Aging & Geriatrics

“Our ‘living laboratory’ produces practical findings that are helping seniors delay dementia and other debilitating conditions.”

Eric B. Larson, MD, MPH
Vice President for Research, Kaiser Permanente Washington
Executive Director, Kaiser Permanente Washington Health Research Institute

Research overview

The world’s population is aging, and many U.S. baby boomers are entering their golden years. So it’s only fitting that much research at Kaiser Permanente Washington contributes to helping seniors to lead healthier lives.

“Research on aging cuts across virtually everything our Institute does,” said Eric B. Larson, MD, MPH, the senior investigator who serves as executive director of Kaiser Permanente Washington Health Research Institute (KPWHRI) and Kaiser Permanente Washington vice president for research. This includes studies of older women’s health, mental health issues in the elderly, and controlling cancers and chronic illnesses that become more common with age. The widely cited Chronic Care Model, developed at KPWHRI’s MacColl Center for Health Care Innovation, is now the leading care-design model for everyone, including older people, with chronic disease.

The Institute also hosts several long-running cohort studies, including the Seattle Longitudinal Study, begun in the early 1950s, and the Adult Changes in Thought (ACT) study, a collaboration with the University of Washington. For more than 20 years, ACT researchers, led by Dr. Larson, have focused on finding ways to delay or prevent Alzheimer’s disease, other dementias, and cognitive decline. Through ACT and related studies, the Institute has discovered clues to healthy aging that translate into guidance for safely staying active and avoiding cardiovascular risks. More recently, ACT researchers have also been contributing to research on traumatic brain injury and on the genetic foundations of various diseases, including Alzheimer’s.

In addition, the Institute’s drug safety research contributes to better understanding of how certain common medications affect seniors’ well-being. Meanwhile, our investigators are also seeking ways to help seniors stay physically active, avoid unnecessary hospitalizations, and receive late-life care that best reflects their values and preferences.

“We’re learning what our study participants value as they grow older,” Larson said. “And we hope to apply that to help them have a positive experience with aging—promoting their independence and providing them with skills to cope with any problems that may occur.”

Recent publications on Aging & Geriatrics

Lee CS, Larson EB, Gibbons LE, Lee AY, McCurry SM, Bowen JD, McCormick WC, Crane PK. Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease. Alzheimers Dement. 2018 Aug 2. pii: S1552-5260(18)33034-6. doi: 10.1016/j.jalz.2018.06.2856. [Epub ahead of print]. PubMed

Gray SL, Anderson ML, Hanlon JT, Dublin S, Walker RL, Hubbard RA, Yu O, Montine TJ, Crane PK, Sonne JA, Keene CD, Larson EB. Exposure to strong anticholinergic medications and dementia-related neuropathology in a community-based autopsy cohort. J Alzheimers Dis. 2018 Jul 21. pii: JAD171174. doi: 10.3233/JAD-171174. [Epub ahead of print]. PubMed

Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018 Jul 2. pii: 10.1007/s00401-018-1881-4. doi: 10.1007/s00401-018-1881-4. [Epub ahead of print]. PubMed

