostatistics; incidence and prevalence estimations; validation of diagnosis codes; automated case-finding algorithms

  • Medication Use & Patient Safety

    Biostatistics; medication use and cancer outcomes; postmarketing drug and vaccine safety study design and analysis; safety signal detection methods

Recent publications

Elmore JG, Reisch LM, Barton MB, Barlow WE, Rolnick S, Harris EL, Herrinton LJ, Geiger AM, Beverly RK, Hart G, Yu O, Greene SM, Weiss NS, Fletcher SW. Efficacy of breast cancer screening in the community according to risk level.  J Natl Cancer Inst. 2005;97(14):1035-43. PubMed

Jumaan AO, Yu O, Jackson LA, Bohlke K, Galil K, Seward JF. Incidence of herpes zoster, before and after varicella-vaccination-associated decreases in the incidence of varicella, 1992-2002. J Infect Dis. 2005;191(12):2002-7. Epub 2005 May 12. PubMed

Jackson LA, Neuzil KM, Whitney CG, Starkovich P, Dunstan M, Yu O, Nelson JC, Feikin DR, Shay DK, Baggs J, Carste B, Nahm MH, Carlone G. Safety of varying dosages of 7-valent pneumococcal protein conjugate vaccine in seniors previously vaccinated with 23-valent pneumococcal polysaccharide vaccine. Vaccine. 2005;23(28):3697-703. PubMed

Herrinton LJ, Barlow WE, Yu O, Geiger AM, Elmore JG, Barton MB, Harris EL, Rolnick S, Pardee R, Husson G, Macedo A, Fletcher SW. Efficacy of prophylactic mastectomy in women with unilateral breast cancer. J Clin Oncol. 2005;23(19):4275-86. Epub 2005 Mar 28. PubMed

Geiger AM, Yu O, Herrinton LJ, Barlow WE, Harris EL, Rolnick S, Barton MB, Elmore JG, Fletcher SW. A population-based study of bilateral prophylactic mastectomy efficacy in women at elevated risk for breast cancer in community practices. Arch Intern Med. 2005;165(5):516-20. PubMed

 

Research

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Increasing opioid use disorder treatment in primary care

A trial led by KPWHRI researchers found that adding nurse care managers helped more people get needed treatment.

Research

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New numbers could help diagnose and treat a common, complex condition

Researchers gain better understanding of polycystic ovary syndrome's impact in U.S.

aging & geriatrics

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Do drugs cause falls for adults with dementia?

Researchers find a relationship between prescribed central nervous system-active medications and increased risk of falling among older people with dementia.