Americans are using more prescription drugs than ever. Consequently, they’re coping with more side effects, drug interactions, and costs, especially if they’re using multiple medications. Kaiser Permanente Washington Health Research Institute (KPWHRI) scientists are on the forefront of answering questions about these concerns. We’re studying the beneficial and harmful effects of medications in real-world settings, and innovating better ways to manage and monitor drug use.
The institute contributes to national initiatives to monitor medication safety as well as providing information to help doctors and patients weigh the risks and benefits of various prescription drugs.
Funders of KPWHRI medication use and patient safety research include the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the National Institutes of Health, the Patient-Centered Outcomes Research Institute, and other sources. A few projects include:
Brown JS, Kulldorff M, Chan KA, Davis RL, Graham D, Pettus PT, Andrade SE, Raebel MA, Herrinton L, Roblin D, Boudreau D, Smith D, Gurwitz JH, Gunter MJ, Platt R. Early detection of adverse drug events within population-based health networks: application of sequential testing methods. Pharmacoepidemiol Drug Saf. 2007;16(12):1275-84. Epub 2007 Oct 22. PubMed
Brown JS, Kulldorff M, Petronis KR, Reynolds R, Chan KA, Davis RL, Graham D, Andrade SE, Raebel MA, Herrinton L, Roblin D, Boudreau D, Smith D, Gurwitz JH, Gunter MJ, Platt R. Early adverse drug event signal detection within population-based health networks using sequential methods: key methodologic considerations. Pharmacoepidemiol Drug Saf. 2009;18(3):226-34. PubMed
Brown JS, Petronis KR, Bate A, Zhang F, Inna Dashevsky I, Kulldorff M, Avery TR, Davis RL, Chan KA, Andrade SE, Boudreau D, Gunter MJ, Herrinton L, Pawloski P, Raebel MA, Roblin D, Smith D, Reynolds R. Drug adverse event detection in health plan data using the gamma poisson shrinker and comparison to the tree-based scan statistic. Pharmaceutics. 2013 Mar 14;5(1):179-200. doi: 10.3390/pharmaceutics5010179. PubMed
Brunner RL, Gass M, Aragaki A, Hays J, Granek I, Woods N, Mason E, Brzyski R, Ockene J, Assaf A, LaCroix A, Matthews K, Wallace R. Effects of conjugated equine estrogen on health-related quality of life in postmenopausal women with hysterectomy: results from the Women's Health Initiative Randomized Clinical Trial. Arch Intern Med. 2005;165(17):1976-86. PubMed
Buist DSM, LaCroix AZ, Newton KM. Long-term Hormone Replacement Therapy (HRT) users: are they different and why do they persist? Am J Epidemiol. 1997;145:S1.
Sascha Dublin, MD, PhDSenior Investigator |
Jessica Chubak, PhDSenior Investigator |
Andrea J. Cook, PhDSenior Biostatistics Investigator |
Rita Mangione-Smith, MD, MPHExecutive Director and Senior Investigator, KPWHRI; Vice President for Research and Health Care Innovation, Kaiser Permanente Washington |
Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
David E. Arterburn, MD, MPHSenior Investigator |
Susan M. Shortreed, PhDSenior Biostatistics Investigator |
Lisa A. Jackson, MD, MPHSenior Investigator |
Karen Wernli, PhDSenior Investigator |
Onchee Yu, MSPrincipal Collaborative Biostatistician |
Rod L. Walker, MSPrincipal Collaborative Biostatistician |
Robert D. Wellman, MSPrincipal Collaborative Biostatistician |
Gaia Pocobelli, PhDSenior Collaborative Scientist |
Laura Harrington, PhD, MPHAssistant Investigator |
Jennifer F. Bobb, PhDAssociate Biostatistics Investigator |
Weiwei Zhu, MSSenior Collaborative Biostatistician |
Paige D. Wartko, PhD, MPHSenior Collaborative Scientist |
Maricela Cruz, PhDAssistant Biostatistics Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Noorie Hyun, PhDAssociate Biostatistics Investigator |
Laurel Hansell, MA, MPHCollaborative Scientist |
Jess Mogk, MPHCollaborative Scientist |
Annie Piccorelli, PhDSenior Collaborative Biostatistician |
Susan Heckbert, MD, PhD
University of Washington (UW) Department of Epidemiology; UW Cardiovascular Health Research Unit
David Siscovick, MD, MPH
UW Department of Medicine; UW Department of Epidemiology; UW Cardiovascular Health Research Unit
Leslie Spangler, PhD
Amgen