Diana L. Miglioretti, PhD

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“My research is about the risks and benefits of procedures such as cancer screening. I'm working to standardize medical imaging so patients can be confident they're getting the lowest radiation doses necessary for effective imaging.”

Diana L. Miglioretti, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute
Dean’s Professor of Biostatistics, University of California, Davis

(530) 752-7168

Twitter: @dmiglio

Biography

Senior investigator and professor of biostatistics Diana Miglioretti, PhD, is committed to improving health care by building the evidence base for personalized cancer screening. To achieve this goal, Dr. Miglioretti pursues a rigorous combination of applied and methodological research. Her work focuses on the benefits and risks of cancer screening and appropriate use of screening and diagnostic tools including medical imaging.

Dr. Miglioretti co-leads the Breast Cancer Surveillance Consortium (BCSC)—a network of breast imaging registries that has the largest and most comprehensive collection of breast cancer screening data in the nation. Established in 1994, the BCSC is currently supported by a $17 million program project grant from the National Cancer Institute. The vast BCSC database includes information on about 12 million film, digital, and 3D mammograms for more than 2.4 million women. The BCSC also has extensive data on newer methods such as digital breast tomosynthesis (also called 3D mammography) and breast MRI (magnetic resonance imaging).

Dr. Miglioretti’s expertise in maximizing the value of the BCSC data includes establishing and evaluating data collection, helping individual sites and outside researchers with analyses, and developing new statistical techniques. In part through her efforts, results from BCSC studies have helped guide national breast cancer screening policy decisions and clinical guidelines. A few examples of Dr. Miglioretti’s BCSC studies are:

Other examples of Dr. Miglioretti’s research include:

In addition to her KPWHRI faculty position, Dr. Miglioretti is the Dean’s Professor of Biostatistics in the Department of Public Health Sciences, School of Medicine, University of California, Davis. She enthusiastically shares her expertise as an instructor at the Radiological Society of North America's (RSNA) annual workshop in clinical trials methodology, which prepares radiologists to develop clinical research protocols and apply for funding.

Among Dr. Miglioretti’s professional memberships are the American Association for Cancer Research, the International Biometrics Society Eastern and Western North America regions, and the American Statistical Association, for which she was elected a fellow.

Research interests and experience

  • Biostatistics

    Clustered and longitudinal data analysis; latent variable modeling; assessment of diagnostic and screening tests

  • Cancer

    Biostatistics; breast cancer screening and  surveillance; mammographic breast density; risk prediction

  • Radiology

    Imaging trends; radiation exposure from medical  imaging; evaluation of imaging tests

  • Screening

 

Recent publications

Lesser RP, Webber WRS, Miglioretti DL, Pillai JJ, Agarwal S, Mori S, Morrison PF, Castagnola S, Lawal A, Lesser HJ. Cognitive effort decreases beta, alpha, and theta coherence and ends afterdischarges in human brain. Clin Neurophysiol. 2019 Jul 19. pii: S1388-2457(19)31150-2. doi: 10.1016/j.clinph.2019.07.007. [Epub ahead of print]. PubMed

Gould MK, Smith-Bindman R, Kelly K, Altman DE, Barjaktarevic I, Creekmur B, de Bie E, Dyer DS, Mortani Barbosa EJ Jr, Mularski RA, Qi L, Vaszar LT, Yu S, Miglioretti DL. Methods for the Watch the Spot Trial: a pragmatic trial of more vs. less intensive strategies for active surveillance of small pulmonary nodules. Ann Am Thorac Soc. 2019 Jul 17. doi: 10.1513/AnnalsATS.201903-268SD. [Epub ahead of print]. PubMed

Wernli KJ, Brandzel SD, Buist DM, Bush M, DeMartini W, Ichikawa L, Haas C, Henderson LM, Johnson D, Kerlikowske K, McColgin D, Miglioretti DL, Nekhlyudov L, Onega T, Rosenberg DE. Is breast MRI better at finding second breast cancers than mammograms alone for breast cancer survivors? Washington, DC: Patient-Centered Outcomes Research Institute (PCORI). 2019. https://doi.org/10.25302/5.2019.CE.13046656.

