Diana L. Miglioretti, PhD

Miglioretti_Diana_L_205x293.jpg

“My research is about the risks and benefits of procedures such as cancer screening. I'm working to standardize medical imaging so patients can be confident they're getting the lowest radiation doses necessary for effective imaging.”

Diana L. Miglioretti, PhD

Senior Investigator, Kaiser Permanente Washington Health Research Institute
Dean’s Professor of Biostatistics, University of California, Davis

(530) 752-7168

Twitter: @dmiglio

Biography

Senior investigator and professor of biostatistics Diana Miglioretti, PhD, is committed to improving health care by building the evidence base for personalized cancer screening. To achieve this goal, Dr. Miglioretti pursues a rigorous combination of applied and methodological research. Her work focuses on the benefits and risks of cancer screening and appropriate use of screening and diagnostic tools including medical imaging.

Dr. Miglioretti co-leads the Breast Cancer Surveillance Consortium (BCSC)—a network of breast imaging registries that has the largest and most comprehensive collection of breast cancer screening data in the nation. Established in 1994, the BCSC is currently supported by a $17 million program project grant from the National Cancer Institute. The vast BCSC database includes information on about 12 million film, digital, and 3D mammograms for more than 2.4 million women. The BCSC also has extensive data on newer methods such as digital breast tomosynthesis (also called 3D mammography) and breast MRI (magnetic resonance imaging).

Dr. Miglioretti’s expertise in maximizing the value of the BCSC data includes establishing and evaluating data collection, helping individual sites and outside researchers with analyses, and developing new statistical techniques. In part through her efforts, results from BCSC studies have helped guide national breast cancer screening policy decisions and clinical guidelines. A few examples of Dr. Miglioretti’s BCSC studies are:

Other examples of Dr. Miglioretti’s research include:

In addition to her KPWHRI faculty position, Dr. Miglioretti is the Dean’s Professor of Biostatistics in the Department of Public Health Sciences, School of Medicine, University of California, Davis. She enthusiastically shares her expertise as an instructor at the Radiological Society of North America's (RSNA) annual workshop in clinical trials methodology, which prepares radiologists to develop clinical research protocols and apply for funding.

Among Dr. Miglioretti’s professional memberships are the American Association for Cancer Research, the International Biometrics Society Eastern and Western North America regions, and the American Statistical Association, for which she was elected a fellow.

Research interests and experience

  • Biostatistics

    Clustered and longitudinal data analysis; latent variable modeling; assessment of diagnostic and screening tests

  • Cancer

    Biostatistics; breast cancer screening and  surveillance; mammographic breast density; risk prediction

  • Radiology

    Imaging trends; radiation exposure from medical  imaging; evaluation of imaging tests

  • Screening

 

Recent publications

Kwan ML, Miglioretti DL, Marlow EC, Aiello Bowles EJ, Weinmann S, Cheng SY, Deosaransingh KA, Chavan P, Moy LM, Bolch WE, Duncan JR, Greenlee RT, Kushi LH, Pole JD, Rahm AK, Stout NK, Smith-Bindman R. Trends in medical imaging during pregnancy in the United States and Ontario, Canada, 1996 to 2016. JAMA Netw Open. 2019;2(7):e197249. doi: 10.1001/jamanetworkopen.2019.7249. PubMed

Kerlikowske K, Miglioretti DL, Vachon CM. Breast density information for primary care providers to facilitate discussions of dense breasts, breast cancer risk and screening choices in 2019. JAMA. 2019 Jul 2;322(1):69-70. doi: 10.1001/jama.2019.6247. PubMed

Kerlikowske K, Sprague BL, Tosteson ANA, Wernli KJ, Rauscher GH, Johnson D, Buist DSM, Onega T, Henderson LM, O'Meara ES, Miglioretti DL. Strategies to identify women at high risk of advanced breast cancer during routine screening for discussion of supplemental imaging. JAMA Intern Med. 2019 Jul 1. pii: 2737320. doi: 10.1001/jamainternmed.2019.1758. [Epub ahead of print]. PubMed

