As the world’s population is aging, and U.S. baby boomers are entering their golden years, it’s only fitting that research at Kaiser Permanente Washington contributes to helping seniors to lead healthier lives.
“Research on aging cuts across virtually everything our institute does,” says Eric B. Larson, MD, MPH, a senior investigator who previously served as executive director of Kaiser Permanente Washington Health Research Institute (KPWHRI) and Kaiser Permanente Washington vice president for research and health care innovation. This includes studies of older women’s health, mental health issues in the elderly, and controlling cancers and chronic illnesses that become more common with age. The widely cited Chronic Care Model, developed at KPWHRI’s MacColl Center for Health Care Innovation, is now the leading care-design model for everyone, including older people, with chronic disease. Now, funding for aging research, especially Alzheimer’s and related disorders, offers even great opportunities for embedded scientists and their teams.
The institute has hosted several long-running cohort studies, including the Seattle Longitudinal Study, begun in the early 1950s, and the Adult Changes in Thought (ACT) study, a collaboration with the University of Washington. For more than 30 years, ACT researchers, led by Dr. Larson, have focused on finding ways to delay or prevent Alzheimer’s disease, other dementias, and cognitive decline. Through ACT and related studies, the institute has discovered clues to healthy aging that translate into guidance for safely staying active, avoiding injurious falls, and reducing cardiovascular risks. These and other changes have likely contributed to lowering of dementia rates in some first-world countries. More recently, ACT researchers have also been contributing to research on traumatic brain injury and on the genetic foundations of various diseases, including Alzheimer’s.
In addition, the institute’s drug safety research contributes to better understanding of how certain common medications affect seniors’ well-being, including avoiding unsafe medications. Meanwhile, our investigators are also seeking ways to help seniors stay physically active, avoid unnecessary hospitalizations, and receive late-life care that best reflects their values and preferences.
“We’re learning what our study participants value as they grow older,” Dr. Larson says. “And we hope to apply that to help them have a positive experience with aging—promoting their independence and providing them with skills to cope with any problems that may occur.”
Park S, Jung J, Burke RE, Larson EB. Trends in use of low-value care in traditional fee-for-service Medicare and Medicare Advantage. JAMA Netw Open. 2021;4(3):e211762. doi: 10.1001/jamanetworkopen.2021.1762. PubMed
McCurry SM, Zhu W, Von Korff M, Wellman R, Morin CM, Thakral M, Yeung K, Vitiello MV. Effect of telephone cognitive behavioral therapy for insomnia in older adults with osteoarthritis pain: a randomized clinical trial. JAMA Intern Med. 2021 Feb 22:e209049. doi: 10.1001/jamainternmed.2020.9049. [Epub ahead of print]. PubMed
Ramirez M, Duran MC, Pabiniak CJ, Hansen KE, Kelley A, Ralston JD, McCurry SM, Teri L, Penfold RB. Family caregiver needs and preferences for virtual training to manage behavioral and psychological symptoms of dementia: interview study. JMIR Aging. 2021;4(1):e24965. doi: 10.2196/24965. PubMed
Zhou J, Walker RL, Gray SL, Marcum ZA, Barthold D, Bowen JD, McCormick W, McCurry SM, Larson EB, Crane PK. Glucose-dementia association is consistent over blood pressure/antihypertensive groups. J Alzheimers Dis. 2021 Jan 30. doi: 10.3233/JAD-201138. [Epub ahead of print]. PubMed
den Brok MGHE, van Dalen JW, Abdulrahman H, Larson EB, van Middelaar T, van Gool WA, van Charante EPM, Richard E. Antihypertensive medication classes and the risk of dementia: a systematic review and network meta-analysis. J Am Med Dir Assoc. 2021 Jan 16:S1525-8610(20)31068-9. doi: 10.1016/j.jamda.2020.12.019 [Epub ahead of print] PubMed
![]() Eric B. Larson, MD, MPH, MACPSenior Investigator and former Executive Director, Kaiser Permanente Washington Health Research Institute; Former Vice President for Research and Health Care Innovation, Kaiser Permanente Washington |
![]() Sascha Dublin, MD, PhDSenior Investigator |
![]() Diana S. Buist, PhD, MPHDirector of Research and Strategic Partnerships; Senior Investigator |
![]() Dori E. Rosenberg, PhD, MPHAssociate Investigator |
![]() Erin J. Bowles, MPHResearch Associate |
![]() Ellen O'Meara, PhDSenior Research Associate |
![]() Melissa L. Anderson, MSBiostatistician III |
![]() Rod L. Walker, MSBiostatistician III |
![]() Laura Harrington, PhD, MPHAssistant Investigator |
![]() Michael L. Parchman, MD, MPHSenior Investigator, MacColl Center for Health Care Innovation |
![]() Katie Coleman, MSPHDirector, MacColl Center for Health Care Innovation; Director, Learning Health System Program |
![]() Denise M. Boudreau, PhDSenior Investigator |
![]() Robert Penfold, PhDSenior Investigator |
![]() Marlaine Gray, PhDAssistant Investigator |
![]() Ben Balderson, PhDResearch Associate |
![]() Jing Zhou, PhDBiostatistician II |
![]() Jennifer C. Nelson, PhDDirector of Biostatistics; Senior Investigator |
![]() Onchee Yu, MSBiostatistician III |
![]() Jessica Chubak, PhD, MBHLSenior Investigator |
![]() Nora Henrikson, PhD, MPHAssistant Investigator |
![]() Yu-Ru Su, PhDAssistant Investigator |
![]() Julia J. Smith, MSBiostatistician III |
Paul Crane, MD, MPH
Professor, Internal Medicine
University of Washington
Sue McCurry, PhD
Research Professor, Psychosocial and Community Health
University of Washington
Linda Teri, PhD
Professor, Psychosocial & Community Health
Director, Northwest Research Group on Aging, Psychosocial and Community Health
University of Washington
Shelly Gray, PharmD, MS, AGSF
Professor, Department of Pharmacy
University of Washington
Zachary A. Marcum, PhD, PharmD
Assistant Professor, School of Pharmacy
University of Washington
David R. Crosslin, PhD
Assistant Professor
Biomedical Informatics and Medical Education
Adjunct Faculty
Genome Sciences, Division of Medical Genetics
University of Washington
Janelle S. Taylor, PhD
Professor, Department of Anthropology
University of Toronto
Elizabeth Phelan, MD, MS
Associate Professor, Medicine/Gerontology and Geriatric Medicine
Harborview Medical Center
Adjunct Associate Professor, Health Services
University of Washington
Gail Jarvik, MD, PhD
Professor, Medical Genetics, Genome Sciences, Department of Medicine
University of Washington
James Floyd, MD, MS
Assistant Professor, Department of Medicine