Kwan ML, Miglioretti DL, Marlow EC, Aiello Bowles EJ, Weinmann S, Cheng SY, Deosaransingh KA, Chavan P, Moy LM, Bolch WE, Duncan JR, Greenlee RT, Kushi LH, Pole JD, Rahm AK, Stout NK, Smith-Bindman R. Trends in medical imaging during pregnancy in the United States and Ontario, Canada, 1996 to 2016. JAMA Netw Open. 2019;2(7):e197249. doi: 10.1001/jamanetworkopen.2019.7249. PubMed

Kerlikowske K, Miglioretti DL, Vachon CM. Breast density information for primary care providers to facilitate discussions of dense breasts, breast cancer risk and screening choices in 2019. JAMA. 2019 Jul 2;322(1):69-70. doi: 10.1001/jama.2019.6247. PubMed

Kerlikowske K, Sprague BL, Tosteson ANA, Wernli KJ, Rauscher GH, Johnson D, Buist DSM, Onega T, Henderson LM, O'Meara ES, Miglioretti DL. Strategies to identify women at high risk of advanced breast cancer during routine screening for discussion of supplemental imaging. JAMA Intern Med. 2019 Jul 1. pii: 2737320. doi: 10.1001/jamainternmed.2019.1758. [Epub ahead of print]. PubMed

Engmann NJ, Scott C, Jensen MR, Winham SJ, Ma L, Brandt KR, Mahmoudzadeh A, Whaley DH, Hruska CB, Wu FF, Norman AD, Hiatt RA, Heine J, Shepherd J, Pankratz VS, Miglioretti DL, Kerlikowski K, Vachon CM. Longitudinal changes in volumetric breast density in healthy women across the menopausal transition. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1324-1330. Epub 2019 Jun 11. PubMed

Wernli KJ, Ichikawa K, Kerlikowske K, Buist DSM, Brandzel SD, Bush M, Johnson D, Henderson LM, Nekhlyudov L, Onega T, Sprague BL, Lee JM, Lehman C, Miglioretti DL. Surveillance breast MRI and mammography performance measures in women with a personal history of breast cancer. Radiology. 2019 Aug;292(2):311-318. doi: 10.1148/radiol.2019182475. Epub 2019 Jun 4. PubMed

Engmann NJ, Scott CG, Jensen MR, Winham S, Miglioretti DL, Ma L, Brandt K, Mahmoudzadeh A, Whaley DH, Hruska C, Wu F, Norman AD, Hiatt RA, Heine J, Shepherd J, Pankratz VS, Vachon CM, Kerlikowske K. Combined effect of volumetric breast density and body mass index on breast cancer risk. Breast Cancer Res Treat. 2019 Aug;177(1):165-173. Epub 2019 May 25. doi: 10.1007/s10549-019-05283-z. PubMed

Miglioretti DL, Abraham L, Lee CI, Buist DSM, Herschorn SD, Sprague BL, Henderson LM, Tosteson ANA, Kerlikowske K. Digital breast tomosynthesis: radiologist learning curve. Radiology. 2019;291(1):34-42. doi: 10.1148/radiol.2019182305. Epub 2019 Feb 26. PubMed

 

cancer screening

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Mailing home HPV test may offer alternative to Pap screen

Dr. Diana Buist and team reflect on HOME trial showing 50 percent screening boost in underscreened women.

birnbaum award

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HOME Trial Team wins 2019 Birnbaum Award

Interdisciplinary group shows that home-based HPV tests can boost cervical cancer screening for women at high risk.

cancer research

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Using breast MRI after cancer may lead to unneeded biopsies

A Kaiser Permanente-led BCSC study is among the largest ever to evaluate adding MRI surveillance for breast cancer survivors.

Researcher profile

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Why does Diana Miglioretti study the biostatistics of cancer screening?

Family history sparks interest for KPWHRI senior investigator, UC Davis professor, and co-leader of the BCSC.

Read it in News and Events.

KPWHRI In the Media

Mailing home HPV tests may provide alternative to Pap screening

Self-testing for cervical cancer increases screening rates

HealthDay, Nov 8, 2019