Americans are using more prescription drugs than ever. Consequently, they’re coping with more side effects, drug interactions, and costs, especially if they’re using multiple medications. Kaiser Permanente Washington Health Research Institute (KPWHRI) scientists are on the forefront of answering questions about these concerns. We’re studying the beneficial and harmful effects of medications in real-world settings, and innovating better ways to manage and monitor drug use.
The institute contributes to national initiatives to monitor medication safety as well as providing information to help doctors and patients weigh the risks and benefits of various prescription drugs.
Funders of KPWHRI medication use and patient safety research include the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the National Institutes of Health, the Patient-Centered Outcomes Research Institute, and other sources. A few projects include:
Anthony MS, Reed SD, Armstrong MA, Getahun D, Gatz JL, Saltus CW, Zhou X, Schoendorf J, Postlethwaite DA, Raine-Bennett T, Fassett MJ, Peipert JF, Ritchey ME, Ichikawa LE, Lynen R, Alabaster AL, Merchant M, Chiu VY, Shi JM, Xie F, Hui SL, Wang J, Hunter S, Bartsch J, Frenz AK, Chillemi G, Im TM, Takhar HS, Asiimwe A. Design of the association of uterine perforation and expulsion of IUD (APEX-IUD) study: a multisite retrospective cohort study. Am J Obstet Gynecol. 2021 Jun;224(6):599.e1-599.e18. doi: 10.1016/j.ajog.2021.01.003. Epub 2021 Jan 15. PubMed
Stephens KA, Ike B, Baldwin LM, Packer C, Parchman M. Challenges and approaches to population management of long-term opioid therapy patients. J Am Board Fam Med. 2021 Jan-Feb;34(1):89-98. doi: 10.3122/jabfm.2021.01.190100. PubMed
Penfold RB, Thompson EE, Hilt RJ, Kelleher KJ, Schwartz N, Beck A, Clarke G, Ralston JD, Hartzler AL, Coley RY, Akosile M, Vitiello B, Simon GE. Safer Use of Antipsychotics in Youth (SUAY) pragmatic trial protocol. Contemp Clin Trials. 2020 Dec;99:106184. doi: 10.1016/j.cct.2020.106184. Epub 2020 Oct 20. PubMed
Kronman MP, Gerber JS, Grundmeier RW, Zhou C, Robinson JD, Heritage J, Stout J, Burges D, Hedrick B, Warren L, Shalowitz M, Shone LP, Steffes J, Wright M, Fiks AG, Mangione-Smith R. Reducing antibiotic prescribing in primary care for respiratory illness. Pediatrics. 2020 Aug 3:e20200038. doi: 10.1542/peds.2020-0038. [Epub ahead of print]. PubMed
Grossman DC, Larson EB, Sox HC. Integrating personalized medicine with population health management: the path forward. JAMA. 2020 Jul 30. doi: 10.1001/jama.2020.1406. [Epub ahead of print]. PubMed
![]() Sascha Dublin, MD, PhDSenior Investigator |
![]() Jessica Chubak, PhDSenior Investigator |
![]() Andrea J. Cook, PhDSenior Biostatistics Investigator |
![]() Rita Mangione-Smith, MD, MPHExecutive Director and Senior Investigator, KPWHRI; Vice President for Research and Health Care Innovation, Kaiser Permanente Washington |
![]() Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
![]() David E. Arterburn, MD, MPHSenior Investigator |
![]() Susan M. Shortreed, PhDSenior Biostatistics Investigator |
![]() Lisa A. Jackson, MD, MPHSenior Investigator |
![]() Karen Wernli, PhDSenior Investigator |
![]() Onchee Yu, MSPrincipal Collaborative Biostatistician |
![]() Rod L. Walker, MSSenior Collaborative Biostatistician |
![]() Robert D. Wellman, MSSenior Collaborative Biostatistician |
![]() Gaia Pocobelli, PhDSenior Collaborative Scientist |
![]() David S. Carrell, PhDAssociate Investigator |
![]() Laura Harrington, PhD, MPHAssistant Investigator |
![]() Jennifer F. Bobb, PhDAssociate Biostatistics Investigator |
![]() Weiwei Zhu, MSSenior Collaborative Biostatistician |
![]() Paige D. Wartko, PhD, MPHCollaborative Scientist |
![]() Maricela Cruz, PhDAssistant Biostatistics Investigator |
![]() Brian D. Williamson, PhDAssistant Biostatistics Investigator |
![]() Noorie Hyun, PhDAssistant Biostatistics Investigator |
![]() Laurel Hansell, MA, MPHCollaborative Scientist |
![]() Jess Mogk, MPHCollaborative Scientist |
Susan Heckbert, MD, PhD
University of Washington (UW) Department of Epidemiology; UW Cardiovascular Health Research Unit
David Siscovick, MD, MPH
UW Department of Medicine; UW Department of Epidemiology; UW Cardiovascular Health Research Unit
Leslie Spangler, PhD
Amgen