Onchee Yu, MS

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"At KPWHRI, I apply statistical methods to studies ranging from women’s health to pharmacoepidemiology to vaccine safety and effectiveness, in an effort to improve health care for patients.”

Onchee Yu, MS

Biostatistician III, Kaiser Permanente Washington Health Research Institute

Onchee.Yu@kp.org
206-287-2389

Biography

Onchee Yu, MS, is a biostatistician who has contributed her extensive experience in statistical applications to electronic health records (EHR) data to studies related to women’s health, pharmacoepidemiology, and vaccine safety and effectiveness. Ms. Yu has been a key member of Kaiser Permanente Washington Health Research Institute’s (KPWHRI) immunization research program for 20 years. Her work focuses on applying statistical methods to evaluate vaccine effectiveness, side effects, and safety. In collaboration with KPWHRI biostatisticians Jennifer Nelson, PhD, and Andrea Cook, PhD, Ms. Yu developed and improved statistical methods for monitoring the safety of postmarketing vaccines in the Vaccine Safety Datalink project.

Much of Ms. Yu's recent research is in pharmacoepidemiology, which is studying how drugs are used in a population and their impact on public health. She is an expert in statistical analysis in a complex, clinically important area—determining if taking medicine for one condition (for example, cardiovascular medications) affects risk of other illnesses (for example, cancer outcomes).

Ms. Yu also contributes to women’s health. Using extensive EHR data and in collaboration with University of Washington clinician and KPWHRI affiliate researcher Susan D. Reed, MD, MPH, Ms. Yu has estimated incidences and prevalences, validated diagnosis codes, and developed automated case-finding algorithms for women’s health conditions including uterine fibroids, adenomyosis and endometriosis.  

Ms. Yu obtained her MS in biostatistics from the University of Washington in 1999. She is a member of the American Statistical Association and the International Society for Pharmacoepidemiology. Her statistical methodological expertise includes classification and regression tree analysis, and survival analysis.

Research interests and experience

  • Biostatistics

    Survival analysis; classification and regression tree analysis

  • Cancer

    Biostatistics; medication use and cancer outcomes

  • Vaccines & Infectious Diseases

    Biostatistics; vaccine safety and efficacy; postmarketing vaccine safety study design and analysis

    Women's Health

    Biostatistics; incidence and prevalence estimations; validation of diagnosis codes; automated case-finding algorithms

  • Medication Use & Patient Safety

    Biostatistics; medication use and cancer outcomes; postmarketing drug and vaccine safety study design and analysis; safety signal detection methods

Recent publications

Dublin S, Walker RL, Gray SL, Hubbard RA, Anderson ML, Yu O, Crane PK, Larson EB. Prescription opioids and risk of dementia or cognitive decline: a prospective cohort study. J Am Geriatr Soc. 2015 Aug;63(8):1519-26. doi: 10.1111/jgs.13562.

Calip GS, Yu O, Hoskins KF, Boudreau DM. Associations between diabetes medication use and risk of second breast cancer events and mortality. Cancer Causes Control. 2015 May 9. [Epub ahead of print]. PubMed

Nelson JC, Cook AJ, Yu O, Zhao S, Jackson LA, Psaty BM. Methods for observational post-licensure medical product safety surveillance. Stat Methods Med Res. 2015 Apr;24(2):177-93. doi: 10.1177/0962280211413452. Epub 2011 Dec 2. PubMed

Gray SL, Anderson ML, Dublin S, Hanlon JT, Hubbard R, Walker R, Yu O, Crane PK, Larson EB. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med. 2015;175(3):401-7. doi:10.1001/jamainternmed.2014.7663. Epub 2015 Jan 26. PubMed

Boudreau DM, Yu O, Chubak J, Wirtz HS, Bowles EJ, Fujii M, Buist DS. Comparative safety of cardiovascular medication use and breast cancer outcomes among women with early stage breast cancer. Breast Cancer Res Treat. 2014 Apr;144(2):405-16. doi: 10.1007/s10549-014-2870-5. Epub 2014 Feb 21. PubMed

 

aging & geriatrics

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Do drugs cause falls for adults with dementia?

Researchers find a relationship between prescribed central nervous system-active medications and increased risk of falling among older people with dementia.

medication safety

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Using phentermine for weight loss longer term found to be safe, effective

Dr. David Arterburn discusses reassuring news from his PCORnet study of the most widely used anti-obesity drug in the United States.

research into action

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Can targeted flu vaccines lower the risk of hospitalization?

Dr. Paula Lozano explains how a Learning Health System project finds Kaiser Permanente Washington members who could benefit most from preventive services.