Engmann NJ, Scott C, Jensen MR, Winham SJ, Ma L, Brandt KR, Mahmoudzadeh A, Whaley DH, Hruska CB, Wu FF, Norman AD, Hiatt RA, Heine J, Shepherd J, Pankratz VS, Miglioretti DL, Kerlikowski K, Vachon CM. Longitudinal changes in volumetric breast density in healthy women across the menopausal transition. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1324-1330. Epub 2019 Jun 11. PubMed

Kerlikowske K, Miglioretti DL, Vachon CM. Discussions of dense breasts, breast cancer risk, and screening choices in 2019. JAMA. 2019 Jul 2;322(1):69-70. doi: 10.1001/jama.2019.6247. PubMed

Engmann NJ, Scott CG, Jensen MR, Winham S, Miglioretti DL, Ma L, Brandt K, Mahmoudzadeh A, Whaley DH, Hruska C, Wu F, Norman AD, Hiatt RA, Heine J, Shepherd J, Pankratz VS, Vachon CM, Kerlikowske K. Combined effect of volumetric breast density and body mass index on breast cancer risk. Breast Cancer Res Treat. 2019 Aug;177(1):165-173. Epub 2019 May 25. doi: 10.1007/s10549-019-05283-z. PubMed

Miglioretti DL, Abraham L, Lee CI, Buist DSM, Herschorn SD, Sprague BL, Henderson LM, Tosteson ANA, Kerlikowske K. Digital breast tomosynthesis: radiologist learning curve. Radiology. 2019;291(1):34-42. doi: 10.1148/radiol.2019182305. Epub 2019 Feb 26. PubMed

Doria-Rose VP, Greenlee RT, Buist DSM, Miglioretti DL, Corley DA, Brown JS, Clancy HA, Tuzzio L, Moy LM, Hornbrook MC, Brown ML, Ritzwoller DP, Kushi LH, Greene SM. Collaborating on data, science, and infrastructure: the 20-year journey of the Cancer Research Network. eGEMS (Wash DC). 2019;7(1):7. doi: 10.5334/egems.273. PubMed

Lee JM, Arao RF, Sprague BL, Kerlikowske K, Lehman CD, Smith RA, Henderson LM, Rauscher GH, Miglioretti DL. Performance of screening ultrasonography as an adjunct to screening mammography in women across the spectrum of breast cancer risk. JAMA Intern Med. 2019;179(5):658-67. Epub 2019/03/19. PubMed

Reed SC, Bell JF, Miglioretti DL, Nekhlyudov L, Fairman N, Joseph JG. Relationships between fear of cancer recurrence and lifestyle factors among cancer survivors. J Cancer Educ. 2019 Mar 16. pii: 10.1007/s13187-019-01509-2. doi: 10.1007/s13187-019-01509-2. [Epub ahead of print]. PubMed

 

cancer screening

Buist-HPV-Home-Test-infographic_1col.jpg

Mailing home HPV test may offer alternative to Pap screen

Dr. Diana Buist and team reflect on HOME trial showing 50 percent screening boost in underscreened women.

birnbaum award

Birnbaum-2019-Awardee-HOME_1col.jpg

HOME Trial Team wins 2019 Birnbaum Award

Interdisciplinary group shows that home-based HPV tests can boost cervical cancer screening for women at high risk.

cancer research

SusanKarenDianneMary-1col.jpg

Using breast MRI after cancer may lead to unneeded biopsies

A Kaiser Permanente-led BCSC study is among the largest ever to evaluate adding MRI surveillance for breast cancer survivors.

Researcher profile

Miglioretti-husband-dog-skiing_profile_1col.jpg

Why does Diana Miglioretti study the biostatistics of cancer screening?

Family history sparks interest for KPWHRI senior investigator, UC Davis professor, and co-leader of the BCSC.

Read it in News and Events.

women's health

miglioretti-scan-1col.jpg

Study shows benefits of 3D mammography

Digital breast tomosynthesis reduced patient recalls with no change in cancer detection, study shows.

KPWHRI In the Media

CT scan use in pregnancy rose in U.S. and Canada over two decades

Pregnant women exposed to more risky CT scans

HealthDay, Jul 24, 2019