Anttila V, Bulik-Sullivan B, Finucane HK, Walters R, Bras J, Duncan L, Escott-Price V, Falcome G, Gormley P, Malik R, Patsopoulos N, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze J-F, Duron E, Vardarajan BN, Reitz C, Goate Am, Huentelman MJ, Kamhoh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hadonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CE, Jicha GA, Kauwe JSK, Kaye, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ , Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore p, Morgan K, Rossor M, Lupton M, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee S, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt G, Freilinger T, Ran C, Gordon S, Borck G, Adams H, Lehtimäki T, Wedenoja J, Buring J, Schürks M, Hrafnsdottir M, Hottenga J-J, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin N, Montgomery G, Kurki M, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Ferrari M, Belin A, Maagdenberg A, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman D, Nyholt D, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino CB, Cossette P, Jonghe P, Depondt C, Dlugos D, Ferraro T, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz W, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller R, Molloy A, Ng P-W, Oliver K, Privitera M, Radtke R, Ruppert A-K, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya S, Smith P, Sperling M, Striano P, Surges R, Thomas NG, Visscher F, Whelan CD, Zara F, Heinzen E, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris H, Sharma M, Ryten M, Mok B, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Perica VB, Thornton LM, Huckins LM, Rayner NW, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder S, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julia A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold A, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasé M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Vasquez AA, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum A, Waldman I, Wilmot B, Molly N, Bau C, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet E, Medland SE, Robinson E, Weiss L, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green a, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, Moreno-De-Luca D, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Richard Delorme, Rogé B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra JG, Mayoral F, Schofield PR, Cichon S, Mühleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer T, Forstner AJ, Streit F, Baune BT, Tracy Air T, Sinnamon G, Wray N, MacIntyre D, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp C, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li Q, Nauck M, Schoevers RA, Beekman ATF, Knowles JA, Viktorin A, Arnold P, Barr C, Bedoya-Berrio G, Bienvenu O, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi DDarrow S, Denys D, Derks E, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hartmann A, Hirschtritt M, Hoekstra P, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon G, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel E, Pablo Mir P, Nicolini H, Okun MS, Pakstis A, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter M, Riddle M, Robertson M, Roessner V, Rosário M, Sandor P, Stein D, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland J, Wolanczyk T, Worbe Y, Goes F, McLaughlin N, Nestadt PS, Grabe H-J, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong S, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kucinskas V, Keong JLC, Limborska S, Loughland C, Nnqvist JL, Maher B, Mattheisen M, McDonald C, Murphy K, Nenadic I, Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders A, Schall U, Schwab S, Sim K, So H-C, Stögmann E, Subramaniam M, Toncheva D, Waddington J, James Walters J, Cheng W, Cloninger R, Curtis D, Frans Henskens F, Mattingsdal M, Oh S-Y, Scott R, Webb B, Churchhouse C, Breen G, Bulik C, Mark Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kenneth Kendler, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood N, Cotsapas C, Palotie A, Smoller J, Sullivan P, Rosand J, Corvin A, Neale BM, on behalf of the Brainstorm consortium. The analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757. PubMed

Matson TE, Renz AD, Takemoto ML, McClure JB, Rosenberg DE. Acceptability of a sitting reduction intervention for older adults with obesity. BMC Public Health. 2018;18(1):706. doi: 10.1186/s12889-018-5616-1. PubMed

Researchers in Aging & Geriatrics

Eric B. Larson, MD, MPH, MACP

Vice President for Research and Health Care Innovation, Kaiser Foundation Health Plan of Washington; Executive Director & Senior Investigator, KPWHRI
206-287-2988
Eric.B.Larson@kp.org

Curriculum vitae (CV)

Sascha Dublin, MD, PhD

Senior Investigator
206-287-2870
Sascha.Dublin@kp.org

Curriculum vitae (CV)

Diana S. Buist, PhD, MPH

Director of Research and Strategic Partnerships; Senior Investigator
206-287-2931
Diana.S.Buist@kp.org

Curriculum vitae (CV)

Andrea Z. LaCroix, PhD

Senior Investigator, KPWHRI; Professor and Chief of Epidemiology, Department of Family Medicine and Public Health, University of California, San Diego
858-822-1073
Alacroix@ucsd.edu

Curriculum vitae (CV)

Edward H. Wagner, MD, MPH

Director (Emeritus, Retired), MacColl Center for Health Care Innovation
206-287-2877
Brian.T.Austin@kp.org

Curriculum vitae (CV)

Dori E. Rosenberg, PhD, MPH

Associate Investigator
206-287-2532
Dori.E.Rosenberg@kp.org

Curriculum vitae (CV)

Erin J. Bowles, MPH

Research Associate
206-287-2708
Erin.A.Bowles@kp.org

Curriculum vitae (CV)

Ellen O'Meara, PhD

Research Associate
206-287-2938
Ellen.S.O'Meara@kp.org

Curriculum vitae (CV)

Melissa L. Anderson, MS

Senior Biostatistician
206-287-2647
Melissa.L.Anderson@kp.org

Curriculum vitae (CV)

Rod L. Walker, MS

Biostatistician
206-287-2895
Rod.L.Walker@kp.org

Curriculum vitae (CV)

Bridget Burke, PhD, MPH, MIS

Research Fellow
206-287-5252
Bridget.T.Burke@kp.org

Curriculum vitae (CV)

Laura Harrington, PhD, MPH

Assistant Investigator
206-287-2066
Laura.B.Harrington@kp.org

Curriculum vitae (CV)