Americans are using more prescription drugs than ever. Consequently, they’re coping with more side effects, drug interactions, and costs, especially if they’re using multiple medications. Kaiser Permanente Washington Health Research Institute (KPWHRI) scientists are on the forefront of answering questions about these concerns. We’re studying the beneficial and harmful effects of medications in real-world settings, and innovating better ways to manage and monitor drug use.
The institute contributes to national initiatives to monitor medication safety as well as providing information to help doctors and patients weigh the risks and benefits of various prescription drugs.
Funders of KPWHRI medication use and patient safety research include the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, the National Institutes of Health, the Patient-Centered Outcomes Research Institute, and other sources. A few projects include:
McElwee NE, Schumacher MC, Johnson SC, Weir TW, Greene SL, Scotvold MJ, Hunter JR, Dinan BJ, Jick H. An observational study of isotretinoin recipients treated for acne in a health maintenance organization. Arch Dermatol. 1991;127(3):341-6. PubMed
Ellsworth AJ, Meyer EF, Larson EB. Acetazolamide or dexamethasone use versus placebo to prevent acute mountain sickness on Mount Rainier. West J Med. 1991;154(3):289-93. PubMed
Derby LE, Jick H. Renal parenchymal disease related to over-the-counter analgesic use. Pharmacotherapy. 1991;11(6):467-71. PubMed
Atkins D, Longstreth W, Larson EB, Psaty BM. Estrogen replacement, cholesterol and relative risk of stroke: A review. Clin Res. 1991;39:571A.
Schumacher MC, Jick SS, Jick H, Feld AD. Cimetidine use and gastric cancer. Epidemiology. 1990;1(3):251-4. PubMed
![]() Sascha Dublin, MD, PhDSenior Investigator |
![]() Jessica Chubak, PhDSenior Investigator |
![]() Andrea J. Cook, PhDSenior Biostatistics Investigator |
![]() Rita Mangione-Smith, MD, MPHExecutive Director and Senior Investigator, KPWHRI; Vice President for Research and Health Care Innovation, Kaiser Permanente Washington |
![]() Eric B. Larson, MD, MPH, MACPSenior Investigator and former Executive Director, KPWHRI; Former Vice President for Research and Health Care Innovation, KPWA |
![]() Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
![]() David E. Arterburn, MD, MPHSenior Investigator |
![]() Susan M. Shortreed, PhDSenior Biostatistics Investigator |
![]() Lisa A. Jackson, MD, MPHSenior Investigator |
![]() Karen Wernli, PhDAssociate Investigator |
![]() Onchee Yu, MSSenior Collaborative Biostatistician |
![]() Rod L. Walker, MSSenior Collaborative Biostatistician |
![]() Robert D. Wellman, MSSenior Collaborative Biostatistician |
![]() Gaia Pocobelli, PhDCollaborative Scientist |
![]() David S. Carrell, PhDAssociate Investigator |
![]() Laura Harrington, PhD, MPHAssistant Investigator |
![]() Jennifer F. Bobb, PhDAssociate Biostatistics Investigator |
![]() Weiwei Zhu, MSSenior Collaborative Biostatistician |
![]() Paige D. Wartko, PhD, MPHCollaborative Scientist |
![]() Maricela Cruz, PhDAssistant Biostatistics Investigator |
![]() Brian D. Williamson, PhDAssistant Biostatistics Investigator |
![]() Noorie Hyun, PhDAssistant Biostatistics Investigator |
![]() Laurel Hansell, MA, MPHCollaborative Scientist |
![]() Jess Mogk, MPHCollaborative Scientist |
Susan Heckbert, MD, PhD
University of Washington (UW) Department of Epidemiology; UW Cardiovascular Health Research Unit
David Siscovick, MD, MPH
UW Department of Medicine; UW Department of Epidemiology; UW Cardiovascular Health Research Unit
Leslie Spangler, PhD
Amgen